Association of TGF-β expression with intratumoral infiltration of cytotoxic T lymphocytes in patients with microsatellite-stable colorectal cancer.
Mehrvarz Sarshekeh A, Katkhuda R, Verma A, Advani S, Overman M, Maru D, Kopetz S. Association of TGF-β expression with intratumoral infiltration of cytotoxic T lymphocytes in patients with microsatellite-stable colorectal cancer. Journal Of Clinical Oncology 2019, 37: 3577-3577. DOI: 10.1200/jco.2019.37.15_suppl.3577.Peer-Reviewed Original ResearchConsensus molecular subtype 4Colorectal cancerMSS colorectal cancerEMT gene signatureCTL infiltrationIntratumoral infiltrationImmune cellsTumor microenvironmentGene signatureMicrosatellite stable colorectal cancerAssociation of TGFInfiltration of CTLsHigh relapse rateRank correlation analysisCytotoxic T lymphocytesTGF-β expressionTGF-β activationExpression levelsTGF-β pathwayParaffin-embedded samplesRelapse rateImmunotherapy responseMacrophage infiltrationPoor prognosisTumor infiltration