Qin Yan, PhD

Associate Professor of Pathology; Director, Epigenetics Program

Research Interests

Gene Expression Regulation; Neoplasm Metastasis; Neoplasms; Stem Cells; Neoplastic Stem Cells; Histone Demethylases; Epigenomics

Research Organizations

Pathology: Pathology Research | Yan Lab

Discovery to Cure Internship

Yale Cancer Center: Genomics, Genetics, and Epigenetics

Yale Stem Cell Center

Office of Cooperative Research

Research Summary

Epigenetic aberrations often lead to cancer and other human diseases. The long-term goal of our laboratory is to elucidate the roles of epigenetic regulation in cancer and to translate our findings to the clinic. In particular, we focus on the epigenetic regulators of cancer metastasis, antitumor immune response and resistance to anticancer drugs. Among these epigenetic regulators, the KDM5/JARID1 histone demethylases are demethylases for tri- methylated lysine 4 in histone H3 (H3K4me3), the epigenetic mark for transcriptionally active chromatin. Using KDM5A/B knockout mouse models, we showed that loss of KDM5A or KDM5B inhibits tumorigenesis in several genetically engineered mouse models. We are currently studying how these epigenetic regulators contribute to cancer initiation and progression using biochemical, molecular biological, cell biological and mouse genetic approaches. As these epigenetic regulators are potential drug targets, we are developing inhibitors against these regulators for cancer treatment.

Specialized Terms: Epigenetics; Gene regulation; Cancer biology

Selected Publications

Full List of PubMed Publications

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