2024
Artificial Intelligence Predicts Hospitalization for Acute Heart Failure Exacerbation in Patients Undergoing Myocardial Perfusion Imaging
Feher A, Bednarski B, Miller R, Shanbhag A, Lemley M, Miras L, Sinusas A, Miller E, Slomka P. Artificial Intelligence Predicts Hospitalization for Acute Heart Failure Exacerbation in Patients Undergoing Myocardial Perfusion Imaging. Journal Of Nuclear Medicine 2024, 65: jnumed.123.266761. PMID: 38548351, PMCID: PMC11064832, DOI: 10.2967/jnumed.123.266761.Peer-Reviewed Original ResearchConceptsMyocardial perfusion imagingHF hospitalizationHeart failureStress left ventricular ejection fractionPerfusion imagingHF exacerbationPredictive of HF hospitalizationsSPECT/CT myocardial perfusion imagingMyocardial perfusionInternational cohortAcute heart failure exacerbationMedian follow-upVentricular ejection fractionReceiver-operating-characteristic curveClinical risk factorsHeart failure exacerbationExternal validation cohortAcute HF exacerbationPrevent HF hospitalizationsImaging parametersCalcium scoreEjection fractionClinical parametersCT scanValidation cohortImpact of cardiac size on diagnostic performance of single-photon emission computed tomography myocardial perfusion imaging: insights from the REgistry of Fast Myocardial Perfusion Imaging with NExt generation single-photon emission computed tomography
Randazzo M, Elias P, Poterucha T, Sharir T, Fish M, Ruddy T, Kaufmann P, Sinusas A, Miller E, Bateman T, Dorbala S, Di Carli M, Castillo M, Liang J, Miller R, Dey D, Berman D, Slomka P, Einstein A. Impact of cardiac size on diagnostic performance of single-photon emission computed tomography myocardial perfusion imaging: insights from the REgistry of Fast Myocardial Perfusion Imaging with NExt generation single-photon emission computed tomography. European Heart Journal - Cardiovascular Imaging 2024, 25: 996-1006. PMID: 38445511, PMCID: PMC11210974, DOI: 10.1093/ehjci/jeae055.Peer-Reviewed Original ResearchSPECT myocardial perfusion imagingMyocardial perfusion imagingCoronary artery diseaseCardiac sizeDetect obstructive coronary artery diseasePerfusion imagingObstructive coronary artery diseaseDetection of coronary artery diseaseNegative predictive valueLeft ventricular volumeSolid-state scannersSmall cardiac sizeCoronary angiographyMale patientsYounger patientsElderly patientsMale sexDiagnostic performanceVentricular volumeArtery diseaseVisual assessmentPatientsPredictive valueElderly ageSPECT
2023
Comparison of the prognostic value between quantification and visual estimation of coronary calcification from attenuation CT in patients undergoing SPECT myocardial perfusion imaging
Feher A, Pieszko K, Shanbhag A, Lemley M, Miller R, Huang C, Miras L, Liu Y, Gerber J, Sinusas A, Miller E, Slomka P. Comparison of the prognostic value between quantification and visual estimation of coronary calcification from attenuation CT in patients undergoing SPECT myocardial perfusion imaging. The International Journal Of Cardiovascular Imaging 2023, 40: 185-193. PMID: 37845406, PMCID: PMC466934, DOI: 10.1007/s10554-023-02980-1.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsCoronary artery calcificationMyocardial perfusion imagingCT myocardial perfusion imagingSPECT/CT myocardial perfusion imagingArtery calcificationPrognostic valuePrior coronary stentingAdverse cardiovascular eventsSimilar prognostic valueSPECT myocardial perfusionREFINE SPECT registrySPECT/CTCardiovascular eventsCAC scoringCalcium scoreCoronary calcificationCoronary stentingPrognostic utilitySingle centerCoronary arteryLow doseMyocardial perfusionPerfusion imagingSurvival analysisTime and event-specific deep learning for personalized risk assessment after cardiac perfusion imaging
Pieszko K, Shanbhag A, Singh A, Hauser M, Miller R, Liang J, Motwani M, Kwieciński J, Sharir T, Einstein A, Fish M, Ruddy T, Kaufmann P, Sinusas A, Miller E, Bateman T, Dorbala S, Di Carli M, Berman D, Dey D, Slomka P. Time and event-specific deep learning for personalized risk assessment after cardiac perfusion imaging. Npj Digital Medicine 2023, 6: 78. PMID: 37127660, PMCID: PMC10151323, DOI: 10.1038/s41746-023-00806-x.Peer-Reviewed Original ResearchAcute coronary syndromeMajor adverse cardiovascular eventsMyocardial perfusion imagingCause deathAdverse cardiovascular eventsModifiable risk factorsPrediction of deathPersonalized risk assessmentCardiovascular eventsCoronary syndromeClinical featuresPrognostic valueRisk factorsExternal cohortStandard clinical interpretationPerfusion imagingAbnormality measuresCardiac perfusionTime pointsPatients' explanationsClinical interpretationExternal validationDeathPatientsRisk assessmentUnsupervised learning to characterize patients with known coronary artery disease undergoing myocardial perfusion imaging
