Shaul Yogev

Assistant Professor in Neuroscience

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Departments & Organizations

Faculty Research

Interdepartmental Neuroscience Program

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development: Cell Biology; Development; Imaging (super-resolution); Neurobiology | Neuroscience: Axon Guidance; Development; Molecular/Cellular Neuroscience; Neuroimaging

Biography

Shaul got his BSc and MSc from Paris VII University in France, and his PhD from the Weizmann Institute in Israel, where he studied EGFR signaling with Benny Shilo. As a postdoc with Kang Shen at Stanford he developed imaging tools that enable using forward genetic approaches to study neuronal microtubules and axonal transport in live animals with single cell resolution.

The lab is interested in neuronal cell biology. We want to understand how the architecture of the neuronal cytoskeleton is established and how it supports polarized traffic in order to maintain structures such as synapses, which are found at a large distance from the cell body, over the lifetime of a neuron.

Honors & Recognition

  • Human Frontiers FellowshipHFSP (2011)

  • Haim Holzman memorial prize for academic excellence and scientific accomplishmentsWeizmann Institute (2011)

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Contact Info

Shaul Yogev

Yogev lab website

Rapid reconstruction of neuronal microtubules in vivo

Neuronal microtubules are usually resolved through labor intensive EM reconstructions. We developed a rapid method that uses confocal images (left panel, microtubules labeled along their length with GFP and specifically at one end with RFP) to reconstruct the architecture of the cytoskeleton in live animals (bottom right panel). The top right panel shows a comparison of the fluorescent signal with EM data in the same neuron. This method opens the way to using genetic approaches to understand how microtubules are patterned and how such patterns affect the overlying cargo transport.