2016
Post-traumatic Stress Disorder and Cardiovascular Disease
Burg MM, Soufer R. Post-traumatic Stress Disorder and Cardiovascular Disease. Current Cardiology Reports 2016, 18: 94. PMID: 27566327, DOI: 10.1007/s11886-016-0770-5.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderCardiovascular diseaseStress disorderIncident hypertension riskIncident cardiovascular diseaseAcute cardiac eventsEmergency department environmentCardiac eventsCardiovascular mortalityEarly recurrenceMilitary veteran sampleHypertension riskClinical pathwayPatient experiencePTSD treatmentPTSD onsetTrauma exposureVeteran sampleAutomobile accidentsDepartment environmentMortalityDiseaseRiskTraumaDisorders
2014
Confluence of Depression and Acute Psychological Stress Among Patients With Stable Coronary Heart Disease: Effects on Myocardial Perfusion
Burg MM, Meadows J, Shimbo D, Davidson KW, Schwartz JE, Soufer R. Confluence of Depression and Acute Psychological Stress Among Patients With Stable Coronary Heart Disease: Effects on Myocardial Perfusion. Journal Of The American Heart Association 2014, 3: e000898. PMID: 25359402, PMCID: PMC4338683, DOI: 10.1161/jaha.114.000898.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedChi-Square DistributionChronic DiseaseConnecticutCoronary CirculationCoronary DiseaseDepressionFemaleHemodynamicsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial Perfusion ImagingOdds RatioPredictive Value of TestsPsychiatric Status Rating ScalesRecurrenceRisk FactorsSeverity of Illness IndexStress, PsychologicalTomography, Emission-Computed, Single-PhotonConceptsAcute psychological stressMyocardial perfusionPsychological stressDepressed rangeNormal rangeAcute coronary syndrome (ACS) recurrenceSelective serotonin reuptake inhibitor medicationsStable coronary heart diseaseCoronary heart disease patientsSerotonin reuptake inhibitor medicationsImpaired myocardial perfusionTomography myocardial perfusionCoronary heart diseaseMortality risk factorsOptimal medical careHigh normal rangeReuptake inhibitor medicationsHeart disease patientsBeck Depression InventorySingle photon emissionACS recurrenceCHD prognosisInhibitor medicationVascular mechanismsMeasures of depression
2011
Autonomic Contribution to Endothelin-1 Increase during Laboratory Anger-Recall Stress in Patients with Coronary Artery Disease
Burg MM, Soufer A, Lampert R, Collins D, Soufer R. Autonomic Contribution to Endothelin-1 Increase during Laboratory Anger-Recall Stress in Patients with Coronary Artery Disease. Molecular Medicine 2011, 17: 495-501. PMID: 21267513, PMCID: PMC3105151, DOI: 10.2119/molmed.2010.00083.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseEndothelin-1Parasympathetic activityArtery diseaseAutonomic contributionsChronic stable coronary artery diseaseStable coronary artery diseaseCholinergic antiinflammatory pathwayLaboratory stressCoronary plaque ruptureEndothelin-1 increaseSignificant odds ratioEndothelial cell functionCardiac eventsEndothelial dysfunctionIndwelling catheterAutonomic factorsSympathetic activityAntiinflammatory pathwayAutonomic influencesAutonomic toneOdds ratioPlaque ruptureParasympathetic withdrawalHemodynamic monitor
2010
Tendency to Angry Rumination Predicts Stress-Provoked Endothelin-1 Increase in Patients With Coronary Artery Disease
Fernandez AB, Soufer R, Collins D, Soufer A, Ranjbaran H, Burg MM. Tendency to Angry Rumination Predicts Stress-Provoked Endothelin-1 Increase in Patients With Coronary Artery Disease. Psychosomatic Medicine 2010, 72: 348-353. PMID: 20368479, PMCID: PMC2872076, DOI: 10.1097/psy.0b013e3181d71982.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseET-1 increaseET-1Chronic stable coronary heart diseaseStable coronary heart diseaseMultivariate logistic regression modelET-1 elevationAcute coronary syndromeHistory of diabetesRate-pressure productCoronary artery diseaseEndothelin-1 increaseLogistic regression modelsCoronary syndromeArtery diseaseBeta blockersPotential confoundersPressure productHeart diseasePlaque ruptureBlood samplesPatientsAngry ruminationNitric oxideStress protocolChapter 32 Mechanistic and Methodological Considerations for the Imaging of Mental Stress Ischemia
