WEBVTT

NOTE duration: "00:03:24.245"


NOTE Confidence: 0.9938026

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We think about inflammation as

NOTE Confidence: 0.9938026

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sort of a pathological reaction

NOTE Confidence: 0.9938026

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to an invader

NOTE Confidence: 0.92333984

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or an injury

NOTE Confidence: 0.94177246

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and actually exercise induced inflammatory

NOTE Confidence: 0.94177246

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responses are what we call

NOTE Confidence: 0.94177246

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physiological inflammation.

NOTE Confidence: 0.97320557

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And they're essentially this

NOTE Confidence: 0.99033606

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symphony of cells responding to

NOTE Confidence: 0.99033606

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a perturbation as a reaction

NOTE Confidence: 0.99033606

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to a stress imposed by

NOTE Confidence: 0.99033606

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exercise.

NOTE Confidence: 0.95738

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And we know already that

NOTE Confidence: 0.95738

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exercise stimulates the immune in

NOTE Confidence: 0.95738

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young and old animals, but

NOTE Confidence: 0.95738

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it seems that there's a

NOTE Confidence: 0.95738

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bit of an intolerance of

NOTE Confidence: 0.95738

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the immune system to exercise

NOTE Confidence: 0.95738

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in old animals and also

NOTE Confidence: 0.95738

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in in old people. So

NOTE Confidence: 0.95738

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we're trying to rejuvenate the

NOTE Confidence: 0.95738

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immune system to hopefully give

NOTE Confidence: 0.95738

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a more youthful response to

NOTE Confidence: 0.95738

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exercise to improve muscle function

NOTE Confidence: 0.95738

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and then therefore,

NOTE Confidence: 0.9526774

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reverse frailty and, improve, health

NOTE Confidence: 0.9526774

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span.

NOTE Confidence: 0.9001709

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We are interested in exercise

NOTE Confidence: 0.9001709

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and aging as two contexts,

NOTE Confidence: 0.9908114

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but we really wanna understand

NOTE Confidence: 0.9908114

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how the immune system is

NOTE Confidence: 0.9908114

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recognizing

NOTE Confidence: 0.9545352

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stress in the form of

NOTE Confidence: 0.9545352

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exercise or associated with age.

NOTE Confidence: 0.9545352

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What are the things that

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they see and then what

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did they do in reaction

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to the stress to help

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restore the tissue and the

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organism to, its homeostatic set

NOTE Confidence: 0.9545352

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point where it's it's steady

NOTE Confidence: 0.9545352

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state. And so we take

NOTE Confidence: 0.9545352

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a a combination of approaches

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to understand this and the

NOTE Confidence: 0.9545352

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ultimate goal is to translate

NOTE Confidence: 0.9545352

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this into therapies that are

NOTE Confidence: 0.9545352

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inspired by the the natural

NOTE Confidence: 0.9545352

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processes induced by exercise.

NOTE Confidence: 0.9630221

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We look at, metabolic mechanisms,

NOTE Confidence: 0.9630221

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so how metabolic stress is

NOTE Confidence: 0.9630221

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induced by exercise,

NOTE Confidence: 0.9535675

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mechanical stress that might be

NOTE Confidence: 0.9535675

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due to changes in tissue

NOTE Confidence: 0.9535675

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stiffness, which requires some bioengineering

NOTE Confidence: 0.9535675

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expertise.

NOTE Confidence: 0.97271544

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So we pull, techniques from

NOTE Confidence: 0.97271544

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all these disciplines, metabolic biology,

NOTE Confidence: 0.97271544

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immunology,

NOTE Confidence: 0.8666992

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bioengineering,

NOTE Confidence: 0.98235375

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and we sort of span

NOTE Confidence: 0.98235375

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different scales. We look at

NOTE Confidence: 0.98235375

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the level of the animal

NOTE Confidence: 0.98235375

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to the tissue level, which

NOTE Confidence: 0.98235375

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for us is usually skeletal

NOTE Confidence: 0.98235375

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muscle, but we also look

NOTE Confidence: 0.98235375

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at adipose and and liver,

NOTE Confidence: 0.98235375

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all the way down to

NOTE Confidence: 0.98235375

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cells and molecules.

NOTE Confidence: 0.9692383

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And so we might use,

NOTE Confidence: 0.96828204

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flow cytometry or single cell

NOTE Confidence: 0.96828204

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sequencing to look at cells

NOTE Confidence: 0.96828204

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and molecules.

NOTE Confidence: 0.9963989

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And we also have,

NOTE Confidence: 0.98195744

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exercise protocols that we subject

NOTE Confidence: 0.98195744

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our animals to to measure

NOTE Confidence: 0.98195744

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their performance. So we use

NOTE Confidence: 0.98195744

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a wide array of techniques

NOTE Confidence: 0.98195744

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from different disciplines to help

NOTE Confidence: 0.98195744

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us answer this very complex

NOTE Confidence: 0.98195744

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question of what induces physiological

NOTE Confidence: 0.98195744

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inflammation and what is it

NOTE Confidence: 0.98195744

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doing.

NOTE Confidence: 0.96691895

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We've seen that immunology has

NOTE Confidence: 0.96691895

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sort of transformed

NOTE Confidence: 0.9580078

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cancer research

NOTE Confidence: 0.9071452

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And in particular, immunotherapy,

NOTE Confidence: 0.988227

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leveraging the immune system as

NOTE Confidence: 0.988227

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a tool to combat,

NOTE Confidence: 0.97526044

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afflictions like cancer has been

NOTE Confidence: 0.97526044

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transformative.

NOTE Confidence: 0.9909668

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I think that the same

NOTE Confidence: 0.9909668

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potential exists for exercise biology

NOTE Confidence: 0.9909668

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and aging biology.

NOTE Confidence: 0.95748466

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So we like to say

NOTE Confidence: 0.95748466

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that we are trying to

NOTE Confidence: 0.95748466

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discover exercise inspired immunotherapy

NOTE Confidence: 0.92631024

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that can combat age related

NOTE Confidence: 0.92631024

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dysfunction and also bolster responses

NOTE Confidence: 0.92631024

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to exercise because exercise is

NOTE Confidence: 0.92631024

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our best medicine,

NOTE Confidence: 0.90760714

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to counteract aging and also

NOTE Confidence: 0.90760714

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in other context, disease states

NOTE Confidence: 0.90760714

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as well. We know exercise

NOTE Confidence: 0.90760714

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is beneficial.

NOTE Confidence: 0.9658927

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And so I'm really motivated

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in using the repertoire of

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skills that I've developed as

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a scientist to understand this

NOTE Confidence: 0.9658927

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tug of war between the

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yin and yang of the

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deterioration and the building up

NOTE Confidence: 0.9658927

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that, agent exercise cause so

NOTE Confidence: 0.9658927

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that we can sort of

NOTE Confidence: 0.9658927

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skew the balance, you know,

NOTE Confidence: 0.9658927

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in favor of resilience.

NOTE Confidence: 0.9728868

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And the lab has already

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uncovered some interesting mechanisms that

NOTE Confidence: 0.9728868

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we can use to to

NOTE Confidence: 0.9728868

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push this balance. And so

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that's even more motivating that

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I think that there are

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tractable mechanisms that we can

NOTE Confidence: 0.9728868

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target

NOTE Confidence: 0.9663696

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that can have an effect

NOTE Confidence: 0.9663696

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on this balance.