Jaime Grutzendler, MD

Dr. Harry M. Zimmerman and Dr. Nicholas and Viola Spinelli Professor of Neurology and Neuroscience; Director, Center for Experimental Neuroimaging

Departments & Organizations

Neurology: Alzheimer's Disease Research Center (ADRC) | Grutzendler Lab | Memory Disorders & Cognitive Neurology

Interdepartmental Neuroscience Program

Vascular Biology and Therapeutics Program

Yale Cancer Center

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Medicine, Pharmacology, and Physiology | Neuroscience: Neural Disorders

Yale Medicine

Office of Cooperative Research


Dr. Grutzendler obtained his MD at Universidad Javeriana in Bogota, Colombia where he was born and raised. He completed a medical internship in Internal Medicine and a residency in Neurology at Washington University/Barnes-Jewish Hospital in St. Louis. This was followed by a combined clinical and research fellowship in the Alzheimer Disease Research Center and the Department of Neurobiology at Washington University and further neurobiology research training at the Skirball Institute of New York University. Dr. Grutzendler's clinical interests focus on neurodegenerative disorders with special emphasis in dementias such as Alzheimer's disease. He also leads a research laboratory focused on understanding brain function and the cellular basis of neurological diseases. His lab uses advanced microscopy to visualize neurons, endothelium, astrocytes, pericytes, microglia and oligodendrocytes in living animals with the goal of exploring their dynamic behavior and learning how cell-cell interactions develop. He aims to understand how these interactions are disrupted in disease states such as in Alzheimer's disease, stroke and demyelination with the ultimate goal of designing new therapies for these conditions.

Education & Training

MD Universidad Javeriana School of Medicine (1991)
Postdoctoral Fellow Skirball Institute/New York University
Research Fellow Washington University in St. Louis
Clinical Fellow Washington University in St. Louis
Resident Washington Univeristy in St. Louis
Intern Washington University in St. Louis

Honors & Recognition

  • American Society for Clinical InvestigationElected member (2012)

  • McCance Yale Scholar (2011)

  • NIH Director’s Transformative Research Award (2010)

  • Brain and Immunoimaging AwardDana Foundation (2004)

  • New Scholar AwardEllison Foundation (2004)

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Contact Info

Jaime Grutzendler, MD
Patient Care Location
Yale Memory ClinicYale Physicians Building
800 Howard Avenue, Ste Lower Level

New Haven, CT 06519
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Mailing Address
NeurologyPO Box 208018
New Haven, CT 06520-8018

Grutzendler Lab