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Conformational dynamics of LeuT, a neurotransmitter:sodium symporter, embedded in a nanoscale lipid bilayer (nanodisc), as assessed by hydrogen-deuterium exchange (HDX-MS) kinetics. LeuT is a prokaryotic homolog of the human dopamine and serotonin transporters, currently the primary protein targets of the lab. Individual figures from Adhikary et al, (2017) are overlaid onto an image of the synaptic cleft.