2024
Function and evolution of Ir52 receptors in mate detection in Drosophila
Luo Y, Talross G, Carlson J. Function and evolution of Ir52 receptors in mate detection in Drosophila. Current Biology 2024 PMID: 39471807, DOI: 10.1016/j.cub.2024.10.001.Peer-Reviewed Original ResearchMating partnersCluster of genesPotential mating partnersSexually dimorphic neuronsCourtship behaviorEvolutionary timeMate detectionExpression systemFly legFruit flyFly speciesSpeciesBiological problemsTaste neuronsMatingPheromone extractsFliesReceptorsDrosophilaCourtshipGenesNeuronsPheromoneCircuit mappingExpression
2023
The rich non-coding RNA landscape of the Drosophila antenna
Talross G, Carlson J. The rich non-coding RNA landscape of the Drosophila antenna. Cell Reports 2023, 42: 112482. PMID: 37167060, PMCID: PMC10431215, DOI: 10.1016/j.celrep.2023.112482.Peer-Reviewed Original ResearchConceptsDrosophila antennaPheromone-sensing neuronsLong non-coding RNAsNon-coding RNAsDrosophila olfactory systemRole of lncRNAsMultiple complex behaviorsRNA landscapeOlfactory receptor neuronsNeuronal lncRNAsNeural developmentLncRNAsReceptor neuronsModel systemPheromonal responsesOlfactory systemCritical roleNeuron mapNervous systemRNACombination of lncRNAsSpeciationNeuronsRole
2022
Meeting a threat of the Anthropocene: Taste avoidance of metal ions by Drosophila
Xiao S, Baik LS, Shang X, Carlson JR. Meeting a threat of the Anthropocene: Taste avoidance of metal ions by Drosophila. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2204238119. PMID: 35700364, PMCID: PMC9231609, DOI: 10.1073/pnas.2204238119.Peer-Reviewed Original ResearchConceptsGenerations of exposureDipteran speciesAnthropogenic stressorsGR familyEnvironmental changesToxic chemical compoundsBitter-sensing neuronsTaste organsTaste receptorsAvoidance of feedingSugar-sensing neuronsElevated concentrationsZinc ionsDrosophilaChemical compoundsInsectsHuman activitiesBehavioral responsesReceptorsOrganismsFliesSpeciesNeuronsRapid rateDifferent subsetsIr56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila
Dweck HKM, Talross GJS, Luo Y, Ebrahim SAM, Carlson JR. Ir56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila. Current Biology 2022, 32: 1776-1787.e4. PMID: 35294865, PMCID: PMC9050924, DOI: 10.1016/j.cub.2022.02.063.Peer-Reviewed Original ResearchConceptsSalt tasteBitter-sensing neuronsStop codonLoss of functionNumber of speciesIonotropic receptorsIonotropic receptor familyN-terminal regionReceptor familyNeuronsDrosophila speciesPremature stop codonTaste modalitiesAncient functionGR familySalt responseSense codonsMolecular basisAtypical memberSalt detectionModalitiesCodonSensory modalitiesDrosophilaBehavioral responses
2017
A receptor and neuron that activate a circuit limiting sucrose consumption
Joseph RM, Sun JS, Tam E, Carlson JR. A receptor and neuron that activate a circuit limiting sucrose consumption. ELife 2017, 6: e24992. PMID: 28332980, PMCID: PMC5388533, DOI: 10.7554/elife.24992.Peer-Reviewed Original Research
2014
The Drosophila IR20a Clade of Ionotropic Receptors Are Candidate Taste and Pheromone Receptors
Koh TW, He Z, Gorur-Shandilya S, Menuz K, Larter NK, Stewart S, Carlson JR. The Drosophila IR20a Clade of Ionotropic Receptors Are Candidate Taste and Pheromone Receptors. Neuron 2014, 83: 850-865. PMID: 25123314, PMCID: PMC4141888, DOI: 10.1016/j.neuron.2014.07.012.Peer-Reviewed Original ResearchConceptsPheromone receptorsIonotropic receptorsGustatory receptor genesMale mating behaviorAdaptive evolutionTaste neuronsMale forelegsDimorphic expressionConspecific femalesCladeMating behaviorReceptor geneGenesTaste organsFliesNeural circuitsTaste receptorsNeuronsReceptorsSexual behaviorExpressionDrosophilaInsectsComprehensive analysisCourtship
2012
Non-synaptic inhibition between grouped neurons in an olfactory circuit
