2008
Neurogenesis and asymmetric cell division
Zhong W, Chia W. Neurogenesis and asymmetric cell division. Current Opinion In Neurobiology 2008, 18: 4-11. PMID: 18513950, DOI: 10.1016/j.conb.2008.05.002.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsAsymmetric divisionMammalian neural progenitor cellsAsymmetric cell divisionProgenitor cellsCellular diversityGlial progenyCell divisionCell biologyNeuronal lineageNeural progenitorsCentral nervous systemDivisionNeurogenesisDrosophilaVertebratesCellsLineagesNervous systemBiologyProgenyProgenitorsDiversityNeuroblastsSimilarity
2005
Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon
Backman M, Machon O, Mygland L, van den Bout CJ, Zhong W, Taketo MM, Krauss S. Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon. Developmental Biology 2005, 279: 155-168. PMID: 15708565, DOI: 10.1016/j.ydbio.2004.12.010.Peer-Reviewed Original Research
2004
Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization
Huang EJ, Li H, Tang AA, Wiggins AK, Neve RL, Zhong W, Jan LY, Jan YN. Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes & Development 2004, 19: 138-151. PMID: 15598981, PMCID: PMC540232, DOI: 10.1101/gad.1246005.Peer-Reviewed Original ResearchConceptsNuclear Notch1Sensory neuronsAxon arborizationAccumulation of Notch1Conditional mouse mutantsAxon branch pointsAfferent fibersSensory gangliaAxonal arborizationAxonal lengthSevere reductionAxon lengthArborizationCre recombinaseNotch1Endocytic-lysosomal pathwayTargeted deletionSignificant increaseUnknown mechanismNeuronsOverexpression of NumbMouse mutantsGangliaNeurogenesisPathwayContinuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis
Petersen PH, Zou K, Krauss S, Zhong W. Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis. Nature Neuroscience 2004, 7: 803-811. PMID: 15273690, DOI: 10.1038/nn1289.Peer-Reviewed Original ResearchConceptsMouse NumbProgenitor cellsEarly neurogenesisAsymmetric cell divisionProgenitor cell maintenanceLoss of NumbNeural progenitor cellsProgenitor cell depletionDrosophila melanogasterCell fateCell divisionNeuronal fateNumblNumbCortical neurogenesisStem cellsGeneral mechanismDorsal forebrainNeurogenesisCellsNervous systemFateSpecific malformationsDifferent neuronsMelanogaster
2002
Progenitor cell maintenance requires numb and numblike during mouse neurogenesis
Petersen PH, Zou K, Hwang JK, Jan YN, Zhong W. Progenitor cell maintenance requires numb and numblike during mouse neurogenesis. Nature 2002, 419: 929-934. PMID: 12410312, DOI: 10.1038/nature01124.Peer-Reviewed Original ResearchConceptsMouse NumbNeural progenitor cellsMolecular mechanismsProgenitor cellsProgenitor cell maintenanceMammalian nervous systemOnset of neurogenesisConserved homologuesMutant embryosCourse of neurogenesisCell maintenanceMouse neurogenesisNeuronal fateNumbDividing cellsNeural cellsEarly neuronsNervous systemCritical roleProgenitorsCellsNeurogenesisDrosophilaTemporal patternsEmbryogenesis
1996
Asymmetric Localization of a Mammalian Numb Homolog during Mouse Cortical Neurogenesis
Zhong W, Feder J, Jiang M, Jan L, Jan Y. Asymmetric Localization of a Mammalian Numb Homolog during Mouse Cortical Neurogenesis. Neuron 1996, 17: 43-53. PMID: 8755477, DOI: 10.1016/s0896-6273(00)80279-2.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell DivisionCell MembraneCerebral CortexDrosophilaDrosophila ProteinsEmbryo, MammalianEmbryo, NonmammalianEmbryonic and Fetal DevelopmentJuvenile HormonesMembrane ProteinsMiceMolecular Sequence DataMutationNeuronsRatsReceptors, Cell SurfaceReceptors, NotchSequence Homology, Amino AcidTissue DistributionConceptsMouse cortical neurogenesisDaughter cellsAsymmetric cell divisionCortical neurogenesisCell-cell interactionsDrosophila neurogenesisMammalian homologMutant phenotypeMouse Notch1Drosophila embryosDistinct fatesDrosophila NumbAsymmetric divisionAsymmetric localizationCell divisionDifferential segregationMolecular mechanismsNeural progenitorsNumbNeural precursorsApical membraneHomologNeurogenesisInvertebratesVertebrates