Featured Publications
Demographic, exposure, clinical, biochemical and diagnostic data of febrile patients recruited for the largest field study on leptospirosis in Sri Lanka
Agampodi S, Warnasekara J, Siribaddana S, Kularatna S, Gamage C, Jayasundara D, Senevirathna I, Srimantha S, Kappagoda C, Weerawansa P, Pilapitiya S, Lokunarangoda N, Sarathchandra C, Senanayake H, Matthias M, Vinetz J. Demographic, exposure, clinical, biochemical and diagnostic data of febrile patients recruited for the largest field study on leptospirosis in Sri Lanka. Data In Brief 2022, 43: 108378. PMID: 35770027, PMCID: PMC9234077, DOI: 10.1016/j.dib.2022.108378.Peer-Reviewed Original Research
2023
Optimization of Plasmodium vivax infection of colonized Amazonian Anopheles darlingi
Andrade A, Santos N, Bastos A, Pontual J, Araújo C, Lima A, Martinez L, Ferreira A, Aguiar A, Teles C, Guido R, Santana R, Lopes S, Medeiros J, Rizopoulos Z, Vinetz J, Campo B, Lacerda M, Araújo M. Optimization of Plasmodium vivax infection of colonized Amazonian Anopheles darlingi. Scientific Reports 2023, 13: 18207. PMID: 37875508, PMCID: PMC10598059, DOI: 10.1038/s41598-023-44556-y.Peer-Reviewed Original ResearchConceptsP. vivax liver stagesPlasmodium vivax infectionPlasmodium vivax sporozoitesLiver stage parasitesP. vivax sporozoitesFemale anopheline mosquitoesVivax infectionLiver stagesHepatocyte infectionVaccine developmentStage parasitesSporozoite viabilityMembrane feeding systemSporozoite productionDrug developmentSporozoitesAnopheline mosquitoesInfectionParasite biologyArtificial membrane feeding systemPatientsSimple centrifugation methodSerum replacementBloodTransmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi
Andrade A, Santos N, Bastos A, Pontual J, Araújo J, Silva A, Martinez L, Lima A, Aguiar A, Teles C, Medeiros J, Pereira D, Vinetz J, Gazzinelli R, Araújo M. Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi. PLOS Neglected Tropical Diseases 2023, 17: e0011425. PMID: 37327209, PMCID: PMC10310017, DOI: 10.1371/journal.pntd.0011425.Peer-Reviewed Original ResearchConceptsDensity of gametocytesTransmission-blocking efficacyPlasmodium vivax malariaTransmission-blocking activityImportant infectious diseasesOne-doseVivax malariaP. vivaxMosquito infectionPlasmodium vivaxTreatment groupsPatient's bloodGametocyte productionMalaria transmissionInfectious diseasesGenus PlasmodiumMalariaTreatmentChloroquinePrimaquineVivaxBloodDirect membraneBiological characteristicsMosquitoes
2021
Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi
Almeida GG, Costa PAC, da Silva Araujo M, Gomes GR, Carvalho AF, Figueiredo MM, Pereira DB, Tada MS, Medeiros JF, da Silva Soares I, Carvalho LH, Kano FS, de Castro M, Vinetz JM, Golenbock DT, do Valle Antonelli L, Gazzinelli RT. Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi. PLOS Neglected Tropical Diseases 2021, 15: e0009077. PMID: 34714821, PMCID: PMC8555776, DOI: 10.1371/journal.pntd.0009077.Peer-Reviewed Original ResearchConceptsAsymptomatic individualsP. vivaxP. vivax malaria patientsP. vivax infectionVivax malaria patientsPlasmodium vivax malariaLow endemicity areaMalaria patientsSymptomatic patientsAsymptomatic infectionVivax malariaVivax infectionInfectious reservoirLow parasitemiaUninfected controlsEndemic regionsMalaria transmissionInfectivity ratesMalaria parasitesBiochemical parametersParasitemiaBloodPotential rolePatientsInfection
2018
Continuous Supply of Plasmodium vivax Sporozoites from Colonized Anopheles darlingi in the Peruvian Amazon
Moreno M, Tong-Rios C, Orjuela-Sanchez P, Carrasco-Escobar G, Campo B, Gamboa D, Winzeler EA, Vinetz JM. Continuous Supply of Plasmodium vivax Sporozoites from Colonized Anopheles darlingi in the Peruvian Amazon. ACS Infectious Diseases 2018, 4: 541-548. PMID: 29465219, PMCID: PMC5902790, DOI: 10.1021/acsinfecdis.7b00195.Peer-Reviewed Original ResearchConceptsPlasmodium vivax sporozoitesDonor seraPlasmodium vivax liver stagesStandard membrane feeding assaysMalaria-endemic settingsMembrane feeding assaysSporozoite productionInfectious blood mealInfected subjectsNaïve serumBlood-fed mosquitoesLiver stagesDonor bloodBlood samplesVaccine developmentMosquito midgutSerumBlood mealBloodMosquito survivalSporozoitesMosquitoesAnophelesAnticoagulantsInfection