Su CY, Menuz K, Reisert J, Carlson JR. Non-synaptic inhibition between grouped neurons in an olfactory circuit. Nature 2012, 492: 66-71. PMID: 23172146, PMCID: PMC3518700, DOI: 10.1038/nature11712.Peer-Reviewed Original ResearchConceptsOlfactory receptor neuronsDrosophila olfactory receptor neuronsMalaria mosquito AnophelesMosquito AnophelesMammalian taste budsSustained responseInsect controlLateral inhibitionBroad occurrenceChemosensory sensillaOlfactory behaviorTransient activationSensory organsMarked compartmentalizationOlfactory circuitFunctional impactReceptor neuronsReceptor cellsOlfactory informationInhibitionInsectsTaste budsNeuronsCompartmentalizationBuds
2007
Two Gr Genes Underlie Sugar Reception in Drosophila
Dahanukar A, Lei YT, Kwon JY, Carlson JR. Two Gr Genes Underlie Sugar Reception in Drosophila. Neuron 2007, 56: 503-516. PMID: 17988633, PMCID: PMC2096712, DOI: 10.1016/j.neuron.2007.10.024.Peer-Reviewed Original ResearchConceptsSubset of sugarsReporter gene expressionSugar-sensing neuronsDouble mutantSugar receptionMolecular basisGenetic analysisGene expressionGr5aDrosophilaReceptor geneSitu hybridizationGenesNeuronsGr64aPrimary receptorTaste receptorsDistinct projectionsReceptorsTemporal dynamicsSugarsMutantsBehavioral responsesLabellumReporter
2005
Coexpression of Two Functional Odor Receptors in One Neuron
Goldman AL, van Naters W, Lessing D, Warr CG, Carlson JR. Coexpression of Two Functional Odor Receptors in One Neuron. Neuron 2005, 45: 661-666. PMID: 15748842, DOI: 10.1016/j.neuron.2005.01.025.Peer-Reviewed Original Research
2004
The Molecular Basis of Odor Coding in the Drosophila Antenna
Hallem EA, Ho MG, Carlson JR. The Molecular Basis of Odor Coding in the Drosophila Antenna. Cell 2004, 117: 965-979. PMID: 15210116, DOI: 10.1016/j.cell.2004.05.012.Peer-Reviewed Original ResearchConceptsOlfactory receptor neuronsDrosophila antennaMolecular basisOdorant receptor repertoireFunctional analysisReceptor repertoireOlfactory organOdor codingReceptor neuronsIndividual receptorsSame cellsReceptor transductionNumber of receptorsNeuron mapReceptorsRepertoireBreadth of tuningTransductionDifferent odorantsInhibitory responsesOdorantsElectrophysiological recordingsNeuronsCellsVivo
2003
Drosophila Gr5a encodes a taste receptor tuned to trehalose
Chyb S, Dahanukar A, Wickens A, Carlson JR. Drosophila Gr5a encodes a taste receptor tuned to trehalose. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 14526-14530. PMID: 14523229, PMCID: PMC304113, DOI: 10.1073/pnas.2135339100.Peer-Reviewed Original ResearchConceptsG protein-coupled receptor genesDrosophila S2 cell lineS2 cell lineFirst functional expressionTaste receptorsHeterologous expressionGenetic analysisFunctional expressionGr5aTaste sensillaReceptor geneCell linesGenesLabellar sensillaExpressionSensillaTaste neuronsReceptorsRecent studiesLabellumSensory responsesFliesNeuronsTrehaloseFamily
1999
Odor Coding in a Model Olfactory Organ: TheDrosophila Maxillary Palp
de Bruyne M, Clyne P, Carlson J. Odor Coding in a Model Olfactory Organ: TheDrosophila Maxillary Palp. Journal Of Neuroscience 1999, 19: 4520-4532. PMID: 10341252, PMCID: PMC6782632, DOI: 10.1523/jneurosci.19-11-04520.1999.Peer-Reviewed Original ResearchConceptsReceptor neuronsOlfactory organOlfactory receptor neuronsCross-adaptation experimentsExcitatory responsesNeuronal typesExtracellular recordingsParticular neuronsNeuronsFunctional classSensilla typesOdor responsesOdor codingOlfactory informationOdor deliveryOrgansMaxillary palpsSensory hairsFunctional organizationSingle sensillaResponseDeliveryOlfactory codeParticular odorTwo-neuronThe Odor Specificities of a Subset of Olfactory Receptor Neurons Are Governed by Acj6, a POU-Domain Transcription Factor
Clyne P, Certel S, de Bruyne M, Zaslavsky L, Johnson W, Carlson J. The Odor Specificities of a Subset of Olfactory Receptor Neurons Are Governed by Acj6, a POU-Domain Transcription Factor. Neuron 1999, 22: 339-347. PMID: 10069339, DOI: 10.1016/s0896-6273(00)81094-6.Peer-Reviewed Original ResearchConceptsPOU domain transcription factorOlfactory neuronsTranscription factorsIndividual olfactory neuronsOdorant response profilesSubset of neuronsOlfactory receptor neuronsOdor specificityPhysiological analysisAcj6Neuronal identityOlfactory behaviorMolecular analysisReceptor neuronsNeuronsReceptor geneOlfactory codingGenesResponse profilesMutantsSpecificitySubset