Genetics Department Seminar Series: "Mechanisms of Gastrulation: From Zebrafish to Human"

Gastrulation is a fundamental morphogenetic process during animal embryogenesis that generates the mesoderm, endoderm, and ectoderm germ layers and, through coordination of cell proliferation, migration and rearrangement, shapes them into a blueprint of the body plan. I will discuss forward and reverse genetic approaches we pursue in zebrafish and human embryonic stem cells 2D micropatterned gastruloid platform to define the genetic hierarchies underlying the formation and shaping of the germ layers.