Valentina Greco, PhD

Carolyn Walch Slayman Professor of Genetics

Research Interests

Cell Biology; Dermatology; Genetics; Neoplasms by Histologic Type; Regeneration; Stem Cells; Stem Cell Niche

Research Organizations

Cell Biology

Rheumatic Diseases Research Core

Status of Women in Medicine Committee (SWIM)

Yale Cancer Center: Signal Transduction

Yale Stem Cell Center

Office of Cooperative Research

Research Summary

Stem cells and the microenvironment in which they reside - the so called niche - are central for the development and regeneration of all our organs, and their deregulation leads to a disease state. Despite the key relevance of stem cell niches and their conserved features, the dynamic interactions between stem cells and the niche are still not well understood.

The aim of my lab is to understand how stem cells and the niche contribute to tissue regeneration and what goes awry during disease states such as cancer using the murine skin hair follicle as a model system. The major challenge in studying these questions is the lack of accessibility to stem cell niches and consequently the inability to visualize the same stem cells over time to determine their specific behavior and long-term fate.

My laboratory has established the ability to study cellular mechanisms, in real-time, within an intact stem cell niche during physiological hair follicle regeneration in live mice. My lab integrates cell biology, genetics, genomics and two-photon imaging of live mice to understand 1) the functional role that stem cell niche components exert during hair follicle regeneration, 2) the signaling mechanisms that control hair follicle stem cell behaviors and 3) how basic mechanisms of hair follicle regeneration are hijacked during disease such as skin cancer.

Specialized Terms: Organ regeneration in vertebrate systems; Stem cells; Stem cell niche organization; Cancer

Selected Publications

Full List of PubMed Publications

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