2025
Artificial Intelligence–Guided Lung Ultrasound by Nonexperts
Baloescu C, Bailitz J, Cheema B, Agarwala R, Jankowski M, Eke O, Liu R, Nomura J, Stolz L, Gargani L, Alkan E, Wellman T, Parajuli N, Marra A, Thomas Y, Patel D, Schraft E, O’Brien J, Moore C, Gottlieb M. Artificial Intelligence–Guided Lung Ultrasound by Nonexperts. JAMA Cardiology 2025, 10: 245-253. PMID: 39813064, PMCID: PMC11904735, DOI: 10.1001/jamacardio.2024.4991.Peer-Reviewed Original ResearchThis study shows AI helps non-experts create expert-quality lung ultrasound images, which may improve healthcare diagnostics access in underserved areas.
2024
Qualitative interview study of patient-reported symptoms, impacts and treatment goals of patients with obstructive hypertrophic cardiomyopathy
Shore S, Ervin C, Kosa K, Fehnel S, Salberg L, Butzner M, Heitner S, Jacoby D, Saberi S. Qualitative interview study of patient-reported symptoms, impacts and treatment goals of patients with obstructive hypertrophic cardiomyopathy. BMJ Open 2024, 14: e081323. PMID: 39289016, PMCID: PMC11409399, DOI: 10.1136/bmjopen-2023-081323.Peer-Reviewed Original ResearchConceptsQualitative interview studyTreatment goalsShortness of breathTreatment goals of patientsInterview studyAffecting health statusGoals of patientsHypertrophic Cardiomyopathy AssociationPatient-reported symptomsSemi-structured interviewsPhysical functionPatient experiencePatient perspectiveSymptom burdenUS adultsObstructive HCMObstructive hypertrophic cardiomyopathyHealth statusTelephone interviewsPsychosocial impactChest pain/pressureLifestyle-limiting symptomsHypertrophic cardiomyopathyImproving shortness of breathDizziness/light-headednessMan With Dyspnea
Boivin Z, Cannata D, She T. Man With Dyspnea. Annals Of Emergency Medicine 2024, 83: 166-167. PMID: 38245230, DOI: 10.1016/j.annemergmed.2023.08.480.Peer-Reviewed Original Research"In their own words": delineating the contours of dyspnea invisibility in patients with advanced chronic obstructive pulmonary disease from quantitative discourse analysis
Dedonder J, Gelgon C, Guerder A, Nion N, Lavault S, Morélot-Panzini C, Gonzalez-Bermejo J, Benoit L, Similowski T, Serresse L. "In their own words": delineating the contours of dyspnea invisibility in patients with advanced chronic obstructive pulmonary disease from quantitative discourse analysis. Respiratory Research 2024, 25: 21. PMID: 38178139, PMCID: PMC10768212, DOI: 10.1186/s12931-023-02655-4.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseasePulmonary diseaseAdvanced chronic obstructive pulmonary diseaseChronic respiratory disease patientsRespiratory disease patientsPersistent dyspneaCOPD patientsDisease patientsMaximal treatmentPatient concernsCausative abnormalityInterpretative phenomenological analysisPatientsDaily limitationsDiseaseBasic activitiesDistressing experiencePatients' discourseNovel informationBackgroundDyspneaDyspneaExacerbationHospitalAbnormalities
2023
Efficacy and safety of luspatercept versus epoetin alfa in erythropoiesis-stimulating agent-naive, transfusion-dependent, lower-risk myelodysplastic syndromes (COMMANDS): interim analysis of a phase 3, open-label, randomised controlled trial
Platzbecker U, Della Porta M, Santini V, Zeidan A, Komrokji R, Shortt J, Valcarcel D, Jonasova A, Dimicoli-Salazar S, Tiong I, Lin C, Li J, Zhang J, Giuseppi A, Kreitz S, Pozharskaya V, Keeperman K, Rose S, Shetty J, Hayati S, Vodala S, Prebet T, Degulys A, Paolini S, Cluzeau T, Fenaux P, Garcia-Manero G. Efficacy and safety of luspatercept versus epoetin alfa in erythropoiesis-stimulating agent-naive, transfusion-dependent, lower-risk myelodysplastic syndromes (COMMANDS): interim analysis of a phase 3, open-label, randomised controlled trial. The Lancet 2023, 402: 373-385. PMID: 37311468, DOI: 10.1016/s0140-6736(23)00874-7.Peer-Reviewed Original ResearchConceptsLower-risk myelodysplastic syndromesRed blood cell transfusion independenceEpoetin alfa groupErythropoiesis-stimulating agentsEpoetin alfaMyelodysplastic syndromeInterim analysisPrimary endpointAdverse eventsAlfa groupTransfusion independenceLower riskBody weightTreatment-emergent adverse eventsTreatment-related adverse eventsRed blood cell transfusionDurable clinical efficacyMean hemoglobin increaseMedian treatment exposureBlood cell transfusionCOVID-19 pneumoniaSubgroup of patientsWeeks of treatmentTreatment of anemiaAcute myeloid leukemiaA 46-Year-Old Woman With Chronic Dyspnea and Diarrhea
