2024
Mesenchymal Stromal Cell Therapy Alleviates Ovalbumin-Induced Chronic Airway Remodeling by Suppressing M2 Macrophage Polarization
Yu H, Zhu G, Qin Q, Wang X, Guo X, Gu W. Mesenchymal Stromal Cell Therapy Alleviates Ovalbumin-Induced Chronic Airway Remodeling by Suppressing M2 Macrophage Polarization. Inflammation 2024, 47: 1298-1312. PMID: 38316671, DOI: 10.1007/s10753-024-01977-9.Peer-Reviewed Original ResearchSuppressed macrophage M2 polarizationEffect of mesenchymal stromal/stem cellsMesenchymal stromal/stem cellsChronic airway remodelingAirway remodelingChronic asthmaTherapeutic effects of mesenchymal stromal/stem cellsMacrophage M2 polarizationMouse modelModel of chronic asthmaMouse model of chronic asthmaTh2 cytokine levelsTransforming growth factor-bM2 polarizationMechanisms of airway remodelingInflammatory cell infiltrationInhibition of ER stressSuppressing M2 macrophage polarizationER stressGrowth factor BOxidative stressPhenotype of macrophagesAnti-inflammatory effectsM2 macrophage polarizationAirway hyperresponsiveness
2020
p62-dependent autophagy in airway smooth muscle cells regulates metabolic reprogramming and promotes airway remodeling
Yu H, Cheng Y, Zhang G, Wang X, Gu W, Guo X. p62-dependent autophagy in airway smooth muscle cells regulates metabolic reprogramming and promotes airway remodeling. Life Sciences 2020, 266: 118884. PMID: 33310038, DOI: 10.1016/j.lfs.2020.118884.Peer-Reviewed Original ResearchConceptsKnockdown of p62Mechanism of p62Bronchial smooth muscle cellsP62-dependent autophagyIncreased p62 expressionP62 expressionAirway remodelingGlucose consumptionAutophagy fluxAutophagic fluxCCK8 assayP62 overexpressionTranswell methodP62Glycolytic genesGlycolytic proteinsLactate productionMetabolic reprogrammingMigration in vitroHuman bronchial smooth muscle cellsBSMC proliferationCell migrationSmooth muscle cellsAirway remodeling processPromote airway remodeling