2024
A model of proximate protection against pathogenic infection through shared immunity.
Nixon D, Kyza-Karavioti M, Mallick S, Daley L, Hupert N, Bachtel N, Eleftherianos I. A model of proximate protection against pathogenic infection through shared immunity. MBio 2024, e0304624. PMID: 39526781, DOI: 10.1128/mbio.03046-24.Peer-Reviewed Original ResearchDrosophila melanogaster</i>Host immune defenseTransforming biomedical researchMicrobial signalsPathogen infectionPathogen challengeAdult fliesImmunological primingInsect pathogensImmune defenseInfected hostsInnate immune primingImmune primingHostPathogensInfluence immunityBiomedical researchHealthy individualsFliesPrimed hostsProtective effectLethal doseImmunityBacteriaSpecific chemicalsAdverse Food Reactions: Physiological and Ecological Perspectives
Korn L, Kutyavin V, Bachtel N, Medzhitov R. Adverse Food Reactions: Physiological and Ecological Perspectives. Annual Review Of Nutrition 2024, 44: 155-178. PMID: 38724028, DOI: 10.1146/annurev-nutr-061021-022909.Peer-Reviewed Original Research
2023
Immune sensing of food allergens promotes avoidance behaviour
Florsheim E, Bachtel N, Cullen J, Lima B, Godazgar M, Carvalho F, Chatain C, Zimmer M, Zhang C, Gautier G, Launay P, Wang A, Dietrich M, Medzhitov R. Immune sensing of food allergens promotes avoidance behaviour. Nature 2023, 620: 643-650. PMID: 37437602, PMCID: PMC10432274, DOI: 10.1038/s41586-023-06362-4.Peer-Reviewed Original ResearchConceptsMast cellsImmune systemBALB/c miceAllergen-specific IgEDifferentiation factor 15Behavioral modificationAllergen avoidanceAllergic sensitizationAllergic inflammationFood allergyTractus solitariusC miceCysteinyl leukotrienesParabrachial nucleusAllergen ingestionE antibodiesCentral amygdalaFactor 15Mouse modelFood allergensBrain areasImmune sensingAvoidance behaviorAversive stimuliGenetic background
2019
Introduction
Bachtel N, Israni-Winger K. Introduction. Axon 2019, 93: 227-228. PMCID: PMC7309659, DOI: 10.30687/axon/2532-6848/2019/06/000.Peer-Reviewed Original ResearchThe Psychiatric Risk Gene NT5C2 Regulates Adenosine Monophosphate-Activated Protein Kinase Signaling and Protein Translation in Human Neural Progenitor Cells
Duarte RRR, Bachtel ND, Côtel MC, Lee SH, Selvackadunco S, Watson IA, Hovsepian GA, Troakes C, Breen GD, Nixon DF, Murray RM, Bray NJ, Eleftherianos I, Vernon AC, Powell TR, Srivastava DP. The Psychiatric Risk Gene NT5C2 Regulates Adenosine Monophosphate-Activated Protein Kinase Signaling and Protein Translation in Human Neural Progenitor Cells. Biological Psychiatry 2019, 86: 120-130. PMID: 31097295, PMCID: PMC6614717, DOI: 10.1016/j.biopsych.2019.03.977.Peer-Reviewed Original ResearchConceptsHuman neural progenitor cellsProtein translationNeural progenitor cellsMotility behaviorAvailable expression dataRibosomal protein S6Protein Kinase SignalingRegulation of AMPKProgenitor cellsNutrient sensing mechanismsProtein kinase alphaQuantitative polymerase chain reactionPsychiatric risk allelesDrosophila melanogasterTranscriptional changesKinase signalingProtein S6Transcriptomic profilingRNA interferenceNeural stem cellsExpression changesKinase alphaUnknown roleExpression dataHuman dorsolateral prefrontal cortex22THE PSYCHIATRIC RISK GENE NT5C2 REGULATES PROTEIN TRANSLATION IN HUMAN NEURAL PROGENITOR CELLS, AND IS INVOLVED IN LOCOMOTOR BEHAVIOUR IN DROSOPHILA MELANOGASTER
