2018
Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial
Barcelos NM, Van Ness PH, Wagner AF, MacAvoy MG, Mecca AP, Anderson GM, Trentalange M, Hawkins KA, Sano M, Arnsten AFT, van Dyck CH. Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial. Neurobiology Of Aging 2018, 70: 117-124. PMID: 30007160, PMCID: PMC6503670, DOI: 10.1016/j.neurobiolaging.2018.05.033.Peer-Reviewed Original ResearchConceptsDose of guanfacineQuality of lifeZ-scoreCognitive functionPrefrontal cognitive dysfunctionCommon adverse eventsPrimary outcome measureRandomized clinical trialsGlobal functionOlder participantsHealthy older participantsPrefrontal cognitive functionDry mouthAdverse eventsAgonist guanfacineClinical trialsGuanfacine treatmentCognitive dysfunctionMean changeOutcome measuresPlaceboGuanfacineOlder individualsWeeksDose
2004
Who Can Stay at Home?: Assessing the Capacity to Choose to Live in the Community
Cooney LM, Kennedy GJ, Hawkins KA, Hurme SB. Who Can Stay at Home?: Assessing the Capacity to Choose to Live in the Community. JAMA Internal Medicine 2004, 164: 357-360. PMID: 14980985, DOI: 10.1001/archinte.164.4.357.Peer-Reviewed Original ResearchConceptsExecutive functionUnsafe actionsDecision-making abilityProblem-solving abilityCognitive functionImpaired insightPerson's capacityChoices of individualsIndependent livingOlder individualsSocial agencyDeficitsIndividualsAbilityPlanning limitsDecisionsMedical decisionsImplicationsActionFinal responsibilityGlobal testChoiceResponsibility