2015
Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis
Erson-Omay EZ, Çağlayan AO, Schultz N, Weinhold N, Omay SB, Özduman K, Köksal Y, Li J, Serin Harmancı A, Clark V, Carrión-Grant G, Baranoski J, Çağlar C, Barak T, Coşkun S, Baran B, Köse D, Sun J, Bakırcıoğlu M, Moliterno Günel J, Pamir MN, Mishra-Gorur K, Bilguvar K, Yasuno K, Vortmeyer A, Huttner AJ, Sander C, Günel M. Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis. Neuro-Oncology 2015, 17: 1356-1364. PMID: 25740784, PMCID: PMC4578578, DOI: 10.1093/neuonc/nov027.Peer-Reviewed Original ResearchConceptsHigh-grade gliomasSomatic POLE mutationsPOLE mutationsMalignant high-grade gliomasLonger progression-free survivalProgression-free survivalSomatic mutationsOverall survivalPediatric patientsBetter prognosisClinical featuresImproved prognosisClinical behaviorImmune cellsBizarre cellsAggressive formGlioblastoma multiformeDisease pathophysiologyMolecular subgroupsHomozygous germline mutationGermline mutationsPrognosisGlioma subtypesComprehensive genomic analysisDistinct subgroups
2012
Overview of Primary Brain Tumors Pathologic Classification, Epidemiology, Molecular Biology, and Prognostic Markers
Huttner A. Overview of Primary Brain Tumors Pathologic Classification, Epidemiology, Molecular Biology, and Prognostic Markers. Hematology/Oncology Clinics Of North America 2012, 26: 715-732. PMID: 22794280, DOI: 10.1016/j.hoc.2012.05.004.Peer-Reviewed Original ResearchConceptsBrain tumor patientsBrain tumor tissueMolecular diagnostic testingMolecular diagnostic testsMultidisciplinary managementPrimary brainNeuroepithelial tumorsHistopathological assessmentPathologic classificationPrognostic markerTumor patientsClinical significanceBrain tumorsClinical practiceTumor tissueDiagnostic testingDiagnostic testsMolecular testsTumorsTumor classificationEpigenetic changesPatientsOverview of classificationPrognosisNeuropathology