2022
Ir56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila
Dweck HKM, Talross GJS, Luo Y, Ebrahim SAM, Carlson JR. Ir56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila. Current Biology 2022, 32: 1776-1787.e4. PMID: 35294865, PMCID: PMC9050924, DOI: 10.1016/j.cub.2022.02.063.Peer-Reviewed Original ResearchConceptsSalt tasteBitter-sensing neuronsStop codonLoss of functionNumber of speciesIonotropic receptorsIonotropic receptor familyN-terminal regionReceptor familyNeuronsDrosophila speciesPremature stop codonTaste modalitiesAncient functionGR familySalt responseSense codonsMolecular basisAtypical memberSalt detectionModalitiesCodonSensory modalitiesDrosophilaBehavioral responses
2019
Chemosensory sensilla of the Drosophila wing express a candidate ionotropic pheromone receptor
He Z, Luo Y, Shang X, Sun JS, Carlson JR. Chemosensory sensilla of the Drosophila wing express a candidate ionotropic pheromone receptor. PLOS Biology 2019, 17: e2006619. PMID: 31112532, PMCID: PMC6528970, DOI: 10.1371/journal.pbio.2006619.Peer-Reviewed Original ResearchConceptsMale-female interactionsDrosophila wingSubesophageal zoneWing marginChemosensory sensillaRNA-seq analysisDifferential RNA-seq analysisAnterior wing marginMale-male interactionsPheromone receptorsTaste organsOptogenetic activationMolecular descriptionGenesIonotropic receptorsChemical perceptionSensillaSecond-order projectionsSexual behaviorFliesPheromoneMale sexual behaviorPheromonal inputHydrophobic moleculesActivation
2014
The Drosophila IR20a Clade of Ionotropic Receptors Are Candidate Taste and Pheromone Receptors
Koh TW, He Z, Gorur-Shandilya S, Menuz K, Larter NK, Stewart S, Carlson JR. The Drosophila IR20a Clade of Ionotropic Receptors Are Candidate Taste and Pheromone Receptors. Neuron 2014, 83: 850-865. PMID: 25123314, PMCID: PMC4141888, DOI: 10.1016/j.neuron.2014.07.012.Peer-Reviewed Original ResearchConceptsPheromone receptorsIonotropic receptorsGustatory receptor genesMale mating behaviorAdaptive evolutionTaste neuronsMale forelegsDimorphic expressionConspecific femalesCladeMating behaviorReceptor geneGenesTaste organsFliesNeural circuitsTaste receptorsNeuronsReceptorsSexual behaviorExpressionDrosophilaInsectsComprehensive analysisCourtship