Alanine Aminotransferase Levels and Fatty Liver in Childhood Obesity: Associations with Insulin Resistance, Adiponectin, and Visceral Fat
Burgert TS, Taksali SE, Dziura J, Goodman TR, Yeckel CW, Papademetris X, Constable RT, Weiss R, Tamborlane WV, Savoye M, Seyal AA, Caprio S. Alanine Aminotransferase Levels and Fatty Liver in Childhood Obesity: Associations with Insulin Resistance, Adiponectin, and Visceral Fat. The Journal Of Clinical Endocrinology & Metabolism 2006, 91: 4287-4294. PMID: 16912127, DOI: 10.1210/jc.2006-1010.Peer-Reviewed Original ResearchConceptsIntrahepatic fat accumulationAlanine aminotransferase levelsHepatic fat fractionVisceral fatInsulin sensitivityMagnetic resonance imagingFat accumulationAminotransferase levelsMetabolic syndromeFatty liverInsulin resistanceChildhood obesityResonance imagingLipid metabolismNonalcoholic fatty liver diseaseHispanic race/ethnicityAbdominal fat partitioningSerum aminotransferase elevationFatty liver diseaseBiomarkers of inflammationHepatic fat accumulationReduced insulin sensitivityFat fractionRace/ethnicityAminotransferase elevationEffects of hypoglycemia on human brain activation measured with fMRI
Anderson AW, Heptulla RA, Driesen N, Flanagan D, Goldberg PA, Jones TW, Rife F, Sarofin H, Tamborlane W, Sherwin R, Gore JC. Effects of hypoglycemia on human brain activation measured with fMRI. Magnetic Resonance Imaging 2006, 24: 693-697. PMID: 16824963, DOI: 10.1016/j.mri.2006.03.013.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingBrain activationHuman brain activationPassive sensory stimulationCognitive tasksFMRI activityVisual stimuliEuglycemic clamp studiesBlood glucose levelsLevel-dependent contrastEffects of hypoglycemiaBOLD signalSensory stimulationHealthy human subjectsVisual stimulationMagnetic resonance imagingHyperinsulinemic hypoglycemicHealthy brainAcute hypoglycemiaGlucose levelsClamp studiesResonance imagingFractional signal changeHypoglycemiaEuglycemia