Featured Publications
Mechanotransduction events at the physiological site of touch detection
Ziolkowski L, Gracheva E, Bagriantsev S. Mechanotransduction events at the physiological site of touch detection. ELife 2023, 12: e84179. PMID: 36607222, PMCID: PMC9833821, DOI: 10.7554/elife.84179.Peer-Reviewed Original ResearchLamellar cells in Pacinian and Meissner corpuscles are touch sensors
Nikolaev YA, Feketa VV, Anderson EO, Schneider ER, Gracheva EO, Bagriantsev SN. Lamellar cells in Pacinian and Meissner corpuscles are touch sensors. Science Advances 2020, 6: eabe6393. PMID: 33328243, PMCID: PMC7744075, DOI: 10.1126/sciadv.abe6393.Peer-Reviewed Original ResearchLamellar cellsR-type voltage-gated calcium channelsMeissner corpusclesAction potentialsChannel-dependent action potentialsPacinian corpusclesVoltage-gated calcium channelsSensory afferent neuronsNon-neuronal cellsBill skinAfferent neuronsNeuronal afferentsCalcium channelsElectrophysiological recordingsTactile stimuliCorpusclesIon channelsCellsSkinFirst evidenceTactile organsAfferentsNeurons3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle
Nikolaev Y, Ziolkowski L, Pang S, Li W, Feketa V, Xu C, Gracheva E, Bagriantsev S. 3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle. Science Advances 2023, 9: eadi4147. PMID: 37703368, PMCID: PMC10499330, DOI: 10.1126/sciadv.adi4147.Peer-Reviewed Original Research
2014
Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl
Schneider ER, Mastrotto M, Laursen WJ, Schulz VP, Goodman JB, Funk OH, Gallagher PG, Gracheva EO, Bagriantsev SN. Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 14941-14946. PMID: 25246547, PMCID: PMC4205607, DOI: 10.1073/pnas.1413656111.Peer-Reviewed Original ResearchConceptsTrigeminal ganglionIon channel Piezo2Light mechanical stimuliMechanoreceptive neuronsTG neuronsPrimary afferentsMechanical stimuliTrigeminal afferentsNeuronal excitationEnd organsNeuronal mechanismsDirect mechanical stimulationCellular mechanismsMechanical stimulationAfferentsNeuronsLow thresholdNumerical expansionGangliaStimuli