Yale Endocrinology & Metabolism Publications

Recent publications from the section of Endocrinology & Metabolism:

CLEMENS BERGWITZ

Dreimane D, Chen A, Bergwitz C Description of a novel SLC34A3.c.671delT mutation causing hereditary hypophosphatemic rickets with hypercalciuria in two adolescent boys and response to recombinant human growth hormone. Therapeutic Advances in Musculoskeletal Disease 2020 Ther Adv Musculoskelet Dis. 2020 Sep 12;12:1759720X20912862. doi: 10.1177/1759720X20912862. eCollection 2020.

Chande S, Daniel Caballero, Bryan B. Ho, Jonathan Fetene, Juan Serna, Dominik Pesta, Ali Nasiri, Michael Jurczak, Nicholas W. Chavkin, Nati Hernando, Cecilia M. Giachelli, Carsten A. Wagner, Caroline Zeiss, Gerald I. Shulman, Bergwitz C Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival. Sci Rep. 2020 Feb 20;10(1):3069. doi: 10.1038/s41598-020-59430-4.

Bergwitz C, Eussen SRBM, Janssens PLHR, Visser M, Carpenter TO, van Helvoort Different elemental infant formulas show equivalent phosphorus and calcium bioavailability in healthy volunteers. Nutr Res. 2020 Nov 18;85:71-83. doi: 10.1016/j.nutres.2020.11.004.

Iris Hartley, Carole Brennan Miller, George Papadakis, Bergwitz C, Jaydira del Rivero, Jenny Blau, Pablo Florenzano, Jason Berglund, Jing Tassone, Kelly Roszko, Susan Moran, Rachel I. Gafni, Randi Isaacs, Michael T. Collins Targeted FGFR Blockade in the Treatment of Tumor-Induced Osteomalacia 2020 N Engl J Med. 2020 Oct 1;383(14):1387-1389. doi: 10.1056/NEJMc2020399. Epub 2020 Sep 9.

Sampada Chande, Francina Dijk, Jonathan Fetene, Steven Yannicelli, Thomas O. Carpenter, Ardy van Helvoort, Bergwitz C Phosphorus bio-accessibility measured in four infant formulas using in vitro batch digestion translates well into phosphorus bio-availability in mice 2020 Nutr Res. 2021 Jan;85:71-83. doi: 10.1016/j.nutres.2020.11.004. Epub 2020 Nov 18.

Bryan B. Ho, Bergwitz C FGF23 Signalling and Physiology 2020 J Mol Endocrinol. 2020 Dec 1:JME-20-0178.R1. doi: 10.1530/JME-20-0178.

Juan Serna, Bergwitz C Importance of dietary phosphorus for bone metabolism and healthy aging 2020 Nutrients. 2020 Sep 30;12(10):3001. doi: 10.3390/nu12103001.

Bergwitz C, Wysolmerski J Normal Physiology of Bone and Mineral Homeostasis. Cecil Essentials of Medicine, 10th ed. 2021 ISBN978-0-323-72271-1, Chapter 74, pages 729-738

JONATHAN BOGAN

Lyu, K., Zhang, Y., Zhang, D., Kahn, M., ter Horst, K.W., Rodrigues, M.R.S., Hirabara, S.M., Luukkonen, P.K., Lee, S., Bhanot, S., Rinehart, J., Blume, N., Rasch, M.G., Serlie, M.J., Bogan, J.S., Cline, G.W., Samuel, V.T., and Shulman, G.I. Plasma membrane sn-1,2-diacylglycerols induce PKCe-mediated hepatic insulin resistance. Cell Metabolism 2020; 32:654–664. DOI: 10.1016/j.cmet.2020.08.001. PMCID: PMC7544641 Bogan, J.S. Granular detail of b cell structures for insulin secretion. Journal of Cell Biology 2021; 220(2), e202012082. doi: 10.1083/jcb.202012082. PMCID: PMC7802365

Habtemichael, E.N.*, Li, D.T.*, Camporez, J.P., Westergaard, X.O., Sales, C.I., Liu, X., López-Giráldez, F., DeVries, S.G., Li, H., Ruiz, D.M., Wang, K.Y., Sayal, B.S., González Zapata, S., Dann,P., Brown, S.N., Hirabara, S., Vatner, D.F., Goedeke, L., Philbrick, W., Shulman, G.I., and Bogan, J.S. Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake. Nature Metabolism 2021; 3:378–393. doi: 10.1038/s42255-021-00359-x. PMCID: PMC7990718.

KEVAN HEROLD

Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes. Rui J, Deng S, Perdigoto AL, Ponath G, Kursawe R, Lawlor N, Sumida T, Levine-Ritterman M, Stitzel ML, Pitt D, Lu J, Herold KC.Nat Commun. 2021 Aug 20;12(1):5074. Immunotherapy: Building a bridge to a cure for type 1 diabetes. Bluestone JA, Buckner JH, Herold KC.Science. 2021 Jul 30;373(6554):510-516.

Natural mucosal barriers and COVID-19 in children. Pierce CA, Sy S, Galen B, Goldstein DY, Orner E, Keller MJ, Herold KC, Herold BC.JCI Insight. 2021 May 10;6(9):e148694. Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals. Sims EK, Bundy BN, Stier K, Serti E, Lim N, Long SA, Geyer SM, Moran A, Greenbaum CJ, Evans-Molina C, Herold KC; Type 1 Diabetes TrialNet Study Group.Sci Transl Med. 2021 Mar 3;13(583):eabc8980.

Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients. Pierce CA, Preston-Hurlburt P, Dai Y, Aschner CB, Cheshenko N, Galen B, Garforth SJ, Herrera NG, Jangra RK, Morano NC, Orner E, Sy S, Chandran K, Dziura J, Almo SC, Ring A, Keller MJ, Herold KC, Herold BC.Sci Transl Med. 2020 Oct 7;12(564):eabd5487.

ELIZABETH HOLT

Saeed NA, Kelly JR, Deshpande HA, Bhatia AK, Burtness BA, Judson BL, Mehra S,Edwards HA, Yarbrough WG, Peter PR, Holt EH, Decker RH, Husain ZA, Park HS (2020) Adjuvant external beam radiotherapy for surgically resected, nonmetastatic anaplastic thyroid cancer. Head Neck 42:1031-1044.

Jacobs D, Breen CT, Pucar D, Holt EH, Judson BL, Mehra S (2021) Changes in population level and institutional level prescribing habits of radioiodine therapy for papillary thyroid cancer. Thyroid 31:272-279.

Ahmed M, Abi Raad R, Fu L, Holt EH, Adeniran AJ, Cai G. Calcitonin Immunostain Performed on Thin-Prep Slide Enhances Fine Needle Aspiration Diagnosis of Medullary Thyroid Carcinoma. Am J Clin Path. In press. Holt, EH (2020) Endocrine perturbations in critical illness. Chapter 16 in: Surgical Metabolism: The Metabolic Care of the Surgical Patient. Davis, K and Rosenbaum S, Eds. Springer, New York, NY. Holt, EH (2021) editor and author. Goodman’s Basic Medical Endocrinology.

Holt, EH and Inzucchi SE editors (2021) Medical Clinics of North America. Update in Endocrinology. In press.

Holt EH (2021) Current management of thyroid nodules. Chapter in Medical Clinics of North America. Update in Endocrinology. In press.

