2007
The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching
Suchting S, Freitas C, le Noble F, Benedito R, Bréant C, Duarte A, Eichmann A. The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 3225-3230. PMID: 17296941, PMCID: PMC1805603, DOI: 10.1073/pnas.0611177104.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAmyloid Precursor Protein SecretasesAnimalsCalcium-Binding ProteinsEndothelium, VascularGamma-Aminobutyric AcidImmunohistochemistryIn Situ HybridizationIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceMice, Mutant StrainsReceptors, Vascular Endothelial Growth FactorRetinal VesselsSignal TransductionTriglyceridesVascular Endothelial Growth Factor AConceptsTip cell formationEndothelial tip cell formationTip cellsNotch ligand DeltaCell formationCell marker genesEndothelial tip cellsVessel branchingLigand DeltaExpression of Dll4Vascular network formationTransmembrane ligandsNotch receptorsMarker genesNegative regulatorAngiogenic sproutingVEGF receptor 2VEGF stimulationFilopodia extensionGamma-secretase inhibitorsGrowth factor VEGFVascular sproutingPharmacological inhibitionDll4Heterozygous deletion
2004
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
Lu X, le Noble F, Yuan L, Jiang Q, de Lafarge B, Sugiyama D, Bréant C, Claes F, De Smet F, Thomas JL, Autiero M, Carmeliet P, Tessier-Lavigne M, Eichmann A. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 2004, 432: 179-186. PMID: 15510105, DOI: 10.1038/nature03080.Peer-Reviewed Original ResearchConceptsNetrin receptor UNC5BEndothelial tip cell filopodiaTip cell filopodiaReceptor UNC5BEndothelial tip cellsVascular systemNetrin-1aTip cellsEndothelial cellsProper wiringAxon guidanceCell filopodiaNetrin receptorsGuidance eventsFilopodial retractionMorphogenesisUNC5BVessel branchingAberrant extensionAnatomical similaritiesNetrin-1CellsZebrafishGenesGuidance functionRetinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of Tie2 signaling in vascular progenitor cells
Suzuki Y, Komi Y, Ashino H, Yamashita J, Inoue J, Yoshiki A, Eichmann A, Amanuma H, Kojima S. Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of Tie2 signaling in vascular progenitor cells. Blood 2004, 104: 166-169. PMID: 15026310, DOI: 10.1182/blood-2003-09-3293.Peer-Reviewed Original ResearchConceptsVascular progenitor cellsAll-trans retinoic acidChicken chorioallantoic membraneEndothelial cellsTie2 signalingProgenitor cellsBlood vessel formationMural cellsEpithelial layerExpression of angiopoietin-2Vessel formationRetinoic acidImpaired vascular remodelingImpaired branchingAngiopoietin-2Ang-1Vascular remodelingRo41-5253Cell interactionsMural cell interactions
2001
Plasticity of endothelial cells during arterial-venous differentiation in the avian embryo.
Moyon D, Pardanaud L, Yuan L, Bréant C, Eichmann A. Plasticity of endothelial cells during arterial-venous differentiation in the avian embryo. Development 2001, 128: 3359-70. PMID: 11546752, DOI: 10.1242/dev.128.17.3359.Peer-Reviewed Original ResearchConceptsArterial-venous differentiationEndothelial plasticityEndothelial cellsEmbryonic day 7Jugular veinDay 7Vessel wallPrimary vascular systemNeuropilin-1Quail-chick chimerasHost arteryVenous fateEmbryonic developmentTransmembrane receptorsVenous markersEmbryonic day 2Venous endothelial cellsAortic endothelial cellsAvian embryosVascular developmentMost arteriesCarotid arteryVessel identityDay 11 embryosDorsal aortaSelective expression of angiopoietin 1 and 2 in mesenchymal cells surrounding veins and arteries of the avian embryo
Moyon D, Pardanaud L, Yuan L, Bréant C, Eichmann A. Selective expression of angiopoietin 1 and 2 in mesenchymal cells surrounding veins and arteries of the avian embryo. Cells And Development 2001, 106: 133-136. PMID: 11472842, DOI: 10.1016/s0925-4773(01)00425-7.Peer-Reviewed Original ResearchMeSH KeywordsAngiopoietin-1Angiopoietin-2AnimalsAortaArteriesChick EmbryoDown-RegulationEndothelium, VascularGene Expression Regulation, DevelopmentalHeartIn Situ HybridizationLymphatic SystemMembrane GlycoproteinsMesodermNeoplasm ProteinsProteinsProto-Oncogene ProteinsQuailReceptor, TIE-2RNA, MessengerVeins
2000
Hemangioblastic Precursors in the Avian Embryo
Eichmann A, Corbel C, Pardanaud L, Bréant C, Moyon D, Yuan L. Hemangioblastic Precursors in the Avian Embryo. Current Topics In Microbiology And Immunology 2000, 251: 83-90. PMID: 11036762, DOI: 10.1007/978-3-642-57276-0_11.Peer-Reviewed Original ResearchConceptsBlood islandsHemangioblastic precursorsHemopoietic cellsVascular endothelial growth factor receptor 2Embryonic yolk sacBlood island formationEndothelial cellsMesodermal cellsEndothelial growth factor receptor 2Avian embryosCell typesExtraembryonic areasYolk sacCommon precursorChick blastodermExternal cellsCellsInternal cellsRecent evidenceGrowth factor receptor 2Factor receptor 2Receptor 2HemangioblastsIslandsBlastoderm
1999
Endothelial cell precursors in the avian embryo.
