2020
Connectomic analysis reveals an interneuron with an integral role in the retinal circuit for night vision
Park SJ, Lieberman EE, Ke JB, Rho N, Ghorbani P, Rahmani P, Jun NY, Lee HL, Kim IJ, Briggman KL, Demb JB, Singer JH. Connectomic analysis reveals an interneuron with an integral role in the retinal circuit for night vision. ELife 2020, 9: e56077. PMID: 32412412, PMCID: PMC7228767, DOI: 10.7554/elife.56077.Peer-Reviewed Original ResearchConceptsAII amacrine cellsProjection neuronsSingle interneuron typeConnectomic analysisBipolar cell pathwaysNovel neural circuitGABAergic cellsAmacrine cellsCentral neuronsGanglion cellsSynaptic layersRetinal circuitsInterneuron typesSurround inhibitionMouse retinaNight visionON responseExcitatory centerOptogenetic analysesNeural circuitsInhibitory surroundCell pathwaysRod photoreceptorsReceptive fieldsRb pathway
2016
Divisive suppression explains high-precision firing and contrast adaptation in retinal ganglion cells
Cui Y, Wang YV, Park SJ, Demb JB, Butts DA. Divisive suppression explains high-precision firing and contrast adaptation in retinal ganglion cells. ELife 2016, 5: e19460. PMID: 27841746, PMCID: PMC5108594, DOI: 10.7554/elife.19460.Peer-Reviewed Original ResearchConceptsExcitatory synaptic inputsSynaptic inputsGanglion cell functionContrast adaptationRetinal ganglion cellsGanglion cell inputsComplex neural circuitsGanglion cell outputCell-intrinsic mechanismsGanglion cellsDivisive interactionMouse retinaNeural circuitsSpike responsesCell functionDivisive suppressionSensory processingCell inputSpike generation mechanismMillisecond precisionVisual processingSpike trainsCell outputSuppressionRetinaParallel Computations in Insect and Mammalian Visual Motion Processing
Clark DA, Demb JB. Parallel Computations in Insect and Mammalian Visual Motion Processing. Current Biology 2016, 26: r1062-r1072. PMID: 27780048, PMCID: PMC5108051, DOI: 10.1016/j.cub.2016.08.003.Peer-Reviewed Original ResearchComplexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses
Mortensen LS, Park SJ, Ke JB, Cooper BH, Zhang L, Imig C, Löwel S, Reim K, Brose N, Demb JB, Rhee JS, Singer JH. Complexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses. Cell Reports 2016, 15: 2239-2250. PMID: 27239031, PMCID: PMC5134263, DOI: 10.1016/j.celrep.2016.05.012.Peer-Reviewed Original ResearchConceptsRod bipolarsAsynchronous releaseAmacrine cell synapsesRetinal ganglion cellsRetinal pathwaysGanglion cellsCell synapsesRetinal circuitsRibbon synapsesMouse retinaMultivesicular releaseNeural circuitsComplexin proteinsSynapsesCircuit functionCplx3SignalingStudy linksReleaseExocytosisRB outputRetina
2013
Transsynaptic Tracing with Vesicular Stomatitis Virus Reveals Novel Retinal Circuitry
Beier KT, Borghuis BG, El-Danaf RN, Huberman AD, Demb JB, Cepko CL. Transsynaptic Tracing with Vesicular Stomatitis Virus Reveals Novel Retinal Circuitry. Journal Of Neuroscience 2013, 33: 35-51. PMID: 23283320, PMCID: PMC3711516, DOI: 10.1523/jneurosci.0245-12.2013.Peer-Reviewed Original ResearchConceptsStarburst amacrine cellsVesicular stomatitis virusDirection-selective retinal ganglion cellsRetinal ganglion cell typesGanglion cell typesRetinal ganglion cellsStomatitis virusCell typesDensity of neuropilTranssynaptic tracerNeurotropic virusesPresynaptic sourceAmacrine cellsSynaptic relationshipsGanglion cellsRetinal circuitryPostsynaptic neuronsSynaptic partnersMouse retinaViral tracersCell type-specific dissectionNeural circuitsNeural circuitryViral spreadVirus
2011
A Synaptic Mechanism for Retinal Adaptation to Luminance and Contrast
Jarsky T, Cembrowski M, Logan SM, Kath WL, Riecke H, Demb JB, Singer JH. A Synaptic Mechanism for Retinal Adaptation to Luminance and Contrast. Journal Of Neuroscience 2011, 31: 11003-11015. PMID: 21795549, PMCID: PMC3152984, DOI: 10.1523/jneurosci.2631-11.2011.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAmacrine CellsAnimalsBiophysical PhenomenaBiophysicsCalciumContrast SensitivityElectric StimulationExcitatory Postsynaptic PotentialsFemaleIn Vitro TechniquesLightingMaleMiceMice, Inbred C57BLModels, NeurologicalNumerical Analysis, Computer-AssistedPatch-Clamp TechniquesPhotic StimulationPresynaptic TerminalsRetinaRetinal Bipolar CellsSynaptic TransmissionConceptsSynaptic mechanismsSynaptic transmissionBipolar cell synaptic transmissionMouse retinal slice preparationVesicle depletionCommon synaptic mechanismsPrimary sensory circuitsUse-dependent regulationAII amacrine cellsContrast adaptationRetinal slice preparationBipolar cell synapsesCell synaptic transmissionRetinal neural circuitWhole-cell recordingsRetinal bipolar cellsPhasic transmissionTonic transmissionAmacrine cellsSlice preparationCell synapsesBipolar cellsSame cellular mechanismsSensory circuitsNeural circuits
2009
Activity acts locally
Demb JB, Feller MB. Activity acts locally. Nature 2009, 460: 961-963. PMID: 19693075, DOI: 10.1038/460961a.Peer-Reviewed Original Research
2002
Connexin36 Forms Synapses Essential for Night Vision
Demb JB, Pugh EN. Connexin36 Forms Synapses Essential for Night Vision. Neuron 2002, 36: 551-553. PMID: 12441044, DOI: 10.1016/s0896-6273(02)01062-0.Commentaries, Editorials and Letters