Contact Info

Gary Rudnick, PhD
Lab Location
Rudnick LabSterling Hall of Medicine, B-Wing
333 Cedar Street, Ste B334

New Haven, CT 06510
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Mailing Address
PharmacologyPO Box 208066
333 Cedar Street

New Haven, CT 06520-8066

Curriculum Vitae

Rudnick Lab

The substrate binding site of LeuT

Substrate binding in LeuT creates a network including Tyr-108, the substrate carboxyl group and a sodium ion bound at the Na1 site. This interaction activates closing of the extracellular pathway, an essential step in transport.