Soufer R, Burg M, Fernandez A. Chapter 32 Mechanistic and Methodological Considerations for the Imaging of Mental Stress Ischemia. 2010, 491-505. DOI: 10.1016/b978-0-323-05796-7.00058-8.Peer-Reviewed Original Research
2007
Mental stress–induced myocardial ischemia: Moving forward
Burg MM, Soufer R. Mental stress–induced myocardial ischemia: Moving forward. Journal Of Nuclear Cardiology 2007, 14: 269-271. PMID: 17556157, DOI: 10.1016/j.nuclcard.2007.04.009.Peer-Reviewed Original Research
2006
The Implications of Mental Stress for Cardiovascular Disease
Graeber B, Soufer A, Burg M, Soufer R. The Implications of Mental Stress for Cardiovascular Disease. Contemporary Cardiology 2006, 197-215. DOI: 10.1007/978-1-59745-096-6_11.Peer-Reviewed Original Research
2004
Differential impact of parasympathetic withdrawal to mental stress ischemia as assessed by noninvasive evaluation of myocardial perfusion and/or function
Vashist A, Arrighi J, Lampert R, Burg M, Soufer R. Differential impact of parasympathetic withdrawal to mental stress ischemia as assessed by noninvasive evaluation of myocardial perfusion and/or function. Journal Of Nuclear Cardiology 2004, 11: s21. DOI: 10.1016/j.nuclcard.2004.06.068.Peer-Reviewed Original ResearchChronic coronary artery diseaseRegional LV dysfunctionMyocardial ischemiaParasympathetic withdrawalLV dysfunctionChronic chronic coronary artery diseaseMental stress ischemiaRate-pressure productCoronary artery diseaseGreater parasympathetic withdrawalHigh-frequency powerStress ischemiaArtery diseaseNon-invasive imagingMPI defectsSympathovagal balanceIndividual patientsSPECT-MPIIschemiaMyocardial perfusionNoninvasive evaluationPatientsMental arithmetic taskAutonomic responsesSPECT defects1148-208 Psychological stress increases heterogeneity of repolarization in patients with structural heart disease and ventricular arrhythmias
Lampert R, Shusterman V, Burg M, Lee F, Earley C, Goldberg A, McPherson C, Batsford W, Soufer R. 1148-208 Psychological stress increases heterogeneity of repolarization in patients with structural heart disease and ventricular arrhythmias. Journal Of The American College Of Cardiology 2004, 43: a140-a141. DOI: 10.1016/s0735-1097(04)90595-5.Peer-Reviewed Original Research
2001
7.44 Simultaneous assessment of myocardial perfusion and function during mental stress in patients with chronic coronary artery disease
Arrighi J, Burg M, Cohen I, Soufer R. 7.44 Simultaneous assessment of myocardial perfusion and function during mental stress in patients with chronic coronary artery disease. Journal Of Nuclear Cardiology 2001, 8: s51. DOI: 10.1016/s1071-3581(01)80621-8.Peer-Reviewed Original Research
2000
Myocardial blood-flow response during mental stress in patients with coronary artery disease
Arrighi J, Burg M, Cohen I, Kao A, Pfau S, Caulin-Glaser T, Zaret B, Soufer R. Myocardial blood-flow response during mental stress in patients with coronary artery disease. The Lancet 2000, 356: 310-311. PMID: 11071190, DOI: 10.1016/s0140-6736(00)02510-1.Peer-Reviewed Original Research
1999
Myocardial blood flow decreases during mental stress independent of vasodilator capacity/severity of CAD
Arrighi J, Burg M, Cohen I, Bremner D, Zaret B, Soufer R. Myocardial blood flow decreases during mental stress independent of vasodilator capacity/severity of CAD. Journal Of Nuclear Cardiology 1999, 6: s12. DOI: 10.1016/s1071-3581(99)90162-9.Peer-Reviewed Original ResearchRelationship between mental stress induced LV dysfunction and autonomic nervous system activation
Jain D, Joska T, Lee F, Lampert R, Burg M, Soufer R, Zaret B. Relationship between mental stress induced LV dysfunction and autonomic nervous system activation. Journal Of Nuclear Cardiology 1999, 6: s98. DOI: 10.1016/s1071-3581(99)90503-2.Peer-Reviewed Original Research
1998
Cerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease
