Featured Publications
Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy
Schain AJ, Hill RA, Grutzendler J. Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy. Nature Medicine 2014, 20: 443-449. PMID: 24681598, PMCID: PMC3981936, DOI: 10.1038/nm.3495.Peer-Reviewed Original Research
2018
Flexible Learning-Free Segmentation and Reconstruction of Neural Volumes
Shahbazi A, Kinnison J, Vescovi R, Du M, Hill R, Joesch M, Takeno M, Zeng H, da Costa NM, Grutzendler J, Kasthuri N, Scheirer WJ. Flexible Learning-Free Segmentation and Reconstruction of Neural Volumes. Scientific Reports 2018, 8: 14247. PMID: 30250218, PMCID: PMC6155135, DOI: 10.1038/s41598-018-32628-3.Peer-Reviewed Original ResearchConceptsGigabytes of dataSupervised learning methodsHigh-energy synchrotron X-ray microtomographyHigh-quality reconstructionComputer visionHigh biological fidelityVirtual eyeSpectral confocal reflectance microscopyStack of imagesLearning methodsPipeline reconstructionContextual cluesDifferent modalitiesNeural volumeMouse datasetsBiological fidelityImagesData collectionPipelineGigabytesSegmentationMachineAlgorithmDatasetSufficient quality