JANICE HWANG

Food for Thought. Hwang JJ.J Nutr. 2021 Aug 7;151(8):2089-2091. doi: 10.1093/jn/nxab210.PMID: 34195820 Glycemic Variability and CNS Inflammation: Reviewing the Connection. Watt C, Sanchez-Rangel E, Hwang JJ.Nutrients. 2020 Dec 21;12(12):3906. doi: 10.3390/nu12123906.PMID: 33371247

KARL INSOGNA

Burosumab for the Treatment of Tumor-Induced Osteomalacia. Jan de Beur SM, Miller PD, Weber TJ, Peacock M, Insogna K, Kumar R, Rauch F, Luca D, Cimms T, Roberts MS, San Martin J, Carpenter TO.J Bone Miner Res. 2021 Apr;36(4):627-635. doi: 10.1002/jbmr.4233. Epub 2021 Jan 12.PMID: 33338281

New Therapies for Hypophosphatemia-Related to FGF23 Excess. Athonvarangkul D, Insogna KL.Calcif Tissue Int. 2021 Jan;108(1):143-157. doi: 10.1007/s00223-020-00705-3. Epub 2020 Jun 5.PMID: 32504139

An Unanticipated Role for Sphingosine Kinase-2 in Bone and in the Anabolic Effect of Parathyroid Hormone. Walker JM, Yao GQ, Siu E, Zhu M, Sun BH, Simpson C, Insogna KL.Endocrinology. 2021 May 1;162(5):bqab042. doi: 10.1210/endocr/bqab042.PMID: 33640975

Selective deletion of the receptor for CSF1, c-fms, in osteoclasts results in a high bone mass phenotype, smaller osteoclasts in vivo and an impaired response to an anabolic PTH regimen. Zhu M, Sun BH, Nevius E, Kaplan J, Pereira J, Insogna K.PLoS One. 2021 Feb 19;16(2):e0247199. doi: 10.1371/journal.pone.0247199. eCollection 2021.PMID: 33607650

SILVIO INZUCCHI

Ding Q, Qin L, Wojeck B, Inzucchi SE, Ibrahim A, Bravata DM, Strohl KP, Yaggi HK, Zinchuk AV. Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study. Ann Am Thorac Soc. 2021 Jun 29. doi: 10.1513/AnnalsATS.202012-1556OC. Epub ahead of print. PMID: 34185617.

Neeland IJ, Kasai T, Inzucchi SE, Wojeck BS, Yaggi HK, Johansen OE; EMPA-REG OUTCOME Investigators. The Impact of Empagliflozin on Obstructive Sleep Apneaand Cardiovascular and Renal Outcomes: An Exploratory Analysis of the EMPA-REG OUTCOME Trial. Diabetes Care 2020;43:3007-3015. Diabetes Care. 2021 May 20;44(6):e137–8. doi: 10.2337/dci21-0009. Epub ahead of print. PMID: 34016610; PMCID: PMC8247494

Ahmad T, Riello RJ, Inzucchi SE. A Practical Guide for Cardiologists to the Pharmacological Treatment of Patients with Type 2 Diabetes and Cardiovascular Disease. Eur Cardiol. 2021 Mar 30;16:e11. doi: 10.15420/ecr.2020.01.R1. PMID: 33897837; PMCID: PMC8054345.

Kernan WN, Inzucchi SE. Treating Diabetes to Prevent Stroke. Stroke. 2021 May;52(5):1557-1560. doi: 10.1161/STROKEAHA.120.032725. Epub 2021 Apr 20. PMID: 33874746.

McGuire DK, Inzucchi SE, Johansen OE, Rosenstock J, George JT, Marx N. Differences in glycemic control between the treatment arms in cardiovascular outcome trials of type 2 diabetes medications do not explain cardiovascular benefits. J Pharm Policy Pract. 2021 Apr 15;14(1):35. doi: 10.1186/s40545-020-00295-3. PMID: 33858511; PMCID: PMC8048355.

Jhund PS, Ponikowski P, Docherty KF, Gasparyan SB, B.hm M, Chiang CE, Desai AS, Howlett J, Kitakaze M, Petrie MC, Verma S, Bengtsson O, Langkilde AM, Sj.strand M, Inzucchi SE, K.ber L, Kosiborod MN, Martinez FA, Sabatine MS, Solomon SD, McMurray JJV. Dapagliflozin and Recurrent Heart Failure Hospitalizations in Heart Failure With Reduced Ejection Fraction: An Analysis of DAPA-HF. Circulation. 2021 May 18;143(20):1962-1972. doi: 10.1161/CIRCULATIONAHA.121.053659. Epub 2021 Apr 9. PMID: 33832352; PMCID: PMC8126492.Docherty KF, Curtain JP, Anand IS, Bengtsson O, Inzucchi SE, K.ber L, Kosiborod MN, Langkilde AM, Martinez FA, Ponikowski P, Sabatine MS, Schou M, Sj.strand M, Solomon SD, Jhund PS, McMurray JJV; DAPA-HF Investigators and Committees. Effect of dapagliflozin on anaemia in DAPA-HF. Eur J Heart Fail. 2021 Apr;23(4):617-628. doi: 10.1002/ejhf.2132. Epub 2021 Mar 22. PMID: 33615642.

Nassif ME, Windsor SL, Tang F, Husain M, Inzucchi SE, McGuire DK, Pitt B, Scirica BM, Austin B, Fong MW, LaRue SJ, Umpierrez G, Hartupee J, Khariton Y, Malik AO, Ogunniyi MO, Wenger NK, Kosiborod MN. Dapagliflozin effects on lung fluid volumes in patients with heart failure and reduced ejection fraction: Results from the DEFINE-HF trial. Diabetes Obes Metab. 2021 Jun;23(6):1426-1430. doi: 10.1111/dom.14352. Epub 2021 Mar 26. PMID: 33606921.

Berg DD, Jhund PS, Docherty KF, Murphy SA, Verma S, Inzucchi SE, K.ber L, Kosiborod MN, Langkilde AM, Martinez FA, Bengtsson O, Ponikowski P, Sj.strand M, Solomon SD, McMurray JJV, Sabatine MS. Time to Clinical Benefit of Dapagliflozin and Significance of Prior Heart Failure Hospitalization in Patients With Heart Failure With Reduced Ejection Fraction. JAMA Cardiol. 2021 May 1;6(5):499-507. doi: 10.1001/jamacardio.2020.7585. PMID: 33595593; PMCID: PMC7890451.

Butt JH, Nicolau JC, Verma S, Docherty KF, Petrie MC, Inzucchi SE, Schou M, Kosiborod MN, Langkilde AM, Martinez FA, Ponikowski P, Sabatine MS, Sj.strand M, Solomon SD, Bengtsson O, Jhund PS, McMurray JJV, K.ber L. Efficacy and safety of dapagliflozin according to aetiology in heart failure with reduced ejection fraction: insights from the DAPA-HF trial. Eur J Heart Fail. 2021 Apr;23(4):601-613. doi: 10.1002/ejhf.2124. Epub 2021 Mar 10. PMID: 33594755.

Shen L, Kristensen SL, Bengtsson O, B.hm M, de Boer RA, Docherty KF, Inzucchi SE, Katova T, K.ber L, Kosiborod MN, Langkilde AM, Lindholm D, Martinez MFA, O'Meara E, Nicolau JC, Petrie MC, Ponikowski P, Sabatine MS, Schou M, Sj.strand M, Solomon SD, Jhund PS, McMurray JJV. Dapagliflozin in HFrEF Patients Treated With Mineralocorticoid Receptor Antagonists: An Analysis of DAPA-HF. JACC Heart Fail. 2021 Apr;9(4):254-264. doi: 10.1016/j.jchf.2020.11.009. Epub 2021 Feb 3. PMID: 33549554.

Verma S, Mazer CD, Inzucchi SE, Wanner C, Ofstad AP, Johansen OE, Zwiener I, George JT, Butler J, Zinman B. Impact of polyvascular disease with and without co-existent kidney dysfunction on cardiovascular outcomes in diabetes: A post hoc analysis of EMPA-REG OUTCOME. Diabetes Obes Metab. 2021 May;23(5):1173-1181. doi: 10.1111/dom.14326. Epub 2021 Feb 24. PMID: 33502090; PMCID: PMC8247842.

Dewan P, Docherty KF, Bengtsson O, de Boer RA, Desai AS, Drozdz J, Hawkins NM, Inzucchi SE, Kitakaze M, K.ber L, Kosiborod MN, Langkilde AM, Lindholm D, Martinez FA, Merkely B, Petrie MC, Ponikowski P, Sabatine MS, Schou M, Sj.strand M, Solomon SD, Verma S, Jhund PS, McMurray JJV. Effects of dapagliflozin in heart failure with reduced ejection fraction and chronic obstructive pulmonary disease: an analysis of DAPA-HF. Eur J Heart Fail. 2021 Apr;23(4):632-643. doi: 10.1002/ejhf.2083. Epub 2021 Jan 18. PMID: 33368858; PMCID: PMC8247863.