Kshattry S, White M, Tchack J, Laskin W, Kunz P. A 46-Year-Old Woman With Chronic Dyspnea and Diarrhea. CHEST Journal 2023, 163: e23-e29. PMID: 36628681, DOI: 10.1016/j.chest.2022.08.2214.Peer-Reviewed Original ResearchMeSH KeywordsChildCoughDiagnosis, DifferentialDiarrheaDyspneaFemaleHemoptysisHumansMiddle AgedThoraxConceptsPack-year historyCurrent tobacco usePertinent medical historyReview of systemsNew edemaAbdominal painChest painChronic dyspneaHealthy womenHot flashesRecent travelMedical historyDegree relativesFamily historyTobacco useOlder womenColon cancerHeart palpitationsMedical careWeight lossDyspneaPainDiarrheaWomenEpisodes
2022
The long-term effect of dupilumab on dyspnea, sleep, and activity in oral corticosteroid-dependent severe asthma
Sher L, Passalacqua G, Taillé C, Cohn L, Daizadeh N, Pandit-Abid N, Soler X, Khodzhayev A, Jacob-Nara J, Deniz Y, Rowe P, Nag A, Zhang Y. The long-term effect of dupilumab on dyspnea, sleep, and activity in oral corticosteroid-dependent severe asthma. Annals Of Allergy Asthma & Immunology 2022, 130: 298-304. PMID: 36509407, DOI: 10.1016/j.anai.2022.12.002.Peer-Reviewed Original ResearchConceptsPlacebo-treated patientsSevere asthmaActivity limitationsDose reductionAQLQ scoresDupilumab groupWeek 24Open-label extensionProportion of patientsType 2 inflammationHuman monoclonal antibodyQuality of lifeOral corticosteroidsOCS useInterleukin-4Long-term effectsAsthmaPatientsSymptomsMonoclonal antibodiesSleepReceptor componentsDupilumabDyspneaWeeks‘You can’t feel what we feel’: Multifaceted dyspnoea invisibility in advanced chronic obstructive pulmonary disease examined through interpretative phenomenological analysis
Serresse L, Guerder A, Dedonder J, Nion N, Lavault S, Morélot-Panzini C, Gonzalez-Bermejo J, Benoit L, Similowski T. ‘You can’t feel what we feel’: Multifaceted dyspnoea invisibility in advanced chronic obstructive pulmonary disease examined through interpretative phenomenological analysis. Palliative Medicine 2022, 36: 1364-1373. PMID: 36154535, DOI: 10.1177/02692163221118198.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseAdvanced chronic obstructive pulmonary diseasePulmonary diseaseSevere chronic obstructive pulmonary diseaseTertiary care university hospitalCare university hospitalPathophysiological treatmentUniversity HospitalRehabilitation facilityAppropriate careInterpretative phenomenological analysisHealthcare professionalsDiseaseSymptomsObjective measurementsFamily membersBurdenDepth semi-structured interviewsSemi-structured interviewsDyspnoeaHospitalPhenomenological analysisA 43-Year-Old Woman With Fatigue, Pancytopenia, and Mediastinal Adenopathy
Zeba F, Marotti J, Feller-Kopman D. A 43-Year-Old Woman With Fatigue, Pancytopenia, and Mediastinal Adenopathy. CHEST Journal 2022, 161: e293-e297. PMID: 35526899, DOI: 10.1016/j.chest.2021.12.653.Peer-Reviewed Original ResearchConceptsFamily history of malignancyHistory of malignancyHeavy menstrual bleedingAdmitted with fatigueSignificant medical historyShortness of breathFamily historySmoking habitsJoint painNeck swellingMediastinal adenopathyMenstrual bleedingEnvironmental exposuresNight sweatsMedical historyWeight lossWomenCurrent presentFatigueSmokingAdenopathyPancytopeniaMediastinitisMalignancyMedicationPneumonitis after immune checkpoint inhibitor therapies in patients with acute myeloid leukemia: A retrospective cohort study
