127-OR: In Vivo Genetic Evidence That the Pyruvate Kinase Isoforms PKM1 and PKM2 Differentially Control Beta-Cell Fuel Sensing
FOSTER H, HO T, POTAPENKO E, LEWANDOWSKI S, SDAO S, VANDEUSEN H, CARDONE R, KIBBEY R, MERRINS M. 127-OR: In Vivo Genetic Evidence That the Pyruvate Kinase Isoforms PKM1 and PKM2 Differentially Control Beta-Cell Fuel Sensing. Diabetes 2021, 70 DOI: 10.2337/db21-127-or.Peer-Reviewed Original ResearchInsulin secretionPK activatorΒ-cellsNational InstituteIntact β-cellsAppropriate insulin secretionGlucose intoleranceΒ-cell-specific deletionCalcium influxVivo genetic evidenceCalcium defectsHealth resourcesLow glucoseElectrophysiological evidenceIsletsMembrane depolarizationMiceServices AdministrationSecretionExcised membrane patchesSpecific deletionMitochondrial fuelsCalcium oscillationsPKM2KATP