2006
The Enigma of the Numb-Notch Relationship during Mammalian Embryogenesis
Petersen PH, Tang H, Zou K, Zhong W. The Enigma of the Numb-Notch Relationship during Mammalian Embryogenesis. Developmental Neuroscience 2006, 28: 156-168. PMID: 16508312, DOI: 10.1159/000090761.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody PatterningCell DifferentiationCell DivisionCell LineageDrosophila melanogasterEmbryo, MammalianEmbryo, NonmammalianEmbryonic DevelopmentGene Expression Regulation, DevelopmentalGenes, HomeoboxMammalsMembrane ProteinsMesodermMiceMice, Mutant StrainsMutationNerve Tissue ProteinsProtein IsoformsReceptors, NotchSomitesStem CellsConceptsAsymmetric cell divisionAntagonistic rolesCell divisionCell fate specificationStem cell maintenanceDefective Notch signalingEmbryonic nervous systemStem/progenitor cellsMammalian embryogenesisNeural stem/progenitor cellsFate specificationCell fateNumb proteinCell maintenanceNumb isoformsMammalian neurogenesisMolecular basisNotch signalingDifferent fatesNumbDifferential regulationStem cellsProgenitor cellsEmbryogenesisPremature depletion
2005
Numb Proteins Specify Asymmetric Cell Fates via an Endocytosis- and Proteasome-Independent Pathway
Tang H, Rompani SB, Atkins JB, Zhou Y, Osterwalder T, Zhong W. Numb Proteins Specify Asymmetric Cell Fates via an Endocytosis- and Proteasome-Independent Pathway. Molecular And Cellular Biology 2005, 25: 2899-2909. PMID: 15798180, PMCID: PMC1069617, DOI: 10.1128/mcb.25.8.2899-2909.2005.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAmino Acid SequenceAnimalsCell DivisionDrosophila melanogasterDrosophila ProteinsEndocytosisJuvenile HormonesMembrane ProteinsMiceMolecular Sequence DataNerve Tissue ProteinsNeuropeptidesProteasome Endopeptidase ComplexProteasome InhibitorsReceptors, NotchSignal TransductionTwo-Hybrid System TechniquesVesicular Transport ProteinsConceptsNumb proteinProteasome-independent pathwayAsymmetric cell fate specificationAsymmetric cell fatesCell fate specificationEps15 homology (EH) domainE3 ubiquitin ligasesNotch protein levelsCell-cell communicationAlpha-adaptinFate specificationEndocytic proteinsDistinct binding motifsDrosophila melanogasterAsymmetric divisionCell fateHomology domainUbiquitin ligasesDaughter cellsNotch activityBinding motifEndocytosisHomologue 1Proteasome activityCell surface