Eichmann A, Corbel C. Endothelial cell precursors in the avian embryo. Current Research In Translational Medicine 1999, 47: 307-13. PMID: 10372398.Peer-Reviewed Original ResearchConceptsAvian embryosEndothelial cellsEndothelial cell precursorsGastrulation stagePosterior mesodermGrowth factorDevelopmental biologySpecific growth factorsVascular endothelial growth factorOnly endothelial cellsMolecular mechanismsHematopoietic cellsEmbryosCell precursorsCulture experimentsSignificant insightsEndothelial growth factorVascular systemCellsVEGFR2-positive cellsMesodermMammalsAngioblastsReceptorsBiologyRécepteurs et développement des cellules endothéliales et hématopoïétiques
Eichmann A, Moyon D, Corbel C. Récepteurs et développement des cellules endothéliales et hématopoïétiques. Biologie Aujourd Hui 1999, 193: 155-157. PMID: 10451349, DOI: 10.1051/jbio/1999193020155.Peer-Reviewed Original Research
1998
Segregation of the embryonic vascular and hemopoietic systems
Eichmann A, Corbel C, Le Douarin N. Segregation of the embryonic vascular and hemopoietic systems. Biochemistry And Cell Biology 1998, 76: 939-946. PMID: 10392707, DOI: 10.1139/o98-106.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCell DifferentiationChick EmbryoEmbryo, NonmammalianEndothelial Growth FactorsEndothelium, VascularHematopoietic Stem CellsLymphokinesMesodermMiceModels, CardiovascularQuailReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, Vascular Endothelial Growth FactorVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsEndothelial precursor cellsAvian embryosPrecursor cellsVEGF receptor VEGFR2Primary vascular systemEndothelial cellsGastrulation stageGrowth factorDevelopmental biologyVertebrate classesSpecific growth factorsVascular endothelial growth factorAngiogenic vascular endothelial growth factorMouse embryosMolecular mechanismsCognate receptorsSubsequent assemblyHemopoietic cellsEmbryosReceptor VEGFR2Hemopoietic systemCulture experimentsVEGFR2CellsSignificant insightsIntraaortic hemopoietic cells are derived from endothelial cells during ontogeny
Jaffredo T, Gautier R, Eichmann A, Dieterlen-Lièvre F. Intraaortic hemopoietic cells are derived from endothelial cells during ontogeny. Development 1998, 125: 4575-4583. PMID: 9778515, DOI: 10.1242/dev.125.22.4575.Peer-Reviewed Original ResearchAvian VEGF-C: cloning, embryonic expression pattern and stimulation of the differentiation of VEGFR2-expressing endothelial cell precursors
Eichmann A, Corbel C, Jaffredo T, Bréant C, Joukov V, Kumar V, Alitalo K, le Douarin N. Avian VEGF-C: cloning, embryonic expression pattern and stimulation of the differentiation of VEGFR2-expressing endothelial cell precursors. Development 1998, 125: 743-752. PMID: 9435294, DOI: 10.1242/dev.125.4.743.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceCell DifferentiationCloning, MolecularDNA, ComplementaryEndothelial Growth FactorsEndothelium, VascularGene Expression Regulation, DevelopmentalIn Situ HybridizationMesodermMiceMolecular Sequence DataProtein BindingQuailReceptor Protein-Tyrosine KinasesReceptors, Cell SurfaceReceptors, Growth FactorReceptors, Vascular Endothelial Growth FactorRecombinant ProteinsSequence Homology, Amino AcidStem CellsVascular Endothelial Growth Factor CVascular Endothelial Growth Factor Receptor-3
1997
Ligand-dependent development of the endothelial and hemopoietic lineages from embryonic mesodermal cells expressing vascular endothelial growth factor receptor 2
Eichmann A, Corbel C, Nataf V, Vaigot P, Bréant C, Le Douarin N. Ligand-dependent development of the endothelial and hemopoietic lineages from embryonic mesodermal cells expressing vascular endothelial growth factor receptor 2. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 5141-5146. PMID: 9144204, PMCID: PMC24645, DOI: 10.1073/pnas.94.10.5141.