Lingzhong Meng, MD

Professor of Anesthesiology; Chief, Division of Neuro Anesthesia

Departments & Organizations

Anesthesiology

Faculty Research

Yale Medicine

Biography

Dr. Meng is boarded in Anesthesiology. He is a Professor in the Department of Anesthesiology at Yale University where he heads the Neuro Anesthesia Division. He obtained MD degree from Peking Union Medical College in Beijing, China. His clinical work involves primarily anesthetic care for patients undergoing various neurological surgeries/procedures. His current research focuses on outcome improvement via optimized physiological management in the perioperative setting.

Education & Training

MD Peking Union Medical College (1997)
Internship Vanderbilt University
Residency University of Miami
Residency University of California Los Angeles
Board Certification AB of Anesthesiology, Anesthesiology (2009)

Honors & Recognition

  • Guest ProfessorWeifang People's Hospital, Weifang, Shandong Province, China (2016)

  • Guest ProfessorXiangya Hospital, Central South University, Changsha, Hunan Province, China (2016)

  • Guest ProfessorXuanwu Hospital, Capital Medical University, Beijing, China (2016)

  • Guest ProfessorXi’an Jiaotong University School of Medicine, Xi’an, Shaanxi Province, China (2016)

  • Guest ProfessorWeifang Medical College, Weifang, Shandong Province, China (2015)

  • Awards for Seed Funding for Clinically Oriented ResearchDepartment of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California (2015)

  • Academic Senate Travel Grant AwardUniversity of California San Francisco Academic Senate, San Francisco, California (2014)

  • Outstanding Contribution AwardInternational Chinese Academy of Anesthesiology (ICAA) (2013)

Professional Service

  • International Chinese Academy of Anesthesiology (ICAA) (2016 - Present) Member, Executive Board

Activities

  • Yale New Haven Hospital New Haven, United States (2016)

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Contact Info

Lingzhong Meng, MD
Mailing Address
Yale Department of Anesthesiology
333 Cedar Street, TMP 3

New Haven, CT 06520
Effect of phenylephrine and ephedrine bolus treatment on blood pressure, cardiac output, and cerebral oxygenation

Following phenylephrine administration, even though blood pressure is increased, both cardiac output and cerebral oxygenation are decreased. In contrast, both cardiac output and cerebral oxygenation are maintained after ephedrine administration which also leads to an increase of blood pressure. It implies that different vasoactive drugs exert different impacts on systemic circulation and organ perfusion/oxygenation. The mechanisms behind these observations have been explored and the clinical significance awaits to be determined. Meng L, Cannesson M, Alexander BS, Yu Z, Kain ZN, Cerussi AE, Tromberg BJ, Mantulin WW. Effect of phenylephrine and ephedrine bolus treatment on cerebral oxygenation in anaesthetized patients. Br J Anaesth. 2011;107:209-17.

Integrated multifactorial CBF regulation

"The proposed conceptualization integrating various CBF-regulating mechanisms within the framework of cerebral autoregulation has important clinical implications. The habitual thinking that how the brain is perfused is merely dependent on the blood pressure should be abandoned. The autoregulatory curve should be regarded as a dynamic process, meaning that its shape, plateau, and the lower and upper limits may change depending on the integrated effect of nonpressure but CBF-regulating mechanisms including the CO. For a given value of blood pressure, even though it is deemed clinically acceptable, the CBF may be either higher or lower than that estimated by the traditional autoregulatory curve. Therefore, the management of CBF should be guided by a multifactorial but integrated framework of CBF regulation, especially in patients who are at risk of cerebral ischemia." Meng L, Hou W, Chui J, Han R, Gelb AW. Cardiac Output and Cerebral Blood Flow: The Integrated Regulation of Brain Perfusion in Adult Humans. Anesthesiology. 2015;123:1198-208.