Duarte R, Bachtel N, Eleftherianos I, Nixon D, Murray R, Bray N, Powell T, Srivastava D. 22THE PSYCHIATRIC RISK GENE NT5C2 REGULATES PROTEIN TRANSLATION IN HUMAN NEURAL PROGENITOR CELLS, AND IS INVOLVED IN LOCOMOTOR BEHAVIOUR IN DROSOPHILA MELANOGASTER. European Neuropsychopharmacology 2019, 29: s1078. DOI: 10.1016/j.euroneuro.2018.08.029.Peer-Reviewed Original Research
2018
Short Communication: Expression of Host Restriction Factors by Memory CD4+ T Cells Differs Between Healthy Donors and HIV-1-Infected Individuals with Effective Antiretroviral Therapy
Bachtel ND, Beckerle GA, Mota TM, de Mulder Rougvie M, Raposo RAS, Jones RB, Nixon DF, Apps R. Short Communication: Expression of Host Restriction Factors by Memory CD4+ T Cells Differs Between Healthy Donors and HIV-1-Infected Individuals with Effective Antiretroviral Therapy. AIDS Research And Human Retroviruses 2018, 35: 108-111. PMID: 30198299, PMCID: PMC6343196, DOI: 10.1089/aid.2018.0162.Peer-Reviewed Original ResearchConceptsHIV-1-infected individualsHost restriction factorsRestriction factor expressionEffective antiretroviral therapyAntiretroviral therapyUninfected individualsMemory CD4Viral reservoirRestriction factorsT cellsChronic HIV-1 infectionHIV-1 gag DNAHIV-1 reservoir sizeFactor expressionMemory T cell compartmentQuantitative viral outgrowth assaysART-suppressed individualsSuppressive antiretroviral therapyViral outgrowth assaysHIV-1 infectionT cell compartmentDroplet digital polymerase chain reactionGag DNAViral loadImmune activationPublisher Correction: Evidence that CD32a does not mark the HIV-1 latent reservoir
Osuna C, Lim S, Kublin J, Apps R, Chen E, Mota T, Huang S, Ren Y, Bachtel N, Tsibris A, Ackerman M, Jones R, Nixon D, Whitney J. Publisher Correction: Evidence that CD32a does not mark the HIV-1 latent reservoir. Nature 2018, 563: e33-e33. PMID: 30315222, DOI: 10.1038/s41586-018-0611-3.Peer-Reviewed Original ResearchOR21 HLA-C downregulation by HIV adapts to host HLA genotype
Apps R, Bachtel N, Umviligihozo G, Pickering S, Mota T, Liang H, Del Prete G, Chatterjee P, Lee G, Thomas R, Brockman M, Neil S, Carrington M, Bwana B, Bangsberg D, Martin J, Kallas E, Donini C, Cerqueira N, O’Doherty U, Hahn B, Jones B, Brumme Z, Nixon D. OR21 HLA-C downregulation by HIV adapts to host HLA genotype. Human Immunology 2018, 79: 28. DOI: 10.1016/j.humimm.2018.07.026.Peer-Reviewed Original ResearchDownregulation of HLAViral downregulationHLA genotypeChronic infectionPrimary HIV-1 virusesEffective anti-retroviral therapySpecific CTL responseAnti-retroviral therapyTreatment-naïve individualsViral immune evasionHLA-C allelesHIV-1 virusCTL responsesAcute infectionHIV infectionHLA moleculesViral protein VpuUntreated individualsImmune evasionHLAHIV virusViral modulationViral isolatesHIVInfectionEvidence that CD32a does not mark the HIV-1 latent reservoir
Osuna CE, Lim SY, Kublin JL, Apps R, Chen E, Mota TM, Huang SH, Ren Y, Bachtel ND, Tsibris AM, Ackerman ME, Jones RB, Nixon DF, Whitney JB. Evidence that CD32a does not mark the HIV-1 latent reservoir. Nature 2018, 561: e20-e28. PMID: 30232424, PMCID: PMC6528470, DOI: 10.1038/s41586-018-0495-2.Peer-Reviewed Original ResearchHLA-C downregulation by HIV-1 adapts to host HLA genotype
