2023
Cognitive, Behavioral, and Circadian Rhythm Interventions for Insomnia Alter Emotional Brain Responses
Leerssen J, Aghajani M, Bresser T, Rösler L, Winkler A, Foster-Dingley J, Van Someren E. Cognitive, Behavioral, and Circadian Rhythm Interventions for Insomnia Alter Emotional Brain Responses. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 60-69. PMID: 36958474, DOI: 10.1016/j.bpsc.2023.03.007.Peer-Reviewed Original ResearchConceptsAmygdala responseSleep interventionsEmotion-related brain activityFunctional magnetic resonance imaging studyEmotional brain responsesInsomnia treatmentFunctional magnetic resonance imagingCognitive behavioral therapyMagnetic resonance imaging studyEmotional stimuliResonance imaging studyBrain mechanismsIndividual differencesPrevention of depressionCircadian interventionsBrain responsesEmotional stabilityBehavioral therapyAnxiety severityBrain activityBrain responsivenessLeft insulaInsomnia disorderHigh riskInsomnia symptoms
2022
Computational modeling of threat learning reveals links with anxiety and neuroanatomy in humans
Abend R, Burk D, Ruiz S, Gold A, Napoli J, Britton J, Michalska K, Shechner T, Winkler A, Leibenluft E, Pine D, Averbeck B. Computational modeling of threat learning reveals links with anxiety and neuroanatomy in humans. ELife 2022, 11: e66169. PMID: 35473766, PMCID: PMC9197395, DOI: 10.7554/elife.66169.Peer-Reviewed Original ResearchConceptsThreat learningAnxiety severitySafety learningNeuroanatomical substratesGreater anxiety severitySkin conductance dataThreat conditioningThreat extinctionThreat generalizationGray matter volumeSafe stimuliAssociative learningComputational mechanismsAnxiety symptomsAnxiety disordersInfluential theoriesSlower extinctionComputational modelLearningWhole brain anatomyAnxietyComputational modelingStructural imagingStimuliTask
2017
Anxiety modulates the relation between attention-deficit/hyperactivity disorder severity and working memory-related brain activity
van der Meer D, Hoekstra P, van Rooij D, Winkler A, van Ewijk H, Heslenfeld D, Oosterlaan J, Faraone S, Franke B, Buitelaar J, Hartman C. Anxiety modulates the relation between attention-deficit/hyperactivity disorder severity and working memory-related brain activity. The World Journal Of Biological Psychiatry 2017, 19: 450-460. PMID: 28635543, PMCID: PMC5581282, DOI: 10.1080/15622975.2017.1287952.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnxietyAnxiety DisordersAttention Deficit Disorder with HyperactivityCerebellumChildCognitive DysfunctionCohort StudiesComorbidityCorpus StriatumFemaleFunctional NeuroimagingHumansMagnetic Resonance ImagingMaleMemory, Short-TermSeverity of Illness IndexThalamusYoung AdultConceptsAttention-deficit/hyperactivity disorderCo-occurring anxietyADHD severityNeural activityMemory taskAttention-deficit/hyperactivity disorder severityMemory-related brain activityPresence of ADHDVisuospatial Working Memory TaskWorking Memory TaskLevel of anxietyVSWM tasksMemory loadHyperactivity disorderTask accuracyPrevious theorisingAnxiety severityBrain activityNeurobiological heterogeneityDisorder severityAnxietyWorse performanceInformation gatingYoung adultsNeural pathways