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Structural Analysis of Immune System Receptors and Effectors

There is a growing interest in using structural approaches to understand the function of key molecules of the immune response. For example, a major effort is devoted towards understanding how the Toll-like receptors, despite their similarity in extracellular-ligand recognition regions, are able to specifically recognize such a wide variety of pathogen associated molecular patterns (PAMPS). Another effort is aimed at understanding the mechanism of APOBEC enzymes in controlling viruses such as HIV.