2014
Assessment of whole brain white matter integrity in youths and young adults with a family history of substance‐use disorders
Acheson A, Wijtenburg S, Rowland L, Winkler A, Gaston F, Mathias C, Fox P, Lovallo W, Wright S, Hong L, Dougherty D, Kochunov P. Assessment of whole brain white matter integrity in youths and young adults with a family history of substance‐use disorders. Human Brain Mapping 2014, 35: 5401-5413. PMID: 24867528, PMCID: PMC4206569, DOI: 10.1002/hbm.22559.Peer-Reviewed Original ResearchConceptsSubstance use disordersLower FA valuesFamily historyUse disordersFA valuesCorona radiataWhole-brain white matter integrityYoung adultsFrontostriatal white matter tractsBrain white matter integrityFrontal white matterPosterior corona radiataAnterior corona radiataFractional anisotropy (FA) dataHigher radial diffusivitySuch family historyWhite matter tractsWhite matter integrityAge-related declineImpaired myelinationAxonal myelinationCorpus callosumGeneral populationWhite matterSignificant negative correlation
2010
A Multimodal Assessment of the Genetic Control over Working Memory
Karlsgodt KH, Kochunov P, Winkler AM, Laird AR, Almasy L, Duggirala R, Olvera RL, Fox PT, Blangero J, Glahn DC. A Multimodal Assessment of the Genetic Control over Working Memory. Journal Of Neuroscience 2010, 30: 8197-8202. PMID: 20554870, PMCID: PMC2894480, DOI: 10.1523/jneurosci.0359-10.2010.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnisotropyBrainBrain MappingDiffusion Magnetic Resonance ImagingFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMemory, Short-TermMexican AmericansMiddle AgedNerve Fibers, MyelinatedNeural PathwaysNeuropsychological TestsOxygenPedigreeYoung AdultConceptsMemory performanceComplex cognitive functionsHigher-level processesGray matter densityWorking memoryCognitive measuresResponse taskStructural magnetic resonanceGeneral intelligenceSuperior longitudinal fasciculusHuman participantsWhite matter tractsCognitive functionCognitive deficitsOnly performanceMultimodal assessmentBrain regionsMemoryCommon genetic factorsLongitudinal fasciculusMajor white matter tractsLevel processesMeasuresGray matter regionsCore component