Amygdala; Neuropharmacology; Neurophysiology; Social Behavior; Prefrontal Cortex; Psychiatry and Psychology
How do we interact with others, and why?
Our brains evolved to deal with increasing demands of dynamic social interactions. Social behaviors are heavily reinforcement driven, whether their motivating factors are physical rewards, such as food and sex, or more abstract rewards, such as vicarious experience and interpersonal reputation. Investigating how the brain computes social preferences and decisions can offer an ecologically valid and efficient way of unlocking the mystery of the mind. Elucidating the neural basis of social behavior will ultimately help treat social deficits in numerous psychiatric disorders.
Our research is aimed at understanding the neural mechanisms responsible for social cognition. Our laboratory focuses on how reward-related areas of the brain signal social preferences and generate social decisions. To answer our questions, we apply both neurophysiological and neuroendocrinological approaches during social interactions. We investigate neuronal representations as well as neuromodulator actions (e.g., oxytocin, serotonin) in the reward-related brain regions during social behavior. In a subset of topics, we also investigate similar neural processes using neuroimaging techniques.
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- Neural mechanisms of social interaction and social decision-making
- single-unit recording from the prefrontal cortex and the amygdala
- neurobiology of oxytocin-mediated social cognition
- combined neurophysiology and neuropharmacology
- neuroethology of social behavior
- reference frames and sensory-to-motor transformation
- The effects of 5-hydroxytryptophan on attention and central serotonin neurochemistry in the rhesus macaque Weinberg-Wolf H, Fagan NA, Anderson GM, Tringides M, Dal Monte O and Chang SWC (2018) Neuropsychopharmacology, DOI: 10.1038/s41386-017-0003-7
An emerging field of primate social neurophysiology: Current developments
Chang, SWC (2017). eNeuro, 4, e0295
Oxytocin under opioid antagonism leads to supralinear enhancement of social attention
Dal Monte O*, Piva M*, Anderson KM, Tringides M, Holmes AJ, Chang SWC. (2017) Proc. Natl. Acad. Sci., 114, 5247-5252. (*equal contributions)
Live interaction distinctively shapes social gaze dynamics in rhesus macaques
Dal Monte O*, Piva M*, Morris JA, Chang SWC (2016) J. Neurophys., 116, 1626 –1643. (* equal contributions)
The anterior cingulate gyrus and social cognition: Tracking the motivation of others
Apps MA, Rushworth MF, Chang SWC (2016) Neuron, 90(4), 692-707.
Neural mechanisms of social decision-making in the primate amygdala
Chang SWC, Fagan NA, Toda K, Utevsky AV, Pearson JM, Platt ML (2015) Proc. Natl. Acad. Sci., 112(52), 16012-16017.
Neuronal reference frames for social decisions in primate frontal cortex
Chang SWC, Gariépy JF and Platt ML (2013) Nat. Neurosci., 16: 243–250.
Neuroethology of primate social behavior
Chang SWC, Brent LJN, Adams GK, Klein JT, Pearson JM, Watson KK, and Platt ML (2013) Proc. Natl. Acad. Sci., 110, 10387–10394.
Inhaled oxytocin amplifies both vicarious reinforcement and self reinforcement in rhesus macaques (Macaca mulatta)
Chang SWC, Barter JW, Ebitz RB, Watson KK and Platt ML (2012) Proc. Natl. Acad. Sci., 109, 959–964.
Idiosyncratic and systematic aspects of spatial representations in the macaque parietal cortex
Chang SWC and Snyder LH (2010) Proc. Natl. Acad. Sci., 107, 7951–7956.
Using a compound gain field to compute a reach plan
Chang SWC, Papadimitriou C, and Snyder LH (2009) Neuron, 64, 744–755.