2022
Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-analysis
Bas-Hoogendam J, Bernstein R, Benson B, Buss K, Gunther K, Pérez-Edgar K, Salum G, Jackowski A, Bressan R, Zugman A, Degnan K, Filippi C, Fox N, Henderson H, Tang A, Zeytinoglu S, Harrewijn A, Hillegers M, White T, van IJzendoorn M, Schwartz C, Felicione J, DeYoung K, Shackman A, Smith J, Tillman R, van den Berg Y, Cillessen A, Roelofs K, Tyborowska A, Hill S, Battaglia M, Tettamanti M, Dougherty L, Jin J, Klein D, Leung H, Avery S, Blackford J, Clauss J, Hayden E, Liu P, Vandermeer M, Goldsmith H, Planalp E, Nichols T, Thompson P, Westenberg P, van der Wee N, Groenewold N, Stein D, Winkler A, Pine D, Group E. Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-analysis. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 61: 1182-1188. PMID: 36038199, PMCID: PMC9434711, DOI: 10.1016/j.jaac.2022.04.023.Peer-Reviewed Original ResearchConceptsStructural brain correlatesSelf-report questionnairesTendency of individualsInhibited temperamentBehavioral inhibitionBrain correlatesUnfamiliar peopleDirect behavioral observationsEmotional tendencyTemperamentTemperament classificationEarly childhoodBehavioral observationsUnexpected eventsRetrospective levelsIndividualsUnfamiliarCorrelatesCaregiversTendencyRelateFirst yearChildhoodInfancyLife
2020
Amygdala Functional Connectivity and Negative Reactive Temperament at Age 4 Months
Filippi C, Ravi S, Bracy M, Winkler A, Sylvester C, Pine D, Fox N. Amygdala Functional Connectivity and Negative Reactive Temperament at Age 4 Months. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 60: 1137-1146. PMID: 33385507, PMCID: PMC8239057, DOI: 10.1016/j.jaac.2020.11.021.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxietyHumansInfantMagnetic Resonance ImagingPrefrontal CortexTemperamentConceptsAmygdala connectivityPositive affectNegative affectParent reportChild-reported anxiety symptomsCognitive control mechanismsFunctional magnetic resonance imagingWhole-brain voxelwise approachLow positive affectAmygdala functional connectivityResting-state functional magnetic resonance imagingIndependent longitudinal samplesReactivity assessmentTemperamental riskReactive temperamentInfant temperamentAnxiety symptomsConnectivity correlatesLongitudinal sampleFunctional connectivityMaternal reportsNegative reactivityAffectTemperamentDistress