Soufer R, Bremner J, Arrighi J, Cohen I, Zaret B, Burg M, Goldman-Rakic P. Cerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 6454-6459. PMID: 9600987, PMCID: PMC27794, DOI: 10.1073/pnas.95.11.6454.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseVisual association cortexSuperior frontal gyrusRight visual association cortexCAD patientsHealthy subjectsPositron emission tomographyMental stressAssociation cortexFrontal gyrusArtery diseaseMyocardial ischemiaAnterior cingulateCentral nervous system effectsCAD patient groupCerebral cortical responsePainless myocardial ischemiaNervous system effectsLeft parietal cortexInferior parietal lobuleMiddle temporal gyrusPatient groupSerial subtraction taskRight thalamusInferior frontal gyrusEffects of Mental Stress on Left Ventricular and Peripheral Vascular Performance in Patients With Coronary Artery Disease
Jain D, Shaker M, Burg M, Wackers F, Soufer R, Zaret B. Effects of Mental Stress on Left Ventricular and Peripheral Vascular Performance in Patients With Coronary Artery Disease. Journal Of The American College Of Cardiology 1998, 31: 1314-1322. PMID: 9581726, DOI: 10.1016/s0735-1097(98)00092-8.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionPeripheral vascular resistanceCoronary artery diseaseRate-pressure productStress-induced fallSystolic blood pressureArtery diseaseBlood pressureCardiac outputHeart rateMental stressGroup IHemodynamic variablesAnger recallGroup IIMental stressorsEnd-systolic ventricular elastanceMental stress-induced changesSemisupine bicycle exerciseGroup II patientsComparable increaseDiastolic blood pressureVentricular ejection fractionExercise-induced changesVascular resistance
1997
Relationship of regional myocardial blood flow to mental stress and ischemia by exercise thallium
Arrighi J, Kao A, Burg M, Soufer R. Relationship of regional myocardial blood flow to mental stress and ischemia by exercise thallium. Journal Of Nuclear Cardiology 1997, 4: s85. DOI: 10.1016/s1071-3581(97)91451-3.Peer-Reviewed Original Research
1996
Day to day reproducibility of mental stress induced left ventricular dysfunction
Jain D, Burg M, Soufer R, Cozza T, Zaret B. Day to day reproducibility of mental stress induced left ventricular dysfunction. Journal Of The American College Of Cardiology 1996, 27: 240. DOI: 10.1016/s0735-1097(96)81835-3.Peer-Reviewed Original Research
1995
Prognostic Implications of Mental Stress-Induced Silent Loft Ventricular Dysfunction in Patients With Stable Angina Pectoris
Jain D, Burg M, Soufer R, Zaret B. Prognostic Implications of Mental Stress-Induced Silent Loft Ventricular Dysfunction in Patients With Stable Angina Pectoris. The American Journal Of Cardiology 1995, 76: 31-35. PMID: 7793399, DOI: 10.1016/s0002-9149(99)80796-6.Peer-Reviewed Original ResearchConceptsStable angina pectorisTransient LV dysfunctionAdverse cardiac eventsCardiac eventsLV dysfunctionAngina pectorisMental stressAbnormal cardiovascular reactivityHigher cardiac eventsCohort of patientsCoronary artery diseaseGroup of patientsVentricular function monitoringMental arithmeticVentricular dysfunctionAdverse eventsBaseline characteristicsBeta blockersContinuous ambulatoryArtery diseaseRisk stratificationPrognostic implicationsStress perfusionFunction monitoringHeart rateEjection fraction fall during mental stress in coronary artery disease: Is it due to peripheral effects or contractile dysfunction?
Shaker S, Jain D, Burg M, Wackers F, Soufer R, Zaret B. Ejection fraction fall during mental stress in coronary artery disease: Is it due to peripheral effects or contractile dysfunction? Journal Of Nuclear Cardiology 1995, 2: s27. DOI: 10.1016/s1071-3581(05)80195-3.Peer-Reviewed Original ResearchPrognostic value of mental stress induced silent left ventricular dysfunction in coronary artery disease
Jain D, Burg M, Soufer R, Zaret B. Prognostic value of mental stress induced silent left ventricular dysfunction in coronary artery disease. Journal Of Nuclear Cardiology 1995, 2: s91. DOI: 10.1016/s1071-3581(05)80449-0.Peer-Reviewed Original Research