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Shervin (Seyedtaghi) Takyar, MD, PhD

Associate Professor Term

Contact Information

Shervin (Seyedtaghi) Takyar, MD, PhD

Patient Care Locations

Mailing Address

  • PO Box 208057, 300 Cedar Street

    New Haven, CT, 06520-8057

    United States

Biography

I did my PhD in microbiology and molecular biology in The University of Queensland, Australia. During my PhD I worked and published on a variety of projects including developing a new lentiviral vector based on JDV (Jembrana Disease Virus), translational regulation in HCV by small RNA-binding molecules and the viral core protein, and RNA-protein interactions in positive strand RNA viruses. During this time I was also involved in cloning the Australian isolate of HCV with Dr Eric Gowans. My findings in these projects were published in a variety of journal including PNAS, Hepatology, and Journal of Molecular Biology.My next stop was a postdoctoral fellowship with Prof. Harry Noller at the RNA Center in UCSC where I delved deeper into the RNA world and studied the helicase activity of the ribosome during translation. Our work was well received and published in Cell.

I started my Internal Medicine residency at the State University of New York (SUNY) at Buffalo in 2003. During the last year of my residency I took part in a research project led by Dr Sands on the role of TIMP-1 in reactive airway disease. Our work was published in Clinical Immunology. I was then recruited to the Pulmonary Critical Care Fellowship at Yale in 2007, and worked with Dr J Elias to set up a platform for analyzing the role of microRNAs in the lung disease using the transgenic models that have been developed in his lab. I started this work on an inducible, lung-specific, VEGF transgenic model and within the first year of the project found a microRNA that was regulated by VEGF and mediated the effects of this cytokine in the lung. Based on these findings we filed a patent on the diagnsostic and therapeutic use of miR-1 in lung disease. I received a K99/R00 award in the third year of my clinical fellowship for my work on this project. I was directly recruited as a tenure-track Assistant Professor in the Yale Pulmonary, Critical Care and Sleep Medicine Section at the end of my fellowship.

Since starting my tenure track position in 2010 I have been awarded the AAP (American Association of Physicians) Junior Investigator Award for my work on microRNAs in the lung and have given invited presentations at various international conferences. Our work on the role of VEGF-miR-1 axis in lung Th2 inflammation was published in Journal of Experimental Medicine. I successfully transitioned to the R00 (Independent investigator) phase of my NIH grant in 2013. I have recruited and worked with two postdoctoral fellows and three Associate Research Scientists over the last three years. My research currently focuses on the role of vascular non-coding RNAs in Th2 inflammation, lung injury and cancer.

Education & Training

  • PhD
    University of Queensland (2002)
  • MD
    Iran University of Medical Sciences (1995)
  • Fellow
    Yale University School of Medicine
  • Resident
    State University of New York - Buffalo
  • Fellow
    University of California at San Cruz
  • PG1
    University of Queensland
  • Board Certification
    AB of Internal Medicine, Pulmonary Disease (2012)

Activities

  • RNA Modification Enzymes Control Non Small Cell Tumor Growth Through Regulation of the Angiogenic Response
    Washington, United States 2017
  • RNA Modification Enzymes Control Non Small Cell Tumor Growth Through Regulation of the Angiogenic Response
    Washington, United States 2017
  • Cell-specific MicroRNA-driven Pathway Controls the Recruitment of Eosinophils in Type 2 Inflammation
    Washington, United States 2017
  • Cell-specific MicroRNA-driven Pathway Controls the Recruitment of Eosinophils in Type 2 Inflammation
    Washington, United States 2017
  • MicroRNA-1 Levels Determine the Type of Inflammatory Remodeling in Chronic Rhinosinusitis
    Washington, United States 2017
  • From inflammation to cancer: trials and tribulations of an endothelial microRNA
    Denver, United States 2016
  • Non-Small Cell Lung Cancer (NSCLC) Tumor Progression is Inhibited in an Inducible Vascular-Specific MicroRNA-1 (miR-1) Transgenic Model
    San Francisco, United States 2016
  • VEGF Induces Lung Angiogenesis Through "Tailing and Trimming" of MicroRNAs and Production of 3'-Modified IsomiRs
    San Francisco, United States 2016
  • MiR-1 Expression in the Vicinity of Non-Small Cell Cancer Correlates with Patient Survival
    San Francisco, United States 2016
  • Lung Endothelial miR-1 Recruits Angiopoietin-2 to RNA Induced Silencing Complex (RISC) and Protects Lungs against Oxidant Injury through an Angiocrine Mechanism
    Andover, United States 2015
  • An Intrinsic Endothelial miR-1 Degradation Pathway Regulates Non-Small Cell Lung Cancer (NSCLC) Tumor Vascularity and Progression
    Keystone, United States 2015
  • Endothelial microRNA-1 Protects against Lung Hyperoxic Injury and Downregulates Ang2 Expression
    Denver, United States 2015
  • An intrinsic endothelial miR-1 pathway controls vascular activation in asthma and lung cancer
    Bethesda, United States 2014
  • An Endothelial microRNA Circuit Controls Vascular Activation in Asthma and Lung Cancer
    Rahway, United States 2014
  • An Endothelial-specific VEGF Receptor 2-miR-1-Mpl Circuit Controls the Severity of Lung Th2 Inflammation
    San Diego, United States 2014
  • Endothelial miR-1 is Downregulated in Lung Cancer Models and Controls the Progression of Lung Tumors through Inhibition of VEGF Signaling
    Philadelphia, United States 2013
  • MiR-1 Inhibits adaptive Th2 Inflammation in the Lung via a VEGF/Mpl Axis
    Waltham, United States 2011
  • Mechanism and Control of Posttranscriptional Gene Expression
    New York, United States 2005
  • mRNA helicase activity of the ribosome
    New York, United States 2005
  • A ribosomal helicase: unwinding mRNA during ribosomal translocation
    San Francisco, United States 2003
  • Cyanocobalamin-HCV IRES interaction: a molecular model for translational regulation
    Stanford, United States 2001

Honors & Recognition

AwardAwarding OrganizationDate
Abstract ScholarshipAmerican Thoracic Society, Respiratory Cell Molecular Biology Assembly2016
Abstract ScholarshipAmerican Thoracic Society, Thoracic Oncology Assembly2015
Abstract ScholarshipAmerican Thoracic Society, Allergy, Immunology and Inflammation Assembly2014
Junior Investigator AwardAAP/ASCI (American Association of Physicians/ American Society of Clinical investigators)2011
RNA Society Fellowship of BBSRCBitechnology and Biological Sciences Research Council2005
University of Queensland Graduate School AwardsUniversity of Queensland2000
University of Queensland Postgraduate Research ScholarshipUniversity of Queensland1999

Professional Service

OrganizationRoleDate
FASEBReviewer2017 - Present
European Respiratory JournalReviewer2017 - Present
American Thoracic Society International Conference, Poster Discussion Session: “MicroRNAs, RNAseq, LncRNA: Biology and Function"Chair2016
American Journal of Physiology / Lung Cellular and Molecular PhysiologyReviewer2016 - Present
American Journal of Respiratory and Critical Care MedicineReviewer2016 - Present
Journal of Cell BiologyReviewer2015 - Present
Molecular MedicineReviewer2015 - Present
Pulmonary Medicine and Respiratory ResearchEditor2015 - Present
Neuroscience LettersReviewer2014
Journal of Clinical ImmunologyReviewer2013

Departments & Organizations