Inzucchi SE, Docherty KF, K.ber L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Solomon SD, Verma S, Bělohl.vek J, B.hm M, Chiang CE, de Boer RA, Diez M, Duk.t A, Ljungman CEA, Bengtsson O, Langkilde AM, Sj.strand M, Jhund PS, McMurray JJV; DAPA-HF Investigators and Committees. Dapagliflozin and the Incidence of Type 2 Diabetes in Patients With Heart Failure and Reduced Ejection Fraction: An Exploratory Analysis From DAPA-HF. Diabetes Care. 2021 Feb;44(2):586-594. doi: 10.2337/dc20-1675. Epub 2020 Dec 18. PMID: 33355302.

Rasouli N, Younes N, Utzschneider KM, Inzucchi SE, Balasubramanyam A, Cherrington AL, Ismail-Beigi F, Cohen RM, Olson DE, DeFronzo RA, Herman WH, Lachin JM, Kahn SE; GRADE Research Group. Association of Baseline Characteristics With Insulin Sensitivity and β-Cell Function in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study Cohort. Diabetes Care. 2021 Feb;44(2):340-349. doi: 10.2337/dc20-1787. Epub 2020 Dec 17. PMID: 33334808; PMCID: PMC7818323.

Ferreira JP, Verma S, Fitchett D, Ofstad AP, Lauer S, Zwiener I, George J, Wanner C, Zinman B, Inzucchi SE. Metabolic syndrome in patients with type 2 diabetes and atherosclerotic cardiovascular disease: a post hoc analyses of the EMPA-REG OUTCOME trial. Cardiovasc Diabetol. 2020 Nov 26;19(1):200. doi: 10.1186/s12933-020-01174-6. PMID: 33243221; PMCID: PMC7694291.

McGuire DK, Zinman B, Inzucchi SE, Wanner C, Fitchett D, Anker SD, Pocock S, Kaspers S, George JT, von Eynatten M, Johansen OE, Jamal W, Mattheus M, Elsasser U, Hantel S, Lund SS. Effects of empagliflozin on first and recurrent clinical events in patients with type 2 diabetes and atherosclerotic cardiovascular disease: a secondary analysis of the EMPA-REG OUTCOME trial. Lancet Diabetes Endocrinol. 2020 Dec;8(12):949-959. doi: 10.1016/S2213-8587(20)30344-2. PMID: 33217335.

Bhatt DL, Szarek M, Pitt B, Cannon CP, Leiter LA, McGuire DK, Lewis JB, Riddle MC, Inzucchi SE, Kosiborod MN, Cherney DZI, Dwyer JP, Scirica BM, Bailey CJ, D.az R, Ray KK, Udell JA, Lopes RD, Lapuerta P, Steg PG; SCORED Investigators. Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease. N Engl J Med. 2021 Jan 14;384(2):129-139. doi: 10.1056/NEJMoa2030186. Epub 2020 Nov 16. PMID: 33200891.

Kraus BJ, Weir MR, Bakris GL, Mattheus M, Cherney DZI, Sattar N, Heerspink HJL, Ritter I, von Eynatten M, Zinman B, Inzucchi SE, Wanner C, Koitka-Weber A. Characterization and implications of the initial estimated glomerular filtration rate 'dip' upon sodium-glucose cotransporter-2 inhibition with empagliflozin in the EMPA-REG OUTCOME trial. Kidney Int. 2021 Mar;99(3):750-762. doi: 10.1016/j.kint.2020.10.031. Epub 2020 Nov 10. PMID: 33181154.

Yeoh SE, Dewan P, Jhund PS, Inzucchi SE, K.ber L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Solomon SD, Bengtsson O, Sj.strand M, Langkilde AM, McMurray JJV; DAPA-HF Investigators and Committees. Patient Characteristics, Clinical Outcomes, and Effect of Dapagliflozin in Relation to Duration of Heart Failure: Is It Ever Too Late to Start a New Therapy? Circ Heart Fail. 2020 Dec;13(12):e007879. doi: 10.1161/CIRCHEARTFAILURE.120.007879. Epub 2020 Nov 9. PMID: 33164553; PMCID: PMC7610491.

Inzucchi SE, Davies MJ, Khunti K, Trivedi P, George JT, Zwiener I, Johansen OE, Sattar N. Empagliflozin treatment effects across categories of baseline HbA1c, body weight and blood pressure as an add-on to metformin in patients with type 2 diabetes. Diabetes Obes Metab. 2021 Feb;23(2):425-433. doi: 10.1111/dom.14234. Epub 2020 Nov 20. PMID: 33084149; PMCID: PMC7839733.

Docherty KF, Jhund PS, Bengtsson O, DeMets DL, Inzucchi SE, K.ber L, Kosiborod MN, Langkilde AM, Martinez FA, Sabatine MS, Sj.strand M, Solomon SD, McMurray JJV; DAPA-HF Investigators and Committees. Effect of Dapagliflozin in DAPA-HF According to Background Glucose-Lowering Therapy. Diabetes Care. 2020 Nov;43(11):2878-2881. doi: 10.2337/dc20-1402. Epub 2020 Sep 2. PMID: 33082245; PMCID: PMC7809714.

Jhund PS, Solomon SD, Docherty KF, Heerspink HJL, Anand IS, B.hm M, Chopra V, de Boer RA, Desai AS, Ge J, Kitakaze M, Merkley B, O'Meara E, Shou M, Tereshchenko S, Verma S, Vinh PN, Inzucchi SE, K.ber L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Bengtsson O, Langkilde AM, Sj.strand M, McMurray JJV. Efficacy of Dapagliflozin on Renal Function and Outcomes in Patients With Heart Failure With Reduced Ejection Fraction: Results of DAPA-HF. Circulation. 2021 Jan 26;143(4):298-309. doi: 10.1161/CIRCULATIONAHA.120.050391. Epub 2020 Oct 12. PMID: 33040613; PMCID: PMC7834909.

Neeland IJ, Eliasson B, Kasai T, Marx N, Zinman B, Inzucchi SE, Wanner C, Zwiener I, Wojeck BS, Yaggi HK, Johansen OE; EMPA-REG OUTCOME Investigators. The Impact of Empagliflozin on Obstructive Sleep Apnea and Cardiovascular and Renal Outcomes: An Exploratory Analysis of the EMPA-REG OUTCOME Trial. Diabetes Care. 2020 Dec;43(12):3007-3015. doi: 10.2337/dc20-1096. Epub 2020 Oct 1. PMID: 33004464; PMCID: PMC7770278.

Siwakoti K, Omay SB, Inzucchi SE. SPONTANEOUS RESOLUTION OF PRIMARY HYPERCORTISOLISM OF CUSHING DISEASE AFTER PITUITARY HEMORRHAGE. AACE Clin CaseRep. 2020 Sep 26;6(1):e23-e29. doi: 10.4158/ACCR-2019-0292. PMID: 32984518; PMCID: PMC7279773.

Flory JH, Hennessy S, Bailey CJ, Inzucchi SE. Response to Comment on Flory et al. Reports of Lactic Acidosis Attributed to Metformin, 2015-2018. Diabetes Care 2020;43:244-246. Diabetes Care. 2020 Oct;43(10):e159. doi: 10.2337/dci20-0036. PMID: 32958623.

Waijer SW, Xie D, Inzucchi SE, Zinman B, Koitka-Weber A, Mattheus M, von Eynatten M, Inker LA, Wanner C, Heerspink HJL. Short-Term Changes in Albuminuria and Risk of Cardiovascular and Renal Outcomes in Type 2 Diabetes Mellitus: A Post Hoc Analysis of the EMPA-REG OUTCOME Trial. J Am Heart Assoc. 2020 Sep 15;9(18):e016976. doi: 10.1161/JAHA.120.016976. Epub 2020 Sep 6. PMID: 32893717; PMCID: PMC7727012.

Docherty KF, Jhund PS, Anand I, Bengtsson O, B.hm M, de Boer RA, DeMets DL, Desai AS, Drozdz J, Howlett J, Inzucchi SE, Johanson P, Katova T, K.ber L, Kosiborod MN, Langkilde AM, Lindholm D, Martinez FA, Merkely B, Nicolau JC, O'Meara E, Ponikowski P, Sabatine MS, Sj.strand M, Solomon SD, Tereshchenko S, Verma S, McMurray JJV. Effect of Dapagliflozin on Outpatient Worsening of Patients With Heart Failure and Reduced Ejection Fraction: A Prespecified Analysis of DAPA-HF. Circulation. 2020 Oct 27;142(17):1623-1632. doi: 10.1161/CIRCULATIONAHA.120.047480. Epub 2020 Sep 4. PMID: 32883108; PMCID: PMC7580857.

