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Silvia Vilarinho, MD, PhD

Assistant Professor of Medicine (Digestive Diseases) and of Pathology; Associate Director, Yale MD-PhD Program, Digestive Diseases



Silvia Vilarinho is a physician-scientist who uses genetics, genomics and human samples to investigate the molecular basis of various liver diseases of unknown etiology. Using these approaches, we have identified a new mendelian form of non-cirrhotic portal hypertension, a novel bile acid disorder due to ACOX2 deficiency and a new cholestatic disorder due to mutations in KIF12. Our research goal is to discover new genes important in liver function both in health and disease and to use cell biology and animal models to determine the specific mechanism(s) linking mutant gene to disease, with potential diagnostic, therapeutic and prognostic applications.

Education & Training

  • Fellowship
    Yale University (2015)
  • Residency
    Yale University (2011)
  • Internship
    University of Minnesota (2010)
  • PhD
    University of Porto, Portugal (2008)
  • MD
    University of Porto (2004)

Honors & Recognition

Doris Duke Clinical Scientist Award2019
Junior Faculty Samuel Kushlan Award2017
AASLD Sheila Sherlock Clinical and Translational Research Award2015
Samuel Kushlan Award for Excellence in Research during Digestive Diseases Fellowship2015

Professional Service

American Association for the Study of Liver Disease (AASLD)AASLD Research Awards Committee2021 - Present
American Association for the Study of Liver Disease (AASLD)AASLD Basic Research Committee2021 - Present

Departments & Organizations