2024
Illusory generalizability of clinical prediction models
Chekroud A, Hawrilenko M, Loho H, Bondar J, Gueorguieva R, Hasan A, Kambeitz J, Corlett P, Koutsouleris N, Krumholz H, Krystal J, Paulus M. Illusory generalizability of clinical prediction models. Science 2024, 383: 164-167. PMID: 38207039, DOI: 10.1126/science.adg8538.Peer-Reviewed Original Research
2023
Assessing the impact of a comprehensive mental health program on frontline health service workers
Ward E, Fragala M, Birse C, Hawrilenko M, Smolka C, Ambwani G, Brown M, Krystal J, Corlett P, Chekroud A. Assessing the impact of a comprehensive mental health program on frontline health service workers. PLOS ONE 2023, 18: e0294414. PMID: 37988363, PMCID: PMC10662717, DOI: 10.1371/journal.pone.0294414.Peer-Reviewed Original ResearchConceptsMental health benefitsSheehan Disability ScaleHealth service workersMental health issuesHealth benefitsHealth issuesRetrospective cohort studyPHQ-9 scaleMental health screeningComprehensive mental health programGAD-7 scaleMental health programsCare navigationCohort studyHealth screeningDisability ScaleMedication managementTreatment appointmentsFunctional impairmentLeast moderate anxietyHealth services companyOutcome assessmentHealth programsModerate anxietyAnxiety symptomsPsychedelics and the Neurobiology of Meaningfulness
Krystal J, Preller K, Corlett P, Anticevic A, Kaye A. Psychedelics and the Neurobiology of Meaningfulness. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 462-463. PMID: 37730161, DOI: 10.1016/j.bpsc.2023.09.003.Peer-Reviewed Original ResearchA pilot randomized controlled trial of ketamine in Borderline Personality Disorder
Fineberg S, Choi E, Shapiro-Thompson R, Dhaliwal K, Neustadter E, Sakheim M, Null K, Trujillo-Diaz D, Rondeau J, Pittaro G, Peters J, Corlett P, Krystal J. A pilot randomized controlled trial of ketamine in Borderline Personality Disorder. Neuropsychopharmacology 2023, 48: 991-999. PMID: 36804489, PMCID: PMC10209175, DOI: 10.1038/s41386-023-01540-4.Peer-Reviewed Original ResearchConceptsBorderline personality disorderSecondary outcome measuresOutcome measuresSocio-occupational functioningSuicidal ideationPilot studyTrial of ketaminePersonality disorderInfusion of ketaminePrimary outcome measureEffects of ketamineMidazolam groupAdverse eventsKetamine groupClinical benefitMood symptomsKetamineFDA approvalDrug midazolamInfusionBPD symptomsLarger studyDepressed moodSymptomsChronic mood
2012
NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16720-16725. PMID: 23012427, PMCID: PMC3478611, DOI: 10.1073/pnas.1208494109.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsBrainCognitionDouble-Blind MethodExcitatory Amino Acid AntagonistsFemaleHumansInfusions, IntravenousKetamineMagnetic Resonance ImagingMaleMemoryModels, NeurologicalPattern Recognition, VisualPsychomotor PerformanceReceptors, N-Methyl-D-AspartateSchizophreniaSynaptic TransmissionYoung AdultConceptsNeural systemsLarge-scale brain systemsTask-dependent activationN-methyl-D-aspartate receptorsRealistic computational modelingSevere neuropsychiatric illnessNMDA glutamate receptor antagonistGlutamate receptor antagonistsBrain systemsNMDA receptor functionTask performanceMultiple interacting regionsCognitionCortical disinhibitionGlutamatergic neurotransmissionReceptor antagonistCortical computationGlutamate's roleReciprocal relationshipNeuropsychiatric illnessLocal circuitsReceptor functionSchizophreniaPresent findingsComputational modeling
2010
Glutamatergic Model Psychoses: Prediction Error, Learning, and Inference
Corlett PR, Honey GD, Krystal JH, Fletcher PC. Glutamatergic Model Psychoses: Prediction Error, Learning, and Inference. Neuropsychopharmacology 2010, 36: 294-315. PMID: 20861831, PMCID: PMC3055519, DOI: 10.1038/npp.2010.163.Peer-Reviewed Original ResearchToward a neurobiology of delusions
Corlett PR, Taylor JR, Wang X, Fletcher PC, Krystal JH. Toward a neurobiology of delusions. Progress In Neurobiology 2010, 92: 345-369. PMID: 20558235, PMCID: PMC3676875, DOI: 10.1016/j.pneurobio.2010.06.007.Peer-Reviewed Original ResearchConceptsFundamental brain mechanismsFronto-striatal circuitsTerms of cognitionPsychological processesBrain mechanismsComputational mechanismsCortical hierarchyPrediction errorSocial learningParietal cortexExternal worldBrain circuitsNeurobiological abnormalitiesNeurobiology of delusionsBrain functionHierarchical predictionBodily agencyDelusionsMemoryReinforcement learningPerceptionMental illnessTranslational understandingLearningCognition
2009
Why Do Delusions Persist?
Corlett PR, Krystal JH, Taylor JR, Fletcher PC. Why Do Delusions Persist? Frontiers In Human Neuroscience 2009, 3: 12. PMID: 19636384, PMCID: PMC2713737, DOI: 10.3389/neuro.09.012.2009.Peer-Reviewed Original Research