Bachtel ND, Umviligihozo G, Pickering S, Mota T, Liang H, Del Prete GQ, Chatterjee P, Lee GQ, Thomas R, Brockman MA, Neil S, Carrington M, Bwana B, Bangsberg DR, Martin JN, Kallas EG, Donini C, Cerqueira NB, O’Doherty U, Hahn BH, Jones RB, Brumme ZL, Nixon DF, Apps R. HLA-C downregulation by HIV-1 adapts to host HLA genotype. PLOS Pathogens 2018, 14: e1007257. PMID: 30180214, PMCID: PMC6138419, DOI: 10.1371/journal.ppat.1007257.Peer-Reviewed Original ResearchConceptsViral downregulationHLA-C allelesHLA-C expressionChronic infectionHLA genotypeHIV-1Primary HIV-1 variantsPrimary HIV-1 virusesEffective anti-retroviral therapyAnti-retroviral therapyTreatment-naïve individualsDownregulation of HLAMonths of infectionHIV-1 variantsViral immune evasionHIV-1 virusSurface HLACTL responsesUntreated infectionViral protein VpuImmune evasionHLAInfectionInfected cellsDownregulationAllatostatin C modulates nociception and immunity in Drosophila
Bachtel ND, Hovsepian GA, Nixon DF, Eleftherianos I. Allatostatin C modulates nociception and immunity in Drosophila. Scientific Reports 2018, 8: 7501. PMID: 29760446, PMCID: PMC5951828, DOI: 10.1038/s41598-018-25855-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntimicrobial Cationic PeptidesBacterial InfectionsBlood ProteinsDisease Models, AnimalDrosophila melanogasterDrosophila ProteinsFemaleGene Knockdown TechniquesHot TemperatureHyperalgesiaImmunityIon ChannelsMutationNeuropeptidesNociceptionPhotorhabdusReceptors, G-Protein-CoupledUp-RegulationConceptsReceptor 2Bacterial infectionsHost survivalAbsence of infectionLigand-gated ion channelsInflammatory painNociceptive neuronsChronic inflammationImmune infiltrationInflammatory responseAlters immunityImmunosuppressive substancesThermal nociceptionPathogenic bacterial infectionsNeuronal roleNociceptionRobust upregulationAllatostatin receptorImmune deficiency (IMD) pathwayBacterial challengeInfectionMicrobial stimulationImmune signalingHomeostatic conditionsDirect activationP-A3 Limitations of CD32a expression as a marker of the HIV latent reservoir
Apps R, Bachtel N, Huang J, Ren Y, Tovanbutra S, Phanuphak N, Kroon E, Ananworanich J. P-A3 Limitations of CD32a expression as a marker of the HIV latent reservoir. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2018, 77: 53. DOI: 10.1097/01.qai.0000532646.39289.6e.Peer-Reviewed Original ResearchReplication-competent HIVT cellsPeripheral bloodDirect markerHIV disease progressionT cell populationsCell-associated DNAHIV latent reservoirOriginal reportCD32a expressionLatent reservoirCD32 expressionDisease progressionHIV provirusCD4Flow cytometryLatent cellsCD32BloodInducible virusLack of correlationCell populationsExpression levelsHIVIgG binding
2017
OP1.5 CD32 does not mark the HIV-1/SIV latent reservoir
Osuna C, Apps R, Lim S, Kublin J, Thomas R, Chen E, Yoon G, Huang S, Chan D, Truong R, Ren Y, Bachtel N, Ackerman M, Ananworanich J, Barouch D, Michael N, Jones R, Nixon D, Whitney J, Collaboratory T. OP1.5 CD32 does not mark the HIV-1/SIV latent reservoir. Journal Of Virus Eradication 2017, 3: 2. DOI: 10.1016/s2055-6640(20)30524-0.Peer-Reviewed Original Research