2010
Viral Infection of the Placenta Leads to Fetal Inflammation and Sensitization to Bacterial Products Predisposing to Preterm Labor
Cardenas I, Means RE, Aldo P, Koga K, Lang SM, Booth C, Manzur A, Oyarzun E, Romero R, Mor G. Viral Infection of the Placenta Leads to Fetal Inflammation and Sensitization to Bacterial Products Predisposing to Preterm Labor. The Journal Of Immunology 2010, 185: 1248-1257. PMID: 20554966, PMCID: PMC3041595, DOI: 10.4049/jimmunol.1000289.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBacterial InfectionsCell LineCells, CulturedCytokinesFemaleFetal DiseasesFetusHost-Pathogen InteractionsHumansImmunohistochemistryInflammationMaternal-Fetal ExchangeMiceMice, Inbred C57BLMice, KnockoutNIH 3T3 CellsObstetric Labor, PrematurePlacentaPlacenta DiseasesPregnancyPregnancy Complications, InfectiousRhadinovirusToll-Like Receptor 3Virus DiseasesConceptsViral infectionPreterm laborBacterial productsFetal inflammatory responseMaternal immune systemFetal transmissionFetal inflammationNonpregnant populationOrgan damagePregnant womenPregnant mothersPlacental unitInflammatory responseImmunological roleAnimal modelsImmune systemInfectionPlacentaMicrobial infectionsFetusesDevelopmental deficienciesMothersDetrimental effectsPandemicInflammation
2006
Attenuation of signaling pathways stimulated by pathologically activated FGF-receptor 2 mutants prevents craniosynostosis
Eswarakumar VP, Özcan F, Lew ED, Bae JH, Tomé F, Booth CJ, Adams DJ, Lax I, Schlessinger J. Attenuation of signaling pathways stimulated by pathologically activated FGF-receptor 2 mutants prevents craniosynostosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 18603-18608. PMID: 17132737, PMCID: PMC1693709, DOI: 10.1073/pnas.0609157103.Peer-Reviewed Original ResearchConceptsFGF receptorsDocking protein FRS2alphaCommon craniofacial abnormalitySelective uncouplingPremature fusionSkull developmentFunction mutationsDominant mutationsNormal skull developmentMurine model systemMutationsSevere bone disordersModel systemFGFR2cCraniofacial abnormalitiesCalvaria organ culturesPathwayOrgan cultureFRS2alphaSkull vaultMutantsPharmacological approachesFusionFGFRUncoupling