2021
Intravital Imaging of Neocortical Heterotopia Reveals Aberrant Axonal Pathfinding and Myelination around Ectopic Neurons
Li AM, Hill RA, Grutzendler J. Intravital Imaging of Neocortical Heterotopia Reveals Aberrant Axonal Pathfinding and Myelination around Ectopic Neurons. Cerebral Cortex 2021, 31: 4340-4356. PMID: 33877363, PMCID: PMC8328209, DOI: 10.1093/cercor/bhab090.Peer-Reviewed Original ResearchConceptsNeuronal clustersEarly postnatal developmentVivo calcium imagingEctopic neuronal clustersAxonal patternNeocortical heterotopiaHeterotopic neuronsCortical heterotopiaHeterotopia formationEctopic neuronsAnimal modelsTractable animal modelPostnatal developmentCalcium imagingBrain regionsInducible modelIntravital imagingNeuronsAxonal pathfindingAberrant patternsHeterotopiaMyelinationAxon guidanceCognitive disabilitiesLive mice
2006
Two-photon imaging of synaptic plasticity and pathology in the living mouse brain
Grutzendler J, Gan WB. Two-photon imaging of synaptic plasticity and pathology in the living mouse brain. Neurotherapeutics 2006, 3: 489-496. PMID: 17012063, PMCID: PMC3593400, DOI: 10.1016/j.nurx.2006.07.005.Peer-Reviewed Original ResearchConceptsTwo-photon microscopyMouse brainAcute brain injuryPostsynaptic dendritic spinesAdult mouse brainCerebral ischemiaSynaptic pathologyCerebrovascular diseaseBrain injuryMouse modelDendritic spinesAnimal modelsBrain cellsIntact brainTwo-photon imagingNeuronal connectionsSynaptic plasticityAlzheimer's diseaseNeuronal structuresDiseaseBrainStructural plasticityPathologyTechnical considerationsIschemia