2021
An In-vivo 1H-MRS short-echo time technique at 7T: Quantification of metabolites in chronic multiple sclerosis and neuromyelitis optica brain lesions and normal appearing brain tissue
Tackley G, Kong Y, Minne R, Messina S, Winkler A, Cavey A, Everett R, DeLuca G, Weir A, Craner M, Tracey I, Palace J, Stagg C, Emir U. An In-vivo 1H-MRS short-echo time technique at 7T: Quantification of metabolites in chronic multiple sclerosis and neuromyelitis optica brain lesions and normal appearing brain tissue. NeuroImage 2021, 238: 118225. PMID: 34062267, PMCID: PMC7611458, DOI: 10.1016/j.neuroimage.2021.118225.Peer-Reviewed Original ResearchConceptsTotal N-acetylaspartateMultiple sclerosisN-acetylaspartateBrain lesionsPositive neuromyelitis optica spectrum disorderWhite matterNeuromyelitis optica spectrum disorderOptica spectrum disorderChronic multiple sclerosisPost-hoc testingBrain white matterDisease groupMRS methodologyMRS profilesMRS studiesReciprocal findingsNon-invasive quantificationBrain tissueLesionsMagnetic resonance spectroscopyMyo-inositolDistinct diseasesNormal tissuesCNS moleculesIn-Vivo
2016
Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia
Kochunov P, Ganjgahi H, Winkler A, Kelly S, Shukla D, Du X, Jahanshad N, Rowland L, Sampath H, Patel B, O'Donnell P, Xie Z, Paciga S, Schubert C, Chen J, Zhang G, Thompson P, Nichols T, Hong L. Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia. Human Brain Mapping 2016, 37: 4673-4688. PMID: 27477775, PMCID: PMC5118078, DOI: 10.1002/hbm.23336.Peer-Reviewed Original ResearchConceptsAge-related declineWhite matterSchizophrenia patientsFractional anisotropyFA valuesDiagnosis interactionFaster age-related declinePathophysiology of schizophreniaHum Brain MappEffect of diagnosisLower fractional anisotropyPatient-control differencesT Siemens MRI scannerBrain white matterClinical burdenRegional FA valuesPatientsAbnormal rateBrain connectivityTract developmentAdolescent maturationSpecific tractsRegional reductionDiagnosisSchizophrenia