2020
Effects of Hypericum scabrum extract on dentate gyrus synaptic plasticity in high fat diet-fed rats
Omidi G, Rezvani-Kamran A, Ganji A, Komaki S, Etaee F, Asadbegi M, Komaki A. Effects of Hypericum scabrum extract on dentate gyrus synaptic plasticity in high fat diet-fed rats. The Journal Of Physiological Sciences 2020, 70: 19. PMID: 32209056, PMCID: PMC7093352, DOI: 10.1186/s12576-020-00747-0.Peer-Reviewed Original ResearchConceptsHigh-fat dietHigh-frequency stimulationExcitatory postsynaptic potentialsLong-term potentiationPerforant pathwayHypericum Scabrum extractSynaptic plasticityHFD groupPopulation spikesDentate gyrusEPSP slopePS amplitudeEffects of HFDField excitatory postsynaptic potentialsHigh-fat diet-fed ratsHippocampal synaptic plasticityMale Wistar ratsBipolar recording electrodesDiet-fed ratsDentate gyrus synaptic plasticityHippocampal neurogenesisNeuroprotective impactPostsynaptic potentialsWistar ratsControl group
2019
Investigation of protective effects of coenzyme Q10 on impaired synaptic plasticity in a male rat model of Alzheimer’s disease
Komaki H, Faraji N, Komaki A, Shahidi S, Etaee F, Raoufi S, Mirzaei F. Investigation of protective effects of coenzyme Q10 on impaired synaptic plasticity in a male rat model of Alzheimer’s disease. Brain Research Bulletin 2019, 147: 14-21. PMID: 30721766, DOI: 10.1016/j.brainresbull.2019.01.025.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyloid beta-PeptidesAnimalsAntioxidantsDentate GyrusDisease Models, AnimalExcitatory Postsynaptic PotentialsHippocampusLong-Term PotentiationMaleMemoryMemory DisordersNeuronal PlasticityNeuroprotective AgentsOxidative StressPeptide FragmentsRatsRats, WistarSynaptic TransmissionTemporal LobeUbiquinoneConceptsLong-term potentiationAlzheimer's diseaseSynaptic plasticityAβ injectionAβ groupOral gavageQ10 treatmentRat modelCoenzyme Q10Adult male Wistar ratsExcitatory postsynaptic potential slopeTotal antioxidant capacity levelsHippocampal long-term potentiationΒ-amyloid depositionSerum malondialdehyde levelsHippocampal dentate gyrusMale rat modelHippocampal synaptic plasticityMale Wistar ratsEffects of AβHigh-frequency stimulationAntioxidant capacity levelsVivo electrophysiological recordingsTotal oxidant levelsPotential adverse consequences