Featured Publications
Vaccination With Leptospira interrogans PF07598 Gene Family-Encoded Virulence Modifying Proteins Protects Mice From Severe Leptospirosis and Reduces Bacterial Load in the Liver and Kidney
Chaurasia R, Salovey A, Guo X, Desir G, Vinetz JM. Vaccination With Leptospira interrogans PF07598 Gene Family-Encoded Virulence Modifying Proteins Protects Mice From Severe Leptospirosis and Reduces Bacterial Load in the Liver and Kidney. Frontiers In Cellular And Infection Microbiology 2022, 12: 926994. PMID: 35837473, PMCID: PMC9274288, DOI: 10.3389/fcimb.2022.926994.Peer-Reviewed Original ResearchConceptsLethal challenge infectionChallenge infectionBacterial loadC3H/HeJ miceKey target organClinical pathogenesisSevere leptospirosisOrgan infectionProtein immunizationHeJ miceSerovar CanicolaTarget organsAnimal modelsLeptospirosis pathogenesisCellular pathogenesisMicePathogenesisInfectionLeptospira interrogansVirulence factorsModifying proteinsImmunizationKidneyLeptospirosisLiver
2018
Experimental Infection of Rattus norvegicus by the Group II Intermediate Pathogen, Leptospira licerasiae.
Fernandez C, Lubar AA, Vinetz JM, Matthias MA. Experimental Infection of Rattus norvegicus by the Group II Intermediate Pathogen, Leptospira licerasiae. American Journal Of Tropical Medicine And Hygiene 2018, 99: 275-280. PMID: 29943708, PMCID: PMC6090328, DOI: 10.4269/ajtmh.17-0844.Peer-Reviewed Original ResearchConceptsOral routeHuman seroreactivitySprague-Dawley ratsRoute of infectionExperimental infection modelQuantitative polymerase chain reactionTranscutaneous routeGastric gavageParenteral inoculationClinical historyPolymerase chain reactionRenal colonizationGroup IIKidney tissuePeruvian Amazon cityExperimental infectionInfectionInfection modelChain reactionSeroreactivityHigh rateRatsReservoir hostsAmazon cityGavage