Serenelli M, B.hm M, Inzucchi SE, K.ber L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Solomon SD, DeMets DL, Bengtsson O, Sj.strand M, Langkilde AM, Anand IS, Chiang CE, Chopra VK, de Boer RA, Diez M, Duk.t A, Ge J, Howlett JG, Katova T, Kitakaze M, Ljungman CEA, Verma S, Docherty KF, Jhund PS, McMurray JJV. Effect of dapagliflozin according to baseline systolic blood pressure in the Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure trial (DAPA-HF). Eur Heart J. 2020 Sep 21;41(36):3402-3418. doi: 10.1093/eurheartj/ehaa496. PMID: 32820334; PMCID: PMC7550197.

Wanner C, Inzucchi SE, Zinman B, Koitka-Weber A, Mattheus M, George JT, von Eynatten M, Hauske SJ; EMPA-REG OUTCOME Investigators. Consistent effects of empagliflozin on cardiovascular and kidney outcomes irrespective of diabetic kidney disease categories: Insights from the EMPA-REG OUTCOME trial. Diabetes Obes Metab. 2020 Dec;22(12):2335-2347. doi: 10.1111/dom.14158. Epub 2020 Sep 10. PMID: 32744354.

Jackson AM, Dewan P, Anand IS, Bělohl.vek J, Bengtsson O, de Boer RA, B.hm M, Boulton DW, Chopra VK, DeMets DL, Docherty KF, Duk.t A, Greasley PJ, Howlett JG, Inzucchi SE, Katova T, K.ber L, Kosiborod MN, Langkilde AM, Lindholm D, Ljungman CEA, Martinez FA, O'Meara E, Sabatine MS, Sj.strand M, Solomon SD, Tereshchenko S, Verma S, Jhund PS, McMurray JJV. Dapagliflozin and Diuretic Use in Patients With Heart Failure and Reduced Ejection Fraction in DAPA-HF. Circulation. 2020 Sep 15;142(11):1040-1054. doi: 10.1161/CIRCULATIONAHA.120.047077. Epub 2020 Jul 16. Erratum in: Circulation. 2020 Nov 17;142(20):e369. PMID: 32673497; PMCID: PMC7664959.

Solomon SD, Jhund PS, Claggett BL, Dewan P, K.ber L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Inzucchi SE, Desai AS, Bengtsson O, Lindholm D, Sjostrand M, Langkilde AM, McMurray JJV. Effect of Dapagliflozin in Patients With HFrEF Treated With Sacubitril/Valsartan: The DAPA-HF Trial. JACC Heart Fail. 2020 Oct;8(10):811-818. doi: 10.1016/j.jchf.2020.04.008. Epub 2020 Jul 8. PMID: 32653447.

Dewan P, Solomon SD, Jhund PS, Inzucchi SE, K.ber L, Kosiborod MN, Martinez FA, Ponikowski P, DeMets DL, Sabatine MS, Bengtsson O, Sj.strand M, Langkilde AM, Anand IS, Bělohl.vek J, Chopra VK, Duk.t A, Kitakaze M, Merkely B, O'Meara E, Schou M, Vinh PN, McMurray JJV; DAPA-HF Investigators and Committees. Efficacy and safety of sodium-glucose co-transporter 2 inhibition according to left ventricular ejection fraction in DAPA-HF. Eur J Heart Fail. 2020 Jul;22(7):1247-1258. doi: 10.1002/ejhf.1867. Epub 2020 Jun 15. PMID: 32539224.

Inzucchi SE, Khunti K, Fitchett DH, Wanner C, Mattheus M, George JT, Ofstad AP, Zinman B. Cardiovascular Benefit of Empagliflozin Across the Spectrum of Cardiovascular Risk Factor Control in the EMPA-REG OUTCOME Trial. J Clin Endocrinol Metab. 2020 Sep 1;105(9):3025–35. doi: 10.1210/clinem/dgaa321. PMID: 32485734; PMCID: PMC7382052.

Griffin M, Riello R, Rao VS, Ivey-Miranda J, Fleming J, Maulion C, McCallum W, Sarnak M, Collins S, Inzucchi SE, Testani JM. Sodium glucose cotransporter 2 inhibitors as diuretic adjuvants in acute decompensated heart failure: a case series. ESC Heart Fail. 2020 Aug;7(4):1966-1971. doi: 10.1002/ehf2.12759. Epub 2020 May 31. PMID: 32476296; PMCID: PMC7373933.

Griffin M, Rao VS, Ivey-Miranda J, Fleming J, Mahoney D, Maulion C, Suda N, Siwakoti K, Ahmad T, Jacoby D, Riello R, Bellumkonda L, Cox Z, Collins S, Jeon S, Turner JM, Wilson FP, Butler J, Inzucchi SE, Testani JM. Empagliflozin in Heart Failure: Diuretic and Cardiorenal Effects. Circulation. 2020 Sep 15;142(11):1028-1039. doi: 10.1161/CIRCULATIONAHA.120.045691. Epub 2020 May 15. PMID: 32410463; PMCID: PMC7521417.

Verma S, Sharma A, Zinman B, Ofstad AP, Fitchett D, Brueckmann M, Wanner C, Zwiener I, George JT, Inzucchi SE, Butler J, Mazer CD. Empagliflozin reduces the risk of mortality and hospitalization for heart failure across Thrombolysis In Myocardial Infarction Risk Score for Heart Failure in Diabetes categories: Post hoc analysis of the EMPA-REG OUTCOME trial. Diabetes Obes Metab. 2020 Jul;22(7):1141-1150. doi: 10.1111/dom.14015. Epub 2020 Mar 29. PMID: 32227432; PMCID: PMC7318207.

Docherty KF, Jhund PS, Inzucchi SE, K.ber L, Kosiborod MN, Martinez FA, Ponikowski P, DeMets DL, Sabatine MS, Bengtsson O, Sj.strand M, Langkilde AM, Desai AS, Diez M, Howlett JG, Katova T, Ljungman CEA, O'Meara E, Petrie MC, Schou M, Verma S, Vinh PN, Solomon SD, McMurray JJV. Effects of dapagliflozin in DAPA-HF according to background heart failure therapy. Eur Heart J. 2020 Jul 1;41(25):2379-2392. doi: 10.1093/eurheartj/ehaa183. PMID: 32221582; PMCID: PMC7327533.

Verma S, Ji Q, Bhatt DL, Mazer CD, Al-Omran M, Inzucchi SE, Wanner C, Ofstad AP, Zwiener I, George JT, Zinman B, Fitchett D. Association between uric acid levels and cardio-renal outcomes and death in patients with type 2 diabetes: A subanalysis of EMPA-REG OUTCOME. Diabetes Obes Metab. 2020 Jul;22(7):1207-1214. doi: 10.1111/dom.13991. Epub 2020 Mar 28. PMID: 32030863; PMCID: PMC7317186.

ANIA JASTREBOFF

Bini J , Bhatt S, Hillmer A, Gallezot JD, Nabulsi N, Pracitto R, Labaree D, Kapinos M, Ropchan J, Matuskey D, Sherwin R, Jastreboff AM, Carson RE, Cosgrove K, Huang Y. Body Mass Index and Age Effects on Brain 11β-Hydroxysteroid Dehydrogenase Type 1: A Positron Emission Tomography Study. Journal Molecular Imaging and Biology. February 2020. PMID: 32133575.

Angarita GA, Matuskey D, Pittman B, Costeines JL, Potenza MN, Jastreboff AM, Schmidt H, Malison RT. Testing the Effects of the GLP-1 Receptor Agonist Exenatide on Cocaine Self-Administration and Subjective Responses in Humans with Cocaine Use Disorder. Drug and Alcohol Dependence. Epub 2021 Feb 15, 2021 Apr 1. PMID: 332809.

Jebeile H, Cardel M, Kyle T, Jastreboff AM. Addressing Psychosocial Health in the Treatment and Care of Adolescents with Obesity. Obesity. (Accepted March 2021).

Gossman M, Butsch WS, Jastreboff AM. Treating the Chronic Disease of Obesity. Medical Clinics of North America. (Accepted April 2021).