Williams M, Bednarski B, Pieszko K, Miller R, Kwiecinski J, Shanbhag A, Liang J, Huang C, Sharir T, Dorbala S, Di Carli M, Einstein A, Sinusas A, Miller E, Bateman T, Fish M, Ruddy T, Acampa W, Hauser M, Kaufmann P, Dey D, Berman D, Slomka P. Unsupervised learning to characterize patients with known coronary artery disease undergoing myocardial perfusion imaging. European Journal Of Nuclear Medicine And Molecular Imaging 2023, 50: 2656-2668. PMID: 37067586, PMCID: PMC10317876, DOI: 10.1007/s00259-023-06218-z.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseMyocardial perfusion imagingCause mortalityTotal perfusion deficitArtery diseaseRisk stratificationPerfusion deficitsHigher body mass indexTomography myocardial perfusion imagingMore diabetes mellitusSPECT myocardial perfusion imagingBetter risk stratificationRisk-stratify patientsBody mass indexREFINE SPECT registrySingle photon emissionDiabetes mellitusMass indexExternal cohortStress imagingMyocardial perfusionPatientsRisk phenotypePerfusion imagingImaging characteristicsIN PATIENTS UNDERGOING NUCLEAR MYOCARDIAL PERFUSION IMAGING, RHEUMATOID ARTHRITIS IS ASSOCIATED WITH INCREASED RISK OF ADVERSE CARDIOVASCULAR EVENTS INDEPENDENT OF MYOCARDIAL ISCHEMIA
Pires J, Oikonomou E, Agarwal R, Liu Y, miller E, Sinusas A, Feher A. IN PATIENTS UNDERGOING NUCLEAR MYOCARDIAL PERFUSION IMAGING, RHEUMATOID ARTHRITIS IS ASSOCIATED WITH INCREASED RISK OF ADVERSE CARDIOVASCULAR EVENTS INDEPENDENT OF MYOCARDIAL ISCHEMIA. Journal Of The American College Of Cardiology 2023, 81: 1467. DOI: 10.1016/s0735-1097(23)01911-3.Peer-Reviewed Original Research
2020
Coronary Computed Tomography Angiography Compared With Single Photon Emission Computed Tomography Myocardial Perfusion Imaging as a Guide to Optimal Medical Therapy in Patients Presenting With Stable Angina: The RESCUE Trial
Stillman A, Gatsonis C, Lima J, Liu T, Snyder B, Cormack J, Malholtra V, Schnall M, Udelson J, Hoffmann U, Woodard P, Kim M, Hegde V, Kenny, Afaq M, Clouse M, Malhotra V, Cole, Al‐Khori F, Scherer M, Rothenberg F, Kirsch J, Shah A, Quyyumi A, Engberding N, Becker C, Li D, Pantelic M, Duerinckx A, Martin, Schrank J, Zachariah, Jacob R, Borges A, Roberge E, Truong Q, Edelman R, Akers S, Marsh K, Kemp, Reingold J, Chilakapati V, Osborne J, Lui K, Gomes A, Bajpai A, del Rio J, Singh, Thompson B, Rivard A, Jha S, Mavromatis K, Woodard P, Sinusas A. Coronary Computed Tomography Angiography Compared With Single Photon Emission Computed Tomography Myocardial Perfusion Imaging as a Guide to Optimal Medical Therapy in Patients Presenting With Stable Angina: The RESCUE Trial. Journal Of The American Heart Association 2020, 9: e017993. PMID: 33283579, PMCID: PMC7955393, DOI: 10.1161/jaha.120.017993.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsOptimal medical therapyAcute myocardial infarctionMedical therapyStable anginaMyocardial perfusion imagingMyocardial infarctionSingle photon emissionNegative CCTAHazard ratioRescue trialPerfusion imagingFirst major adverse cardiovascular eventTomography myocardial perfusion imagingSPECT myocardial perfusion imagingAdverse cardiovascular eventsOutcomes of patientsTomography myocardial perfusionFirst imaging testPhoton emissionCCTA armPositive CCTACardiovascular eventsSegment involvementOutcome trials
2001
Technetium-99m-labeled Myocardial Perfusion Agents: Are They Better than Thallium-201?
Kailasnath P, Sinusas A. Technetium-99m-labeled Myocardial Perfusion Agents: Are They Better than Thallium-201? Cardiology In Review 2001, 9: 160-172. PMID: 11304401, DOI: 10.1097/00045415-200105000-00009.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePerfusion tracerPerfusion agentArtery diseaseMyocardial viabilityThallium-201Perfusion imagingMyocardial perfusion imagingRegional flow heterogeneityPharmacologic stressorChest painMyocardial perfusion agentRisk stratificationAcute assessmentNew perfusion agentTechnetium-99mClinical valueMyocardial uptakeIschemic regionAssessment of viabilityCoronary vasculatureMyocardial flowClearance kineticsMyocardial retentionTracer availability
1995
962-67 Dobutamine Stress has a Limited Value for Enhancing Flow Heterogeneity in the Presence of a Moderate Stenosis When Used in Conjunction with Tc99m-Sestamibi Imaging
Yun J, Wu J, Heller E, Deckelbaum L, Dione D, Liu Y, Wackers F, Sinusas A. 962-67 Dobutamine Stress has a Limited Value for Enhancing Flow Heterogeneity in the Presence of a Moderate Stenosis When Used in Conjunction with Tc99m-Sestamibi Imaging. Journal Of The American College Of Cardiology 1995, 25: 217a. DOI: 10.1016/0735-1097(95)92360-h.Peer-Reviewed Original ResearchMB activityModerate stenosisDOB stressMean aortic pressureOpen-chest dogsSPECT perfusion imagingLCX stenosisProximal LCXPeak dobutamineAortic pressureDobutamine stressMB injectionChest dogsHeart rateNonischemicStenosisDobutamineIschemic regionPerfusion imagingFlow probeRadiolabeled microspheresFlow deficitsMicrosphere flowLimited valueBaseline