2019
Accelerated estimation and permutation inference for ACE modeling
Chen X, Formisano E, Blokland G, Strike L, McMahon K, de Zubicaray G, Thompson P, Wright M, Winkler A, Ge T, Nichols T. Accelerated estimation and permutation inference for ACE modeling. Human Brain Mapping 2019, 40: 3488-3507. PMID: 31037793, PMCID: PMC6680147, DOI: 10.1002/hbm.24611.Peer-Reviewed Original ResearchConceptsPermutation inferenceIterative optimizationVariance component modelComputation timeComparable biasAccelerated estimationLinear modelSquared errorCluster sizeSpatial statisticsLinear regression modelsFalse positive riskInferenceHeritability estimationEstimationComponent modelModelWealth of toolsMemory datasetsOptimizationSimple methodSmall numberStatisticsACE modelPermutations
2015
Fast and powerful heritability inference for family-based neuroimaging studies
Ganjgahi H, Winkler AM, Glahn DC, Blangero J, Kochunov P, Nichols TE. Fast and powerful heritability inference for family-based neuroimaging studies. NeuroImage 2015, 115: 256-268. PMID: 25812717, PMCID: PMC4463976, DOI: 10.1016/j.neuroimage.2015.03.005.Peer-Reviewed Original ResearchConceptsAuxiliary linear modelSemi-parametric inferenceInference methodsP-value computationParametric inference methodsNovel inference methodSum of squaresMultiple testing problemLikelihood computationInference proceduresFast estimationStandard resultsComputational intensityData settingTesting problemLinear modelPermutation schemeMethodological resultsAnisotropy measuresSignificance testsComputationInferenceWald testFalse positive riskHeritability estimation