Milner A, Chouairi F, Guha A, Miller P, Pacor J, Fuery M, Jastreboff AM, Ahmad T, Desai N. The Obesity Paradox is not Observed in Patients with HFrEF: a post hoc analysis of the GUIDE-IT trial. Journal of the American Heart Association. (Accepted April 2021).

Asch RRH, Holmes SE, Jastreboff AM, Potenza MMN, Baldassarri SR, Carson RE, Pietrzak RH, Estalaris IE. Lower synaptic density is associated with psychiatric and cognitive alterations in obesity. Neuropsychopharmacology. (Accepted July 2021).

Kidambi S, Batsis JA, Donahoo WT, Jastreboff AM, Kahan S, Saunders KH, Heymsfield SB. Dietary supplements and alternative therapies for obesity: A Perspective from The Obesity Society's Clinical Committee. Obesity (Silver Spring). 2021 Jul 1. doi: 10.1002/oby.23251. PMID: 34212511

Butsch WS, Hajduk A, Cardel MI, Donahoo WT, Kyle TK, Stanford FC, Zeltser LM, Kotz CM, Jastreboff AM. COVID-19 Vaccines are Effective in People with Obesity: A Position Statement from The Obesity Society. Obesity. 01 July 2021. https://doi.org/10.1002/oby.23251

Chouairi F, Milner A, Sen, S, Guha A, Stewart J, Jastreboff AM, Mori M, Clark KA, Miller PE, Fuery MA, Rogers JG; Notarianni A, Jacoby D, Maulion C, Anwer M, Geirsson A, Desai NR, Ahmad T, Mullan CW. Impact of Obesity on Heart Transplantation Outcomes. Journal of the American Heart Association. DOI: 10.1161/JAHA.121.021346. (Accepted August 2021)

ELIZABETH JONAS

Mitochondria: powerhouses of presynaptic plasticity. Subramanian S, Jonas EA. J Physiol. 2021 Mar;599(5):1363-1364. doi: 10.1113/JP281040. Epub 2021 Jan 18.PMID: 33428213

The new role of F₁F_o ATP synthase in mitochondria-mediated neurodegeneration and neuroprotection. Mnatsakanyan N, Jonas EA.Exp Neurol. 2020 Oct;332:113400. doi: 10.1016/j.expneurol.2020.113400. Epub 2020 Jul 10.PMID: 32653453

Oxidative stress battles neuronal Bcl-xL in a fight to the death. Park HA, Broman K, Jonas EA.Neural Regen Res. 2021 Jan;16(1):12-15. doi: 10.4103/1673-5374.286946.PMID: 32788441

Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles. Wu XS, Subramanian S, Zhang Y, Shi B, Xia J, Li T, Guo X, El-Hassar L, Szigeti-Buck K, Henao-Mejia J, Flavell RA, Horvath TL, Jonas EA, Kaczmarek LK, Wu LG.Neuron. 2021 Mar 17;109(6):938-946.e5. doi: 10.1016/j.neuron.2021.01.006. Epub 2021 Jan 27.PMID: 33508244

RICHARD KIBBEY

Lewandowski SL, Cardone RL, Ho T, Foster HR, VanDeusen HR, Alves TC, Poudel C, Capozzi ME, Jahan I, Thomas CJ, Nunemaker CS, MacDonald PE, Campbell JE, Kibbey RG#, and Merrins MJ# “Pyruvate kinase controls signal strength in the insulin secretory pathway” Cell Metabolism 32(2020)751-766 PMC7685238

Abulizi A, Cardone RL, Stark R, Lewandowski SL, Zhao SL, Hillion J, Ma J, Sehgal R, Alves TC, Thomas C, Kung C, Wang B, Seibel S, Andrews Z, Mason GF, Rinehart J, Merrins MJ, and Kibbey RG (2020) “Acceleration of multi-tissue phosphoenolpyruvate cycling improves metabolic homeostasis.” Cell Metabolism 32(2020)736-750. PMC7679013

Song JE, Alves TC, Stutz B, Šestan-Peša M, Kilian N, Jin S, Diano S, Kibbey RG, Horvath TL. Mitochondrial Fission Governed by Drp1 Regulates Exogenous Fatty Acid Usage and Storage in Hela Cells. Metabolites. 2021 May 18;11(5). doi: 10.3390/metabo11050322. PubMed PMID: 34069800; PubMed Central PMCID: PMC8157282.

Zhang H, Xiao Y, Nederlof R, Bakker D, Zhang P, Girardin SE, Hollmann MW, Weber NC, Houten SM, van Weeghel M, Kibbey RG, Zuurbier CJ. NLRX1 Deletion Increases Ischemia-Reperfusion Damage and Activates Glucose Metabolism in Mouse Heart. Front Immunol.2020;11:591815. doi: 10.3389/fimmu.2020.591815. eCollection 2020. PubMed PMID: 33362773; PubMed Central PMCID: PMC7759503.

Chung KM, Singh J, Lawres L, Dorans KJ, Garcia C, Burkhardt DB, Robbins R, Bhutkar A, Cardone R, Zhao X, Babic A, Vayrynen SA, Dias Costa A, Nowak JA, Chang DT, Dunne RF, Hezel AF, Koong AC, Wilhelm JJ, Bellin MD, Nylander V, Gloyn AL, McCarthy MI, Kibbey RG, Krishnaswamy S, Wolpin BM, Jacks T, Fuchs CS, Muzumdar MD. Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma. Cell. 2020 May 14;181(4):832-847.e18. doi: 10.1016/j.cell.2020.03.062. Epub 2020 Apr 17. PubMed PMID: 32304665; PubMed Central PMCID: PMC7266008.

Davis JC, Alves TC, Helman A, Chen JC, Kenty JH, Cardone RL, Liu DR, Kibbey RG, Melton DA. Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis. Cell Rep. 2020 May 12;31(6):107623. doi: 10.1016/j.celrep.2020.107623. PubMed PMID: 32402282; PubMed Central PMCID: PMC7433758.

KASIA LIPSKA

Beyond hemoglobin A1c: a videographic analysis of conversations about quality of life and treatment burden during clinical encounters for diabetes care. Haider S, El Kawkgi O, Clark J, Breslin M, Boehmer KR, Montori V, Lipska K. Endocrine. 2021 Sep;73(3):573-579. doi: 10.1007/s12020-021-02757-3. Epub 2021 Jun 29. PMID: 34189680

Levothyroxine Use in the United States, 2008-2018. Brito JP, Ross JS, El Kawkgi OM, Maraka S, Deng Y, Shah ND, Lipska KJ. JAMA Intern Med. 2021 Jun 21:e212686. doi: 10.1001/jamainternmed.2021.2686. Online ahead of print. PMID: 34152370

Cardiovascular outcomes and rates of fractures and falls among patients with brand-name versus generic L-thyroxine use. Brito JP, Ross JS, Deng Y, Sangaralingham L, Graham DJ, Qiang Y, Wang Z, Yao X, Zhao L,Smallridge RC, Bernet V, Shah ND, Lipska KJ. Endocrine. 2021 Jun 5. doi: 10.1007/s12020-021-02779-x. Online ahead of print. PMID: 34089480

Qualitative analysis of reasons for hospitalization for severe hypoglycemia among older adults with diabetes. Pasciak WE, Berg DN, Cherlin E, Fried T, Lipska KJ. BMC Geriatr. 2021 May 17;21(1):318. doi: 10.1186/s12877-021-02268-w. PMID: 34001014

Contemporary National Patterns of Eligibility and Use of Novel Cardioprotective Antihyperglycemic Agents in Type 2 Diabetes Mellitus. Nargesi AA, Jeyashanmugaraja GP, Desai N, Lipska K, Krumholz H, Khera R.J Am Heart Assoc. 2021 Jul 6;10(13):e021084. doi: 10.1161/JAHA.121.021084. Epub 2021 May 15.PMID: 33998258

The Cost and Safety of Insulin in Older Adults. Huang ES, Lipska KJ. JAMA Intern Med. 2021 May 1;181(5):608-609. doi: 10.1001/jamainternmed.2020.9185. PMID: 33646282

