1996
Cytotoxic γδ T Lymphocytes Associated with an Epstein–Barr Virus-Induced Posttransplantation Lymphoproliferative Disorder
Rothenberg M, Weber W, Longtine J, Hafler D. Cytotoxic γδ T Lymphocytes Associated with an Epstein–Barr Virus-Induced Posttransplantation Lymphoproliferative Disorder. Clinical Immunology 1996, 80: 266-272. PMID: 8811046, DOI: 10.1006/clin.1996.0122.Peer-Reviewed Original ResearchConceptsGamma delta T cellsDelta T cellsGamma delta T-cell receptorDelta T-cell receptorPosttransplantation lymphoproliferative diseaseT cellsBrain lesionsT cell receptorLymphoproliferative diseaseCell receptorInflammatory brain lesionsPosttransplantation lymphoproliferative disorderEpstein-Barr virusCultured T cell linesCentral nervous systemT cell linesHuman brain tissueLymphoproliferative disordersAutoimmune diseasesInflammatory processVirus immunityNervous systemBrain tissueLesionsTarget cells
1995
Increased frequency of gamma delta T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis. Reactivity, cytotoxicity, and T cell receptor V gene rearrangements.
Stinissen P, Vandevyver C, Medaer R, Vandegaer L, Nies J, Tuyls L, Hafler DA, Raus J, Zhang J. Increased frequency of gamma delta T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis. Reactivity, cytotoxicity, and T cell receptor V gene rearrangements. The Journal Of Immunology 1995, 154: 4883-94. PMID: 7722338, DOI: 10.4049/jimmunol.154.9.4883.Peer-Reviewed Original ResearchConceptsGamma delta T cell clonesGamma delta T cellsDelta T cellsT cell clonesGamma delta clonesMultiple sclerosisPeripheral bloodT cellsCerebrospinal fluidMS patientsOND patientsCell clonesControl subjectsNormal individualsBacterial superantigen staphylococcal enterotoxin BCentral nervous system demyelinationCSF of patientsSuperantigen staphylococcal enterotoxin BToxic shock syndrome toxin-1Nervous system demyelinationClonal originSecondary inflammatory processesV gene usageSyndrome toxin-1Staphylococcal enterotoxin B
1992
Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions.
Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML, Hafler DA. Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 4588-4592. PMID: 1374907, PMCID: PMC49128, DOI: 10.1073/pnas.89.10.4588.Peer-Reviewed Original ResearchConceptsGamma delta T cellsDelta T cellsT cellsMultiple sclerosisMS plaquesCentral nervous system inflammatory processesAcute multiple sclerosis lesionsT cell receptor repertoireGamma delta T-cell receptor repertoireHeat shock proteinsAcute MS plaquesMS plaque tissueNormal CNS tissueDistinct lymphocyte populationsT cell populationsMultiple sclerosis lesionsShock proteinsAcute plaquesReactive astrocytesLymphocyte populationsInflammatory processFoamy macrophagesCNS tissueInflammatory sitesQuantitative immunohistochemistry