Sheshadri A, Goizueta A, Shannon V, London D, Garcia‐Manero G, Kantarjian H, Ravandi‐Kashani F, Kadia T, Konopleva M, DiNardo C, Pierce S, Zarifa A, Albittar A, Zhong L, Akhmedzhanov F, Arain M, Alfayez M, Alotaibi A, Altan M, Naing A, Mendoza T, Godoy M, Shroff G, Kim S, Faiz S, Kontoyiannis D, Khawaja F, Jennings K, Daver N. Pneumonitis after immune checkpoint inhibitor therapies in patients with acute myeloid leukemia: A retrospective cohort study. Cancer 2022, 128: 2736-2745. PMID: 35452134, PMCID: PMC9232977, DOI: 10.1002/cncr.34229.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsAcute myeloid leukemiaImmune checkpoint inhibitor therapyAcute myeloid leukemia patientsICI-related pneumonitisPneumonitis riskMyeloid leukemiaCheckpoint inhibitorsEffect of immune checkpoint inhibitorsFemale sexReduced T-cell functionRisk factorsMultivariate Cox proportional hazards modelICI-containing regimensMultidisciplinary adjudication committeeRate of pneumonitisCheckpoint inhibitor therapyTreating acute myeloid leukemiaIncreased platelet countIncreased mortalityResponse to therapyT cell functionRetrospective cohort studyAttack cancer cellsCox proportional hazards models
2021
Interobserver Agreement and Correlation of an Automated Algorithm for B‐Line Identification and Quantification With Expert Sonologist Review in a Handheld Ultrasound Device
Moore CL, Wang J, Battisti AJ, Chen A, Fincke J, Wang A, Wagner M, Raju B, Baloescu C. Interobserver Agreement and Correlation of an Automated Algorithm for B‐Line Identification and Quantification With Expert Sonologist Review in a Handheld Ultrasound Device. Journal Of Ultrasound In Medicine 2021, 41: 2487-2495. PMID: 34964489, DOI: 10.1002/jum.15935.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsDyspneaHumansObserver VariationReproducibility of ResultsUltrasonographyConceptsIntraclass correlation coefficientHandheld ultrasound deviceB-linesAdult emergency department patientsPathologic lung conditionsEmergency department patientsUltrasound deviceDepartment patientsLung conditionsClinical studiesInterobserver agreementWeighted KappaUltrasound expertsPatientsCountMultiple settingsKappaUnique subjectsDyspneaClearing the Congestion
Berman J, Lee L, Monga R, Ye K, Sprayregen S, Haramati L. Clearing the Congestion. Journal Of Thoracic Imaging 2021, 38: 18-22. PMID: 34739426, DOI: 10.1097/rti.0000000000000625.Peer-Reviewed Original ResearchConceptsNormal brain natriuretic peptideBrain natriuretic peptideCongestive heart failureHistory of CHFSerum brain natriuretic peptideHigher body mass indexBody mass indexBNP levelsMass indexPresence of CHFHigher serum BNP levelsSerum BNP levelsEmergency department patientsED cohortCXR resultsHeart failureDepartment patientsED patientsStudy cohortNatriuretic peptideClinical dilemmaChest radiographsPatientsCXRLogistic regressionCO-Oximetry Interference in a Patient with Dyspnea Refractory to Oxygen Therapy
Binns TC, Koch CD, Durant TJS, El-Khoury JM. CO-Oximetry Interference in a Patient with Dyspnea Refractory to Oxygen Therapy. The Journal Of Applied Laboratory Medicine 2021, 6: 1671-1676. PMID: 34383919, DOI: 10.1093/jalm/jfab071.Peer-Reviewed Case Reports and Technical NotesImmuno-fibrotic drivers of impaired lung function in post-acute sequelae of SARS-CoV-2
Chun HJ, Coutavas E, Pine AB, Lee AI, Yu VL, Shallow MK, Giovacchini CX, Mathews AM, Stephenson B, Que LG, Lee PJ, Kraft BD. Immuno-fibrotic drivers of impaired lung function in post-acute sequelae of SARS-CoV-2. JCI Insight 2021, 6: e148476. PMID: 34111030, PMCID: PMC8410030, DOI: 10.1172/jci.insight.148476.Peer-Reviewed Original ResearchConceptsCOVID-19 severityIntensive care unitCOVID-19 illnessRespiratory symptomsLipocalin-2Acute COVID-19 illnessSARS-CoV-2 infectionCOVID-19Acute COVID-19Mild COVID-19Prospective cohort studyPulmonary function testsPost-acute sequelaeAmerican Heart AssociationHost response profileSeparate validation cohortAcademic medical centerSARS-CoV-2Plasma biomarker profilesICU groupLung recoveryCohort studyExpiratory volumeLung impairmentPersistent symptomsParamedic-performed Prehospital Point-of-care Ultrasound for Patients with Undifferentiated Dyspnea: A Pilot Study
Schoeneck JH, Coughlin RF, Baloescu C, Cone DC, Liu RB, Kalam S, Medoro AK, Medoro I, Joseph D, Burns K, Bohrer-Clancy JI, Moore CL. Paramedic-performed Prehospital Point-of-care Ultrasound for Patients with Undifferentiated Dyspnea: A Pilot Study. Western Journal Of Emergency Medicine 2021, 22: 750-755. PMID: 34125056, PMCID: PMC8203026, DOI: 10.5811/westjem.2020.12.49254.Peer-Reviewed Original ResearchAn 84-Year-Old Physician With Progressive Dyspnea and Bilateral Upper Lobe Opacities