Glucagon use by U.S. adults with type 1 and type 2 diabetes. Kahn PA, Liu S, McCoy R, Gabbay RA, Lipska K. J Diabetes Complications. 2021 May;35(5):107882. doi: 10.1016/j.jdiacomp.2021.107882. Epub 2021 Feb 6. PMID: 33593689

Estimates of insulin needs and dispensation given wastage, alternative glycemic targets, and non-insulin therapies in US populations with type 2 diabetes mellitus: A microsimulation study. Basu S, Shao H, Luo J, Lipska K, Suda KJ, Yudkin JS. J Diabetes Complications. 2021 Apr;35(4):107839. doi: 10.1016/j.jdiacomp.2020.107839. Epub 2020 Dec 31. PMID: 33455873

KITT PETERSEN

R.J. Perry, D. Zhang, M.T. Guerra, A.L. Brill, L. Goedeke, A.R. Nasiri, A. Rabin-Court, Y. Wang, L. Peng, S. Dufour, Y. Zhang, X.M. Zhang, G.M. Butrico, K. Toussaint, Y. Nozaki, G.W. Cline, K.F. Petersen, M.H. Nathanson, B.E. Ehrlich, G.I. Shulman. Glucagon Stimulates

Gluconeogenesis by InsP3R-I Mediated Hepatic Lipolysis. Nature, 579 (7798): 279-283, 2020. PMCID: PMC7101062, PMID: 32132708.

P.K. Luukkonen, S. Dufour, K. Lyu, X.M. Zhang, A. Hakkarainen, T.E. Lehtimäki, G.W. Cline, K.F. Petersen, G.I. Shulman, H. Yki-Järvinen. Effect of a Ketogenic Diet on Hepatic Steatosis and Hepatic Mitochondrial Metabolism in Nonalcoholic Fatty Liver Disease. Proc Natl Acad Sci U S A, 117(13): 7347-7354, 2020. PMCID: PMC7132133, PMID: 32179679.

Y. Nozaki, M.C. Petersen, D. Zhang, D.F. Vatner, R.J. Perry, A. Abulizi, S. Haedersdal, X.M. Zhang, G.M. Butrico, V.T. Samuel, G.F. Mason, G.W. Cline, K.F. Petersen, D.L. Rothman, G.I. Shulman. Metabolic Control Analysis of Hepatic Glycogen Synthesis In Vivo. Proc Natl Acad Sci U S A, 117(14): 8166-8176, 2020. PMCID: PMC714948, PMID: 32188779.

P. Sangwung, K.F. Petersen, G.I. Shulman, J.W. Knowles. Mitochondrial Dysfunction, Insulin Resistance, and Potential Genetic Implications: Potential Role of Alterations in Mitochondrial Function in the Pathogenesis of Insulin Resistance and Type 2 Diabetes. Endocrinology, 161(4):1-10, 2020. PMCID: PMC7341556, PMID: 32060542.

H. Kahleova, K.F. Petersen, G.I. Shulman, J. Alwarith, E. Rembert, A. Tura, M. Hill, R. Holubkov, N.D. Barnard. Effect of a Low-Fat Vegan Diet on Body Weight, Insulin Sensitivity, Postprandial Metabolism, and Intramyocellular and Hepatocellular Lipids in Overweight Adults: A Randomized Clinical Trial. Journal of the American Medical Association, 3(11): e2025454. Published online November 30th, 2020.

J.D. Song, T.C. Alves, D.E. Befroy, R.J. Perry, G. Mason, X.M. Zhang, A. Munk, Y. Zhang, D. Zhang, G.W. Cline, D.L. Rothman, K.F. Petersen, G.I. Shulman. Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference. Cell-Metabolism, 32 (5): 726-735.e5, 2020. PMID: 33035493.

K.F. Petersen, D. L. Rothman, G.I. Shulman. An Alternative Hypothesis for Why Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes. Am J Physiology, Endocrinology and Metabolism, 320 (5): E999-E1000, 2021. PMID: 33843279.

VARMAN SAMUEL

A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance. Lyu K, Zhang Y, Zhang D, Kahn M, Ter Horst KW, Rodrigues MRS, Gaspar RC, Hirabara SM, Luukkonen PK, Lee S, Bhanot S, Rinehart J, Blume N, Rasch MG, Serlie MJ, Bogan JS, Cline GW, Samuel VT, Shulman GI.Cell Metab. 2020 Oct 6;32(4):654-664.e5. doi: 10.1016/j.cmet.2020.08.001. Epub 2020 Sep 2.PMID: 32882164

Membrane-bound sn-1,2-diacylglycerols explain the dissociation of hepatic insulin resistance from hepatic steatosis in MTTP knockout mice. Abulizi A, Vatner DF, Ye Z, Wang Y, Camporez JP, Zhang D, Kahn M, Lyu K, Sirwi A, Cline GW, Hussain MM, Aspichueta P, Samuel VT, Shulman GI.J Lipid Res. 2020 Dec;61(12):1565-1576. doi: 10.1194/jlr.RA119000586. Epub 2020 Sep 9.PMID: 32907986

Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol/PKCε/insulin receptor Thr1160 phosphorylation. Lyu K, Zhang D, Song J, Li X, Perry RJ, Samuel VT, Shulman GI.JCI Insight. 2021 Feb 22;6(4):e139946. doi: 10.1172/jci.insight.139946.PMID: 33411692

GERALD I SHULMAN:

Alkhouri N, Lawitz E, Noureddin M, DeFronzo R, Shulman GI. GS-0976 (Firsocostat): an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of nonalcoholic steatohepatitis (NASH). Expert Opin. Investig. Drugs. 2020; 29(2):135-141. PMCID:PMC7063378, PMID: 31519114.

Han MS, White A, Perry RJ, Camporez JP, Hidalgo J, Shulman GI, Davis RJ. Regulation of adipose tissue inflammation by interleukin 6. Proc Natl Acad Sci U S A. 2020; 117 (6): 2751-2760. PMCID: PMC7022151, PMID: 31980524.

Tarabra E, Nouws J, Vash-Margita A, Nadzam GS, Goldberg R, Van Name M, Pierpont B, Knight JR, Shulman GI, Caprio S. The Omentum of Obese Girls Harbors Small Adipocytes and Browning Transcripts. JCI Insight. 2020; 5(6): e135448. PMCID: PMC7213797, PMID: 32125283.

Perry RJ, Shulman GI. Mechanistic Links between Obesity, Insulin and Cancer. Trends in Cancer. 2020; 6 (2): 75-78. PMCID: PMC7214048, PMID: 32061306.

Chande S, Cabellero D, Ho BB, Fetene J, Serna J, Pesta D, Nasiri A, Jurczak M, Chavkin NW, Hernando N, Giachelli CM, Wagner CA, Zeiss C, Shulman GI, Bergwitz C. Slc20a1/Pit1 and Slc20a2/Pit2 are Essential for Normal Skeletal Myofiber Function and Survival. Scientific Reports. 2020; 10 (1): 3069. PMCID: PMC7033257, PMID: 32080237.

Perry RJ, Zhang D, Guerra MT, Brill AL, Goedeke L, Nasiri AR, Rabin-Court A, Wang Y, Peng L, Dufour S, Zhang Y, Zhang XM, Butrico G, Toussaint K, Nozaki Y, Cline GW, Petersen KF, Nathanson MH, Ehrlich BE, Shulman GI. Glucagon Stimulates Gluconeogenesis by InsP3R-I Mediated Hepatic Lipolysis. Nature. 2020; 579(7798): 279-283. PMCID: PMC7101062, PMID: 32132708.

Sangwung P, Petersen KF, Shulman GI*, Knowles JW*. Mitochondrial Dysfunction, Insulin Resistance and Potential Genetic Implications: Potential Role of Alterations in Mitochondrial Function in the Pathogenesis of Insulin Resistance and Type 2 Diabetes. Endocrinology. 2020; 161(4): bqaa017. PMCID: PMC7341556, PMID: 32060542. *co-senior author

Perry RJ, Lyu K, Rabin-Court A, Dong J, Li X, Yang Y, Qing H, Wang A, Yang X, Shulman GI. Leptin Mediates Postprandial Increases in Body Temperature Through Hypothalamic- Adrenomedullary-Adipose Tissue Crosstalk. Journal of Clinical Investigation. 2020; 130 (4); 2001- 2016. PMCID: PMC7108915, PMID: 32149734.

