2012
A Neuron-Specific Role for Autophagy in Antiviral Defense against Herpes Simplex Virus
Yordy B, Iijima N, Huttner A, Leib D, Iwasaki A. A Neuron-Specific Role for Autophagy in Antiviral Defense against Herpes Simplex Virus. Cell Host & Microbe 2012, 12: 334-345. PMID: 22980330, PMCID: PMC3454454, DOI: 10.1016/j.chom.2012.07.013.Peer-Reviewed Original ResearchConceptsI interferonHSV-1 replicationDorsal root ganglionic neuronsType I IFN treatmentHerpes simplex type 1I IFN treatmentI IFNsHSV-1 infectionHerpes simplex virusNeuron-specific rolesSimplex type 1Type I interferonMucosal epithelial cellsDRG neuronsGanglionic neuronsNeurotropic virusesIFN treatmentSimplex virusViral infectionAntiviral pathwaysViral replicationType 1Antiviral strategiesLittle type INeurons
2010
Clinicopathologic study of glioblastoma in children with neurofibromatosis type 1
Huttner AJ, Kieran MW, Yao X, Cruz L, Ladner J, Quayle K, Goumnerova LC, Irons MB, Ullrich NJ. Clinicopathologic study of glioblastoma in children with neurofibromatosis type 1. Pediatric Blood & Cancer 2010, 54: 890-896. PMID: 20310005, DOI: 10.1002/pbc.22462.Peer-Reviewed Original ResearchMeSH KeywordsBrain NeoplasmsChildChild, PreschoolDNA Modification MethylasesDNA Repair EnzymesErbB ReceptorsGene DosageGlioblastomaHumansImmunohistochemistryIn Situ HybridizationInfantKaplan-Meier EstimateMaleNeurofibromatosis 1PTEN PhosphohydrolaseRetrospective StudiesTumor Suppressor Protein p53Tumor Suppressor ProteinsConceptsNeurofibromatosis type 1Malignant tumorsType 1Median overall survivalLow-grade tumorsPeripheral nervous systemEpidermal growth factor receptor copy numberNon-NF1 patientsAdditional molecular studiesClinicopathologic studyOverall prognosisOverall survivalRetrospective reviewVascular proliferationPathologic indicatorsPatientsNervous systemTumors differsSame time periodGlioblastomaSmall sample sizeTumorsMethylguanine-DNA methyltransferase (MGMT) geneSurvivalChildren