Harris ZM, Antin-Ozerkis D. An 84-Year-Old Physician With Progressive Dyspnea and Bilateral Upper Lobe Opacities. CHEST Journal 2021, 159: e325-e329. PMID: 33965157, DOI: 10.1016/j.chest.2020.12.035.Peer-Reviewed Original ResearchConceptsProgressive exertional dyspneaNumbness/tinglingLong-term medicationProximal muscle weaknessParoxysmal atrial fibrillationLifelong nonsmokersNaproxen 250Progressive dyspneaDry coughExertional dyspneaNight sweatsPulmonary clinicLumbar radiculopathySinus congestionSpinal stenosisAtrial fibrillationMuscle weaknessHashimoto's thyroiditisRecent travelMedical historyOlder physiciansWeight lossDyspneaThyroiditisPhysiciansYoung Man With Shortness of Breath
Hodson DZ, Reinhardt SW, Moore CL. Young Man With Shortness of Breath. Annals Of Emergency Medicine 2021, 77: 500-558. PMID: 33902827, PMCID: PMC8064764, DOI: 10.1016/j.annemergmed.2020.10.026.Peer-Reviewed Case Reports and Technical NotesSpontaneous Biliary Pericardial Tamponade: A Case Report and Literature Review
Battisha A, Altibi A, Madoukh B, Sheikh O, Sawalha K, Shaikh S, Al-Sadawi M. Spontaneous Biliary Pericardial Tamponade: A Case Report and Literature Review. Current Cardiology Reviews 2021, 17: 204-208. PMID: 32525780, PMCID: PMC8226206, DOI: 10.2174/1573403x16666200611132045.Peer-Reviewed Original ResearchConceptsPericardial tamponadeRare formPericardial spacePotential fistulaPericardial fluidPresence of associated malignancyChest wall traumaPericardial injuryCardiac tamponadeHIDA scanAbdominal surgeryDetecting fistulasCase reportTamponadeChest surgeryFistulaIncreased riskBiliary systemHepatobiliary systemWorkupNon-revealingHispanic malesPericardiocentesisSurgeryMale
2020
Progressive Dyspnea and Hypoxemia With Diffuse Pulmonary Infiltrates in a Previously Healthy Woman
Mainardi AS, Siddon AJ, Bader AS, Hilbert J. Progressive Dyspnea and Hypoxemia With Diffuse Pulmonary Infiltrates in a Previously Healthy Woman. CHEST Journal 2020, 158: e327-e334. PMID: 33280778, DOI: 10.1016/j.chest.2020.07.009.Peer-Reviewed Case Reports and Technical NotesConceptsAdmission laboratory test resultsMonths of coughMild respiratory distressViolaceous maculesAcneiform rashProgressive dyspneaAxillary adenopathyNight sweatsHealthy womenNew feverRespiratory distressDiffuse pulmonaryPhysical examinationWBC countPlatelet levelsConjunctival edemaFurther managementOxygen saturationPulmonary cracklesLaboratory test resultsDyspneaRashWomenAdenopathyHypoxemiaCOVID-19 in Great Britain: epidemiological and clinical characteristics of the first few hundred (FF100) cases: a descriptive case series and case control analysis
Boddington N, Charlett A, Elgohari S, Walker J, McDonald H, Byers C, Coughlan L, Vilaplana T, Whillock R, Sinnathamby M, Panagiotopoulos N, Letley L, MacDonald P, Vivancos R, Edeghere O, Shingleton J, Bennett E, Grint D, Strongman H, Mansfield K, Rentsch C, Minassian C, Douglas I, Mathur R, Peppa M, Cottrell S, McMenamin J, Zambon M, Ramsay M, Dabrera G, Saliba V, Bernal J. COVID-19 in Great Britain: epidemiological and clinical characteristics of the first few hundred (FF100) cases: a descriptive case series and case control analysis. Bulletin Of The World Health Organization 2020, 99: 178-189. PMID: 33716340, PMCID: PMC7941108, DOI: 10.2471/blt.20.265603.Peer-Reviewed Original ResearchConceptsProportion of COVID-19 casesPredictive value of symptomsTraining public health professionalsHealth-care seeking behaviorOccurrence of feverCase-control analysisCourse of diseaseSpecificity of symptomsShortness of breathPublic health professionalsProportion of childrenClinical presentationClinical characteristicsExposure to infectionRespiratory infectionsCases of coronavirus disease 2019Household contactsHealth professionalsBurden of COVID-19Predictive valueCase definitionCoronavirus disease 2019COVID-19 casesControl groupFever
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