Luukkonen PK, Dufour S, Lyu K, Zhang XM, Hakkarainen A, Lehtimäki TE, Cline GW, Petersen KF, Shulman GI*, Yki-Järvinen H*. Effect of a Ketogenic Diet on Hepatic Steatosis and Hepatic Mitochondrial Metabolism in Nonalcoholic Fatty Liver Disease. Proc Natl Acad Sci USA. 2020; 117(13): 7347-7354. PMCID: PMC7132133, PMID: 32179679. *co-senior author

Bilet L, Phielix E, Van de Weijer T, Gemmink A, Bosma M, Moonen-Kornips E, Jorgensen JA, Schaart G, Zhang D, Meijer K, Hopman M, Hesselink MKC, Ouwens DM, Shulman GI, Schrauwen-Hinderling VB, Schrauwen P. One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signaling upon lipid infusion: a human study with unilateral limb suspension. Diabetologia. 2020; 63(6): 1211-1222. PMCID: PMC7228997, PMID: 32185462.

Nozaki Y, Petersen MC, Zhang D, Vatner DF, Perry RJ, Abulizi A, Haedersdal S, Zhang XM, Butrico GM, Samuel VT, Mason GF, Cline GW, Petersen KF, Rothman DL, Shulman GI. Metabolic Control Analysis of Hepatic Glycogen Synthesis In Vivo. Proc Natl Acad Sci USA. 2020; 117(14): 8166-8176. PMCID: PMC7149488, PMID: 32188779.

Yang Y, Li X, Luan H, Zhang B, Zhang K, Nam JH, Li Z, Fu M, Munk A, Zhang D, Wang S, Liu Y, Albuquerque JP, Ong Q, Li R, Wang Q, Robert ME, Perry RJ, Chung D, Shulman GI, Yang X. OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance. Proc Natl Acad Sci USA. 2020; 117(28): 16616-16625. PMCID: PMC7368321, PMID: 32601203.

Correa-de-Araujo R, Addison O, Miljkovic I, Goodpaster BH, Bergman BC, Clark RV, Elena JW, Esser KA, Ferrucci L, Harris T, Harris-Love MO, Kritchevsky SB, Lorbergs A, Sherperd JA, Shulman GI, Rosen CJ. Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging. Frontiers in Physiology. 2020; 11:963. PMCID: PMC7438777, PMID: 32903666.

Lyu K, Zhang Y, Zhang D, Kahn M, ter Horst KW, Rodrigues MRS, Gaspar RC, Hirabara SM, Luukkonen PK, Lee S, Bhanot S, Rinehart J, Blume N, Rasch MG, Serlie MJ, Bogan JS, Cline GW, Samuel VT, Shulman GI. A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance. Cell Metabolism. 2020; 32(4): 654-664. PMCID: PMC7544641, PMID: 32882164.

Perry RJ, Shulman GI. Sodium Glucose Cotransporter-2 Inhibitors: Understanding the Mechanisms for Therapeutic Promise and Persisting Risks. Journal of Biological Chemistry. 2020; 295 (42): 14379-14390. PMCID: PMC7573269, PMID: 32796035.

Wang L, Sinnott-Armstrong NA, Wagschal A, Wark AR, Camporez JP, Perry RJ, Ji F, Sohn Y, Oh J, Wu S, Chery J, Moud BN, Saadat A, Dankel SN, Mellgren G, Tallapragada DSP, Strobel SM, Lee MJ, Tewhey R, Sabeti PC, Schaefer A, Petri A, Kauppinen S, Chung RT, Soukas A, Avruch J, Fried SK, Hauner H, Sadreyev RI, Shulman GI, Claussnitzer M, Näär AM. A MicroRNA Linking Human Positive Selection and Metabolic Disorders. Cell. 2020; 183(3): 684-701. PMID: 33058756.

Abulizi A, Vatner DF, Zhang Y, Wang Y, Camporez JP, Zhang D, Kahn M, Lyu K, Sirwi A, ClineGW, Hussain MM, Aspichueta P, Samuel VT, Shulman GI. Membrane-bound sn-1,2-diacylglycerols explain the dissociation of hepatic insulin resistance from hepatic steatosis in MTTP knockout mice. Journal of Lipid Research. 2020; 61(12): 1565-1576. PMCID: PMC7707176, PMID: 32907986.

Song JD, Alves TC, Befroy DE, Perry RJ, Mason G, Zhang XM, Munk A, Zhang Y, Zhang D, Cline GW, Rothman DL, Petersen KF, Shulman GI. Dissociation of Muscle Insulin Resistance from alterations in Mitochondrial Substrate Preference. Cell Metabolism. 2020; 32(5): 726-735.e5. PMID: 33035493.

Kahleova H, Petersen KF, Shulman GI, Alwarith J, Rembert E, Tura A, Hill M, Holubkov R, Barnard ND. Effect of a Low-Fat Vegan Diet on Body Weight, Insulin Sensitivity, Postprandial Metabolism, and Intramyocellular and Hepatocellular Lipids in Overweight Adults: A Randomized Clinical Trial. Journal of the American Medical Association Network Open. 2020; 3(11): e2025454. PMCID: PMC7705596, PMID: 33252690.

He F, Huang Y, Song Z, Zhou HJ, Zhang H, Perry RJ, Shulman GI*, Min W*. Mitophagy-Mediated Adipose Inflammation Contributes to Type 2 Diabetes with Hepatic Insulin Resistance. Journal of Experimental Medicine. 2020; 218(3): e20201416. PMID: 33315085. *corresponding author

Li X, Zhang D, Vatner DF, Goedeke L, Hirabara S, Zhang Y, Perry RJ, Shulman GI. Mechanisms By Which Adiponectin Reverses High-Fat Diet-Induced Insulin Resistance in Mice. PNAS. 2020; 117 (51): 32584–32593. PMCID: PMC7768680, PMID: 33293421.

LaMoia TE, Shulman GI. Cellular and Molecular Mechanisms of Metformin Action. Endocrine Reviews. 1-20. 2021; 42(1): 77–96. PMCID: PMC7846086, PMID: 32897388.

Han MS, Perry RJ, Camporez JP, Sherer PE, Shulman GI, Gao G, Davis RJ. A Feed-Forward Regulatory Loop in Adipose Tissue Promotes Signaling by the Hepatokine FGF21. Genes and Development. 2021; 35(1-2):133-146. PMCID: PMC7778269, PMID: 33334822.

Lyu K, Zhang D, Song J, Li X, Perry RJ, Samuel VT, Shulman GI. Short-Term Overnutrition Induces White Adipose Tissue Insulin Resistance Through sn-1,2-Diacylglycerol – PKCε – Insulin ReceptorT1160 Phosphorylation. JCI Insight. 2021; 6(4):e139946. PMCID: PMC7934919, PMID: 33411692.

Gaspar RC, Pauli JR, Shulman GI, Munoz VR. An Update on Brown Adipose Tissue Biology: A Discussion of Recent Findings. American Journal of Physiology. 2021; 320(3): E488-E495. PMCID: PMC7988785, PMID: 33459179.

Habtemichael EN, Li DT, Camporez JP, Westergaard XO, Sales CI, Liu X, Lopez-Giraldez F, DeVries SG, Li H, Ruiz DM, Wang KY, Bhavesh SS, Zapata SG, Dann P, Brown SN, Hirobara S, Vatner DF, Goedeke L, Philbrick W, Shulman GI, Bogan JS. Insulin-Stimulated Endoproteolytic TUG Cleavage Links Energy Expenditure with Glucose Uptake. Nature Metabolism. 2021; 3(3): 378-393. PMCID: PMC7990718, PMID: 33686286.

Goedeke L, Shulman GI. Therapeutic Potential of Mitochondrial Uncouplers for the Treatment of Metabolic Associated Fatty Liver Disease and NASH. Molecular Metabolism. 2021; (46): 101178. PMCID: PMC8085597. PMID: 33545391.

Loomba R, Friedman SL, Shulman GI. Mechanisms and Disease Consequences of Nonalcoholic Fatty Liver Disease. Cell. 2021; 184 (10): 2537-2564. PMID: 33989548.

