2023
Cx26 heterozygous mutations cause hyperacusis-like hearing oversensitivity and increase susceptibility to noise
Liu L, Liang C, Chen J, Fang S, Zhao H. Cx26 heterozygous mutations cause hyperacusis-like hearing oversensitivity and increase susceptibility to noise. Science Advances 2023, 9: eadf4144. PMID: 36753545, PMCID: PMC9908021, DOI: 10.1126/sciadv.adf4144.Peer-Reviewed Original ResearchConceptsActive cochlear amplificationCochlear amplificationHeterozygous mutationsPermanent hearing threshold shiftHearing threshold shiftCochlear lateral wallNonsyndromic hearing lossHearing lossMouse modelGeneral populationNoise exposureThreshold shiftHeterozygote carriersHearing sensitivityLateral wallJunction genesGap junction genesPotential generationUnexpected findingExposureMutationsOversensitivityProtein prestinDeafness
2016
Expression and function of pannexins in the inner ear and hearing
Zhao H. Expression and function of pannexins in the inner ear and hearing. BMC Molecular And Cell Biology 2016, 17: 16. PMID: 27229462, PMCID: PMC4896268, DOI: 10.1186/s12860-016-0095-7.Peer-Reviewed Original ResearchConceptsFunction of pannexinsAuditory sensory hair cellsDistinct expression patternsCell apoptotic pathwaysGap junction genesSensory hair cellsGap junction proteinGene familyATP releaseExpression patternsApoptotic pathwayEndocochlear potentialJunction genesPannexinsActive cochlear amplificationPannexin expressionLateral wallCochlear lateral wallJunction proteinsOrgan of CortiHair cellsCritical roleCochlear amplificationIsoformsStria vascularis
2009
Modulation of Outer Hair Cell Electromotility by Cochlear Supporting Cells and Gap Junctions
Yu N, Zhao H. Modulation of Outer Hair Cell Electromotility by Cochlear Supporting Cells and Gap Junctions. PLOS ONE 2009, 4: e7923. PMID: 19936276, PMCID: PMC2775161, DOI: 10.1371/journal.pone.0007923.Peer-Reviewed Original Research
2006
Distinct and gradient distributions of connexin26 and connexin30 in the cochlear sensory epithelium of guinea pigs
Zhao H, Yu N. Distinct and gradient distributions of connexin26 and connexin30 in the cochlear sensory epithelium of guinea pigs. The Journal Of Comparative Neurology 2006, 499: 506-518. PMID: 16998915, PMCID: PMC2553046, DOI: 10.1002/cne.21113.Peer-Reviewed Original ResearchConceptsCochlear sensory epitheliumSensory epitheliumGuinea pigsHensen's cellsDeiters' cellsSpiral ganglion neuronsPillar cellsExpression of Cx26Auditory sensory epitheliumDistinct cellular expressionGanglion neuronsCochlear apexCx26 labelingCell bodiesCx26 expressionImmunofluorescent stainingEpitheliumHair cellsCellular expressionCx30Dense labelingClaudius cellsCell preparationsPredominant isoformCellular distribution
2005
Gap junctional hemichannel-mediated ATP release and hearing controls in the inner ear
Zhao H, Yu N, Fleming C. Gap junctional hemichannel-mediated ATP release and hearing controls in the inner ear. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 18724-18729. PMID: 16344488, PMCID: PMC1317927, DOI: 10.1073/pnas.0506481102.Peer-Reviewed Original ResearchConceptsHemichannel-mediated ATP releaseHair cellsGap junctional blockerActive cochlear amplifierAuditory sensory hair cellsSensory hair cellsEffect of ATPP2 receptorsExtracellular Ca2OHC electromotilityCochlear sensitivityATP releaseConnexin gap junctionsExtracellular ATPConnexin expressionInner earImmunofluorescent stainingHearing controlsHearing sensitivityOuter hair cell electromotilityCochleaHair cell electromotilityConnexin hemichannelsCochlear fluidsGap junctional channels
2004
Paradoxical Enhancement of Active Cochlear Mechanics in Long-Term Administration of Salicylate
Huang Z, Luo Y, Wu Z, Tao Z, Jones R, Zhao H. Paradoxical Enhancement of Active Cochlear Mechanics in Long-Term Administration of Salicylate. Journal Of Neurophysiology 2004, 93: 2053-2061. PMID: 15590729, DOI: 10.1152/jn.00959.2004.Peer-Reviewed Original ResearchConceptsDistortion product otoacoustic emissionsLong-term administrationOtotoxic mechanismsLong-term salicylate administrationAwake guinea pigsReversible hearing lossSalicylate-induced tinnitusActive cochlear mechanicsProduct otoacoustic emissionsInitial normal levelsDistortion productsSalicylate administrationSodium salicylateDaily injectionsSaline injectionHearing functionHearing lossCubic distortion productSingle injectionControl animalsOHC levelsCommon drugsSalicylate treatmentAcoustic emissionRate of recovery