A Mouse Model of MHV‐1 Virus Infection for Study of Acute and Long COVID Infection
Masciarella A, Di Gregorio D, Ramamoorthy R, Hussain H, Jayakumar A, Paidas M. A Mouse Model of MHV‐1 Virus Infection for Study of Acute and Long COVID Infection. Current Protocols 2023, 3: e896. PMID: 37867460, PMCID: PMC10606938, DOI: 10.1002/cpz1.896.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Pathological changesMouse modelTransgenic miceLong-term organ dysfunctionSARS-CoV-2 pathophysiologyIrreversible neurological complicationsPotential therapeutic interventionsAvailable human dataBiosafety level 2 laboratoryNon-human primatesBiosafety level 3 laboratoryNeurological complicationsOrgan dysfunctionAcute stageClinical symptomsLong-term effectsSevere casesClinical observationsViral infectionTherapeutic interventionsMHV-1Animal preparationsWeight lossBSL-3 laboratoryMaternal SARS-CoV-2, Placental Changes and Brain Injury in 2 Neonates
Benny M, Bandstra E, Saad A, Lopez-Alberola R, Saigal G, Paidas M, Jayakumar A, Duara S. Maternal SARS-CoV-2, Placental Changes and Brain Injury in 2 Neonates. Pediatrics 2023, 151: e2022058271. PMID: 37021494, PMCID: PMC10467358, DOI: 10.1542/peds.2022-058271.Peer-Reviewed Original ResearchConceptsSARS-CoV-2SARS-CoV-2 infectionBrain injuryFetal brainSevere acute respiratory syndrome coronavirus disease 2Detectable SARS-CoV-2 antibodiesMaternal SARS-CoV-2 infectionSARS-CoV-2-positive mothersLong-term neurodevelopmental sequelaeMaternal SARS-CoV-2SARS-CoV-2 antibodiesStromal cell-derived factor-1Sudden unexpected infant deathInfant brainCell-derived factor-1Fetal vascular malperfusionSevere parenchymal atrophyHypoxic-ischemic encephalopathyBlood inflammatory markersUnexpected infant deathEarly-onset seizuresHuman chorionic gonadotropinOxidative stress injuryMonths of ageSARS-CoV-2 nucleocapsid protein