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalCell DifferentiationChick EmbryoEndothelial Growth FactorsEndothelium, VascularGastrulaHematopoietic Stem CellsHomozygoteLigandsLymphokinesMesodermMiceMice, Inbred BALB CMice, KnockoutQuailReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, Vascular Endothelial Growth FactorVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsVascular endothelial growth factor receptor 2VEGFR2 ligandsEndothelial growth factor receptor 2Embryonic mesodermal cellsVascular endothelial lineageHemopoietic cellsDevelopmental decisionsGastrulation stageHomozygous null miceMesodermal cellsAbsence of VEGFGene productsGene targetingNull mutationEndothelial lineageHemopoietic differentiationExtracellular domainClonal culturesLineagesHemopoietic lineagesEndothelial differentiationEndothelial cell coloniesCell coloniesCell microenvironmentGrowth factor receptor 2Expression of the avian VEGF receptor homologues Quek1 and Quek2 in blood-vascular and lymphatic endothelial and non-endothelial cells during quail embryonic development
Wilting J, Eichmann A, Christ B. Expression of the avian VEGF receptor homologues Quek1 and Quek2 in blood-vascular and lymphatic endothelial and non-endothelial cells during quail embryonic development. Cell And Tissue Research 1997, 288: 207-223. PMID: 9082957, DOI: 10.1007/s004410050807.Peer-Reviewed Original Research
1996
VEGF121Induces Proliferation of Vascular Endothelial Cells and Expression offlk-1without Affecting Lymphatic Vessels of the Chorioallantoic Membrane
Wilting J, Birkenhäger R, Eichmann A, Kurz H, Martiny-Baron G, Marmé D, McCarthy J, Christ B, Weich H. VEGF121Induces Proliferation of Vascular Endothelial Cells and Expression offlk-1without Affecting Lymphatic Vessels of the Chorioallantoic Membrane. Developmental Biology 1996, 176: 76-85. PMID: 8654896, DOI: 10.1006/dbio.1996.9993.Peer-Reviewed Original ResearchAllantoisAnimalsCell DivisionChick EmbryoChorionCoturnixEndothelial Growth FactorsEndothelium, VascularGene Expression Regulation, DevelopmentalIn Situ HybridizationLymphatic SystemLymphokinesMicroscopy, ElectronMitogensNeovascularization, PhysiologicProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, Vascular Endothelial Growth FactorVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth Factors
1995
The angiogenic potentials of the cephalic mesoderm and the origin of brain and head blood vessels
Couly G, Coltey P, Eichmann A, Le Douarin N. The angiogenic potentials of the cephalic mesoderm and the origin of brain and head blood vessels. Cells And Development 1995, 53: 97-112. PMID: 8555115, DOI: 10.1016/0925-4773(95)00428-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalBrainChick EmbryoCoturnixEndothelium, VascularHeadMesodermNeovascularization, PhysiologicStem CellsTransplantation, HeterologousConceptsCephalic paraxial mesodermParaxial mesodermCephalic mesodermAnterior paraxial mesodermBlood vessel endothelial cellsQuail-chick chimera techniqueVessel endothelial cellsEarly avian embryoEndothelial cellsOrigin of brainGastrulation stageMesodermal territoryMesodermal cellsQuail speciesAngiogenic potentialMesodermNeural crestNeural primordiumMolecular markersAvian embryosAvian homologueHigh growth rateStage-matched embryosHemopoietic cellsFlk-1
1993
Two molecules related to the VEGF receptor are expressed in early endothelial cells during avian embryonic development
Eichmann A, Marcelle C, Bréant C, Le Douarin N. Two molecules related to the VEGF receptor are expressed in early endothelial cells during avian embryonic development. Cells And Development 1993, 42: 33-48. PMID: 8396413, DOI: 10.1016/0925-4773(93)90096-g.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceChick EmbryoCloning, MolecularEmbryo, NonmammalianEndothelium, VascularMolecular Sequence DataProtein-Tyrosine KinasesQuailReceptor Protein-Tyrosine KinasesReceptors, MitogenReceptors, NeurotransmitterReceptors, Vascular Endothelial Growth FactorSequence Homology, Nucleic AcidVascular Endothelial Growth Factor Receptor-2ConceptsExpression patternsOnset of gastrulationAvian embryonic developmentEndothelial cellsEarly endothelial cellsMonoclonal antibody QH1Human genesEmbryonic developmentEmbryonic day 9Vascular endothelial growth factorHigh homologyHematopoietic lineagesAvian embryosPartial cloningSitu hybridizationReceptor moleculesGastrulationPutative precursorEndothelial cell mitogen vascular endothelial growth factorFlk-1GenesEmbryosGrowth factorQH1VEGF receptors