Featured Publications
Angiophagy
Grutzendler J. Angiophagy. Stroke 2013, 44: s84-s86. PMID: 23709741, DOI: 10.1161/strokeaha.112.678730.Peer-Reviewed Original ResearchRegional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes
Hill RA, Tong L, Yuan P, Murikinati S, Gupta S, Grutzendler J. Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes. Neuron 2015, 87: 95-110. PMID: 26119027, PMCID: PMC4487786, DOI: 10.1016/j.neuron.2015.06.001.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsCerebral blood flowBlood flowCapillary pericytesArteriolar smooth muscle cellsBlood flow regulationRegional blood flowNormal brain functionSmooth muscle actinSmooth muscle cell contractilityMuscle cell contractilityPericyte constrictionIschemic brainBrain ischemiaMicrovascular occlusionNeurovascular couplingMicrovascular diametersWhisker stimulationMuscle actinMuscle cellsBrain functionMajor causePathological conditionsPericytesVascular tree
2019
Cellular Control of Brain Capillary Blood Flow: In Vivo Imaging Veritas
Grutzendler J, Nedergaard M. Cellular Control of Brain Capillary Blood Flow: In Vivo Imaging Veritas. Trends In Neurosciences 2019, 42: 528-536. PMID: 31255380, PMCID: PMC7386067, DOI: 10.1016/j.tins.2019.05.009.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCapillariesCerebrovascular CirculationHemodynamicsHumansNeurovascular CouplingConceptsCapillary blood flowBlood flowBrain capillary blood flowRegional cerebral blood flowCerebral blood flowRed blood cell deformabilityBlood cell deformabilityMicrovascular perfusionNeurovascular couplingMicrovascular flowBrain metabolitesMural cellsLevel-dependent changesNeural activationVessel diameterMicrovascular treeNeural activityCell deformabilityCell controlDirect visualizationMethodological standardsVasomotilityPerfusionControl
2016
“Small Blood Vessels: Big Health Problems?”: Scientific Recommendations of the National Institutes of Health Workshop
Bosetti F, Galis Z, Bynoe M, Charette M, Cipolla M, del Zoppo G, Gould D, Hatsukami T, Jones T, Koenig J, Lutty G, Maric‐Bilkan C, Stevens T, Tolunay H, Koroshetz W, Participants T, Agalliu D, Antonetti D, Boehm M, Brooks C, Caron K, Chilian W, Daemen M, D'Amato R, Davis T, Ergul A, Faber J, Gomez A, Grayson P, Grumbach I, Grutzendler J, Gu C, Gutterman D, Hallenbeck J, Herman I, Humphrey J, Iadecola C, Inscho E, Kleinfeld D, Lo E, Lopez J, Macknik S, Malik A, Mayadas T, McGavern D, Meininger G, Miller V, Nedergaard M, Nelson M, Peirce‐Cottler S, Ramadan I, Rosenberg G, Schiffrin E, Searson P, Stachenfeld N, Stan R, Suarez Y, Ubogu E, Vexler Z, Weyand C, Zlokovic B. “Small Blood Vessels: Big Health Problems?”: Scientific Recommendations of the National Institutes of Health Workshop. Journal Of The American Heart Association 2016, 5: e004389. PMID: 27815267, PMCID: PMC5210346, DOI: 10.1161/jaha.116.004389.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2013
Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period
Whiteus C, Freitas C, Grutzendler J. Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period. Nature 2013, 505: 407-411. PMID: 24305053, PMCID: PMC3947100, DOI: 10.1038/nature12821.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBlood VesselsCapillariesCell ProliferationCerebral CortexCerebrovascular CirculationDendritic SpinesEndothelial CellsFemaleHypoxia, BrainInterneuronsMaleMiceMicrocirculationNeovascularization, PathologicNeovascularization, PhysiologicNeurogliaNeuronsNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthaseOxygenSignal TransductionTime FactorsVibrissae