2024
An Updated Simplified Severity Scale for Age-Related Macular Degeneration Incorporating Reticular Pseudodrusen Age-Related Eye Disease Study Report Number 42
Agrón E, Domalpally A, Chen Q, Lu Z, Chew E, Keenan T, Groups A. An Updated Simplified Severity Scale for Age-Related Macular Degeneration Incorporating Reticular Pseudodrusen Age-Related Eye Disease Study Report Number 42. Ophthalmology 2024, 131: 1164-1174. PMID: 38657840, PMCID: PMC11416341, DOI: 10.1016/j.ophtha.2024.04.011.Peer-Reviewed Original ResearchAge-Related Eye Disease StudyProgression to late AMDReticular pseudodrusenLate AMDFive-year ratesProgression rateAge-related macular degenerationSeverity ScaleEye Disease StudyClinical trial cohortIncrease prognostic accuracyPost hoc analysisMacular degenerationAREDS2Prognostic accuracyTrial cohortRisk featuresHoc analysisRisk categorizationPseudodrusenAge-relatedBaselineDisease StudyRiskExternal validation
2023
A deep network DeepOpacityNet for detection of cataracts from color fundus photographs
Elsawy A, Keenan T, Chen Q, Thavikulwat A, Bhandari S, Quek T, Goh J, Tham Y, Cheng C, Chew E, Lu Z. A deep network DeepOpacityNet for detection of cataracts from color fundus photographs. Communications Medicine 2023, 3: 184. PMID: 38104223, PMCID: PMC10725427, DOI: 10.1038/s43856-023-00410-w.Peer-Reviewed Original ResearchColor fundus photographyAnterior segment photographsSlit-lamp examinationEye Disease StudyPosterior subcapsular cataractColor fundus photographsAREDS2 participantsCataract presenceSingapore EpidemiologyDetection of cataractOphthalmology clinicFundus photographyFundus photographsSubcapsular cataractCenter gradingCataractOphthalmologistsDisease StudyBlood vesselsNuclear cataractPerson evaluationAREDS2ClinicEpidemiologyDiagnosis
2022
Predicting Age-related Macular Degeneration Progression with Longitudinal Fundus Images Using Deep Learning
Lee J, Wanyan T, Chen Q, Keenan T, Glicksberg B, Chew E, Lu Z, Wang F, Peng Y. Predicting Age-related Macular Degeneration Progression with Longitudinal Fundus Images Using Deep Learning. Lecture Notes In Computer Science 2022, 13583: 11-20. PMID: 36656604, PMCID: PMC9842432, DOI: 10.1007/978-3-031-21014-3_2.Peer-Reviewed Original ResearchLate age-related macular degenerationAge-related macular degenerationColor fundus photographsEye Disease StudyRisk prediction modelMacular degeneration progressionTriaging patientsFundus photographsPatient riskAMD cohortMacular degenerationPatient historyDegeneration progressionDisease StudyProgressionRiskSubsequent time intervalsPersonalized medicineAgeFundus imagesPatientsCohortDegenerationBaselineReticular Pseudodrusen Status, ARMS2/HTRA1 Genotype, and Geographic Atrophy Enlargement Age-Related Eye Disease Study 2 Report 32
Agrón E, Domalpally A, Cukras C, Clemons T, Chen Q, Swaroop A, Lu Z, Chew E, Keenan T, Groups A. Reticular Pseudodrusen Status, ARMS2/HTRA1 Genotype, and Geographic Atrophy Enlargement Age-Related Eye Disease Study 2 Report 32. Ophthalmology 2022, 130: 488-500. PMID: 36481221, PMCID: PMC10121754, DOI: 10.1016/j.ophtha.2022.11.026.Peer-Reviewed Original ResearchConceptsARMS2 genotypeCentral maculaAtrophy enlargementRisk allelesHTRA1 risk allelesIndependent risk factorCentral involvementEye Disease StudyFundus autofluorescence imagesGeographic atrophy areaEnlargement rateMixed model regressionAtrophy areaCommercial disclosureRisk factorsFundus photographsAnnual visitsFaster progressionGA progressionGA incidenceDisease StudySimilar findingsAutofluorescence imagesPotential mediationFaster enlargementReticular Pseudodrusen: The Third Macular Risk Feature for Progression to Late Age-Related Macular Degeneration Age-Related Eye Disease Study 2 Report 30
Agrón E, Domalpally A, Cukras C, Clemons T, Chen Q, Lu Z, Chew E, Keenan T, Groups A. Reticular Pseudodrusen: The Third Macular Risk Feature for Progression to Late Age-Related Macular Degeneration Age-Related Eye Disease Study 2 Report 30. Ophthalmology 2022, 129: 1107-1119. PMID: 35660417, PMCID: PMC9509418, DOI: 10.1016/j.ophtha.2022.05.021.Peer-Reviewed Original ResearchConceptsLate age-related macular degenerationAge-related macular degenerationAge-related eye disease studyNeovascular age-related macular degenerationColor fundus photographsHazard ratioReticular pseudodrusenGeographic atrophyHigh riskRisk factorsSeverity ScalePresence of RPDProportional hazards regression analysisMacular Degeneration AgeClinical trial cohortIndependent risk factorEye Disease StudyHazards regression analysisImportant risk factorFundus autofluorescence imagesAMD severity scaleTrial cohortRisk calculatorClinical trialsFundus photographsMulti-task deep learning-based survival analysis on the prognosis of late AMD using the longitudinal data in AREDS.
Ghahramani G, Brendel M, Lin M, Chen Q, Keenan T, Chen K, Chew E, Lu Z, Peng Y, Wang F. Multi-task deep learning-based survival analysis on the prognosis of late AMD using the longitudinal data in AREDS. AMIA Annual Symposium Proceedings 2022, 2021: 506-515. PMID: 35308963.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationImage featuresMulti-task learning frameworkConvolutional neural networkVision lossLate age-related macular degenerationEye Disease StudyLearning frameworkNeural networkFundus photographsPatient riskMacular degenerationStandard featuresSevere formComplex featuresSurvival analysisCurrent visitLongitudinal dataDisease StudyHistorical dataRapid paceFeaturesNetworkAREDSPatients
2018
DeepSeeNet: A Deep Learning Model for Automated Classification of Patient-based Age-related Macular Degeneration Severity from Color Fundus Photographs
Peng Y, Dharssi S, Chen Q, Keenan T, Agrón E, Wong W, Chew E, Lu Z. DeepSeeNet: A Deep Learning Model for Automated Classification of Patient-based Age-related Macular Degeneration Severity from Color Fundus Photographs. Ophthalmology 2018, 126: 565-575. PMID: 30471319, PMCID: PMC6435402, DOI: 10.1016/j.ophtha.2018.11.015.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overArea Under CurveDeep LearningDiagnosis, Computer-AssistedDiagnostic Techniques, OphthalmologicalDisease ProgressionFemaleGeographic AtrophyHumansMaleMiddle AgedModels, TheoreticalPhotographyProspective StudiesReproducibility of ResultsRetinal DrusenRisk FactorsSensitivity and SpecificitySeverity of Illness IndexConceptsLate age-related macular degenerationAge-related macular degenerationColor fundus photographsSeverity ScaleRetinal specialistsSeverity scoreDeep learning modelsLarge drusenFundus photographsPigmentary abnormalitiesAge-related macular degeneration (AMD) severityPatient-based scoring systemsAMD risk factorsRisk of progressionLearning modelEye Disease StudyDeep learning systemGold-standard labelsRisk factorsMacular degenerationIndividual patientsGrading processPatient-based classificationPatientsScoring system