Schumann T, König J, Von Loeffelholz C, Vatner DF, Zhang D, Perry RJ, Bernier M, Chami J, Henke C, Kurzbach A, El-Agroudy NN, Willmes DM, Pesta D, De Cabo R, O’Sullivan JF, Simon E, Shulman GI, Hamilton BS, Birkenfeld AL. The Deletion of the Diabetes Candidate Gene Slc16a13 in Mice Attenuates Diet-Induced Ectopic Lipid Accumulation and Insulin Resistance. Communications Biology. 2021; 4 (826): 1-17. PMID: 34211098.

Jiang Z, Zhao M, Voilquin L, Jung Y, Aikio MA , Sahai T, Dou F, Roche A, Carcamo-Orive I, Knowles JW, Wabitsch M , Appel EA, Maikawa CL , Camporez JP, Shulman GI, Tsai L, Rosen ED, Gardner CD, Spiegelman BM, Svensson KJ. Isthmin-1 is an Adipokine that Promotes Glucose Uptake and Improves Glucose Tolerance and Hepatic Steatosis. Cell Metabolism. (2021; published online ahead of print.)

DANIEL VATNER

Mechanisms by which adiponectin reverses high fat diet-induced insulin resistance in mice. Li X, Zhang D, Vatner DF, Goedeke L, Hirabara SM, Zhang Y, Perry RJ, Shulman GI.Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32584-32593. doi: 10.1073/pnas.1922169117. Epub 2020 Dec 8.PMID: 33293421

Membrane-bound sn-1,2-diacylglycerols explain the dissociation of hepatic insulin resistance from hepatic steatosis in MTTP knockout mice. Abulizi A, Vatner DF, Ye Z, Wang Y, Camporez JP, Zhang D, Kahn M, Lyu K, Sirwi A, Cline GW, Hussain MM, Aspichueta P, Samuel VT, Shulman GI.J Lipid Res. 2020 Dec;61(12):1565-1576. doi: 10.1194/jlr.RA119000586. Epub 2020 Sep 9.PMID: 32907986

Hepatic Insulin Resistance Is Not Pathway Selective in Humans With Nonalcoholic Fatty Liver Disease. Ter Horst KW, Vatner DF, Zhang D, Cline GW, Ackermans MT, Nederveen AJ, Verheij J, Demirkiran A, van Wagensveld BA, Dallinga-Thie GM, Nieuwdorp M, Romijn JA, Shulman GI, Serlie MJ.Diabetes Care. 2021 Feb;44(2):489-498. doi: 10.2337/dc20-1644. Epub 2020 Dec 8.PMID: 33293347

Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake. Habtemichael EN, Li DT, Camporez JP, Westergaard XO, Sales CI, Liu X, López-Giráldez F, DeVries SG, Li H, Ruiz DM, Wang KY, Sayal BS, González Zapata S, Dann P, Brown SN, Hirabara S, Vatner DF, Goedeke L, Philbrick W, Shulman GI, Bogan JS.Nat Metab. 2021 Mar;3(3):378-393. doi: 10.1038/s42255-021-00359-x. Epub 2021 Mar 8.PMID: 33686286

Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance. Schumann T, König J, von Loeffelholz C, Vatner DF, Zhang D, Perry RJ, Bernier M, Chami J, Henke C, Kurzbach A, El-Agroudy NN, Willmes DM, Pesta D, de Cabo R, O Sullivan JF, Simon E, Shulman GI, Hamilton BS, Birkenfeld AL.Commun Biol. 2021 Jul 1;4(1):826. doi: 10.1038/s42003-021-02279-8.PMID: 34211098

LI WEN

Huang J, Pearson JA, Hu Y, Sha S, Xing Y, Huang G, Li X, Hu F, Xie Z, Yang X, Luo S, Chao C, Wong FS, Zhou Z, Wen L. Gut microbial metabolites alter IgA immunity in type 1 diabetes. JCI Insight. 2020, 5(10):e135718; PubMed PMID: 32298241

Huang J, Huang G, Li X, Hu F, Xie Z, Xiao Y, Lou S, Chao C, Guo K, Wong FS, Zhou Z, Wen L. Altered systemic and intestinal IgA immune responses in individuals with type 1 diabetes. J Clin Endo Metab. 2020 105(12):e4616-25, PubMed PMID: 32860693

Pearson JA, Li YY, Majewska-Szczepanik M, Guo J, Zhang L, Liu Y, Wong FS and Wen L. Insulin-reactive T cells convert diabetogenic insulin-reactive B cells into tolerogenic cells by reducing germinal center T:B cell interactions in NOD mice. Front Immunol. 2020 11:585886; PubMed PMID: 33262765

Thayer TC, Davies J, Pearson JA, Hanna SJ, Wen L and Wong FS. Differentiating MHC-dependent and –independent mechanisms of lymph node stromal cell regulation of proinsulin-specific CD8+ T cells in type 1 diabetes. Diabetes 2021 70(2):529-37, PubMed PMID: 33122391

Boldison J, Da Rosa LC, Davies J, Wen L, Wong FS. Dendritic cells license regulatory B cells to produce IL-10 and mediate suppression of antigen-specific CD8 T cells. Cell Mol Immunol 2020 Aug; 17:8430855 PMID: 31728048

Sha S, Pearson JA, Peng J, Huang J, Zhu Jm Zhao H, Wong FS, Chen L & Wen L. TLR9- deficiency in B cells promotes immune tolerance via IL-10 in an autoimmune diabetes mouse model. Diabetes 2021 70(2):504-515; PubMed PMID: 33154070

Huang J, Peng J, Pearson JA, Ethimiou G, Hu Y, Tai N, Sha S, Xing Y, Zhang L, Zhou Z, Wong FS, Wen L. Toll-like receptor 7 deficiency protects against type 1 diabetes by modulating B cell differentiation and function. Cell Mol Immunol 2021, 18(2):328-338; PubMed PMID: 33432061

Huang J, Tan Q, Tai N, Pearson JA, Li YY, Chao C, Zhang L, Peng J, Xing YP, Zhang LY, Hu YJ, Zhou ZG, Wong FS and Wen L. IL-10 deficiency accelerates type 1 diabetes development via modulation of innate and adaptive immune cells and gut microbiota in BDC2.5 NOD mice. Front Immunology. 2021. 702955; PMID: 34394099

Chen D, Thayer TC, Wen L, Wong FS. Mouse models of autoimmune diabetes: the nonobese diabetic (NOD) mouse. Methods Mol Biol. 2020;2128:87-92. PMID: 32180187.

Wong FS, Wen L A predictive CD8+ T cells phenotype for T1DM progression. Nat Rev Endocrinol. 2020 16:198-199, PMID: 32051538

Pearson JA, Wong FS, Wen L. Crosstalk between circadian rhythms and the microbiota. Immunol. 2020 161:278-290, PMID: 33090484

Huang J, Pearson JA, Wong FS, Wen L, Zhou ZG. Innate immunity in latent autoimmune diabetes in adults. Diabetes Metab Res Rev. 2021 June5; e3480, PMID: 34156143

Pearson JA, Wong FS, Wen L. Inflammasomes and type 1 diabetes. Front Immunol. 2021, 12:686956; PMID: 34177937

JOHN WYSOLMERSKI

Jeong J, Kadegowda AKG, Meyer TJ, Jenkins LM, Dinan JC, Wysolmerski JJ, Weigert R, Mather IH. The butryrophilin 1a1 knockout moser revisited: Ablation of Btn1a1 leads to concurrent cell death and renewal in the mammary epithelium during lactation. FASEB BioAdvances 2021; May 15, 1-27, DOI: 10.1096/fba.2021-00059.

Grinman D, Athonvarungkul D, Wysolmerski JJ, Jeong J. Calcium metabolism and breast cancer: echoes of lactation? Curr Opin Endocr Metab Res 2020 Dec;15:63-70. doi: 10.1016/j.coemr.2020.11.006.Epub 2020 Nov 21.

Bergwitz C and Wysolmerski JJ. Normal Physiology of Bone and Mineral Homeostasis. Chapter 70 in Cecil Essetials of Medicine, 10^th Edition. In Press.

Yale’s Section of Endocrinology & Metabolism works to improve the health of individuals with endocrine and metabolic diseases by advancing scientific knowledge; applying new information to patient care; and training the next generation of physicians and scientists to become leaders in the field. To learn more about their work, visit Endocrinology & Metabolism.