Kallol Gupta, PhD

Initially trained as a chemist, I was introduced to the world of biology through the aquatic route, where my goal was to uncover the molecular diversity present in the venoms of marine cone snails and understand how it impairs the functions of key ion channels and transporters. This introduced and made me fascinated about the world of membrane proteins.

I subsequently moved to the University of Oxford as a Fellow of the 1851 Royal Commission. Here, my research led to a transformative advancement that enabled top-down mass spectrometric (MS) analysis of membrane protein-lipid complexes. Application of this approach yielded atomistic understanding of how lipids act as a key signaling molecule to regulate structural and functional organization of membrane proteins.

In the Fall of 2018, I crossed the pond to start my own lab in Yale. Combining native mass spectrometry with an array of orthogonal experimental and computational approaches, our lab is focused on developing platforms that enable quantitative analysis of macromolecular protein complexes directly from the cellular environment. Applying this, the lab aims to understand how spatiotemporal organization of membrane protein interactomes regulate cellular physiology.